Details
Stereochemistry | ACHIRAL |
Molecular Formula | C26H23F4N9O |
Molecular Weight | 553.5141 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
FC1=C(C=CN=C1C(F)(F)F)C(=O)N2CCC(CC2)N3CC(CC#N)(C3)N4C=C(C=N4)C5=NC=NC6=C5C=CN6
InChI
InChIKey=KTBSXLIQKWEBRB-UHFFFAOYSA-N
InChI=1S/C26H23F4N9O/c27-20-18(1-7-32-22(20)26(28,29)30)24(40)37-9-3-17(4-10-37)38-13-25(14-38,5-6-31)39-12-16(11-36-39)21-19-2-8-33-23(19)35-15-34-21/h1-2,7-8,11-12,15,17H,3-5,9-10,13-14H2,(H,33,34,35)
Molecular Formula | C26H23F4N9O |
Molecular Weight | 553.5141 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
INCB-039110 (also known as Itacitinib) is an orally bioavailable inhibitor of Janus-associated kinase 1 (JAK1) with potential antineoplastic activity patented by Incyte Corporation for treatment of autoimmune disorders and cancer. Upon oral administration of NCB-039110, this agent selectively inhibits the phosphorylation and activity of JAK1, which may result in inhibition of JAK1-mediated signaling, induction of apoptosis, and reduction of cell proliferation in JAK1-expressing tumor cells. INCB-039110 in combination with nab-paclitaxel plus gemcitabine demonstrated an acceptable safety profile with clinical activity seen in patients with advanced solid tumors including pancreatic cancers. Based on the potential for additive or synergistic effects, NCB-039110 is currently being explored in combination with immunotherapeutic agents including the anti-programmed cell death protein 1 antibody and small molecule inhibitors.
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/30115734
300 mg once daily
Route of Administration:
Oral
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 17 03:37:37 UTC 2022
by
admin
on
Sat Dec 17 03:37:37 UTC 2022
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Record UNII |
19J3781LPM
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Record Status |
Validated (UNII)
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Record Version |
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Code | English |
Classification Tree | Code System | Code | ||
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FDA ORPHAN DRUG |
562716
Created by
admin on Sat Dec 17 03:37:38 UTC 2022 , Edited by admin on Sat Dec 17 03:37:38 UTC 2022
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NCI_THESAURUS |
C1967
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admin on Sat Dec 17 03:37:38 UTC 2022 , Edited by admin on Sat Dec 17 03:37:38 UTC 2022
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NCI_THESAURUS |
C129825
Created by
admin on Sat Dec 17 03:37:38 UTC 2022 , Edited by admin on Sat Dec 17 03:37:38 UTC 2022
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EU-Orphan Drug |
EU/3/17/1964
Created by
admin on Sat Dec 17 03:37:38 UTC 2022 , Edited by admin on Sat Dec 17 03:37:38 UTC 2022
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CD-78
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DB12154
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1334298-90-6
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53380437
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10313
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CHEMBL3544950
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SUB183665
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C116855
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19J3781LPM
Created by
admin on Sat Dec 17 03:37:38 UTC 2022 , Edited by admin on Sat Dec 17 03:37:38 UTC 2022
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PRIMARY |
Related Record | Type | Details | ||
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TARGET -> INHIBITOR | |||
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TARGET -> INHIBITOR | |||
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SALT/SOLVATE -> PARENT |
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ACTIVE MOIETY |