TYROSINE-PROTEIN KINASE JAK3

Approval Year

Substance Class	Protein
Protein Type	KINASE
Protein Sub Type	TYROSINE KINASE
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	9LLR266790
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TYROSINE-PROTEIN KINASE JAK3

Common Name

English

JAK-3

Preferred Name

English

LEUKOCYTE JANUS KINASE

Common Name

English

JANUS KINASE 3

Common Name

English

KINASE (PHOSPHORYLATING), JAK3 PROTEIN (HUMAN GENE JAK3)

Common Name

English

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Code System

Code

Type

Description

WIKIPEDIA

JANUS KINASE 3

PRIMARY

FDA UNII

9LLR266790

PRIMARY

EC (ENZYME CLASS)

EC 2.7.10.2

PRIMARY

CAS

479898-67-4

PRIMARY

CAS

480546-04-1

ALTERNATIVE

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Subunit 0

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Related Record

Type

Details


					H88EPA0A3N

STAUROSPORINE

INHIBITOR -> TARGET


					82S8X8XX8H

Ruxolitinib

INHIBITOR -> TARGET


					2OYE00PC25

RITLECITINIB

INHIBITOR -> TARGET

Qualification:

IC50

Amount:

33.1 NANOMOLAR (average)


					PG8BT6T9MB

WHI-P 154

INHIBITOR -> TARGET

Qualification:

IC50

Amount:

1800 NANOMOLAR (average)


					C4UD8F8XJY

AG-490

WEAK INHIBITOR->TARGET

Qualification:

IC50

Amount:

4300 NANOMOLAR (average)

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Structural Modifications

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Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_17]		SERINE		DEXFOSFOSERINE	VI4F0K069V

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Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER AVERAGE(CALCULATED)	CHEMICAL	NUMBER AVERAGE 125099 DA (average) UNMODIFIED MW
Molecular Formula	CHEMICAL	ESTIMATED C5592H8790N1557O1603PS52

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