TYROSINE-PROTEIN KINASE JAK1

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 12:26:20 GMT 2023` Edited by `admin` on `Sat Dec 16 12:26:20 GMT 2023`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	08S4A2S6FT
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

TYROSINE-PROTEIN KINASE JAK1

Common Name

English

JAK1B

Common Name

English

JANUS KINASE 1

Common Name

English

JAK-1

Common Name

English

JAK1A

Common Name

English

JAK1

Common Name

English

Code System Code Type Description

UNIPROT

P23458

Created by admin on Sat Dec 16 12:26:21 GMT 2023 , Edited by admin on Sat Dec 16 12:26:21 GMT 2023

PRIMARY

FDA UNII

08S4A2S6FT

Created by admin on Sat Dec 16 12:26:21 GMT 2023 , Edited by admin on Sat Dec 16 12:26:21 GMT 2023

PRIMARY

EC (ENZYME CLASS)

EC 2.7.10.2

Created by admin on Sat Dec 16 12:26:21 GMT 2023 , Edited by admin on Sat Dec 16 12:26:21 GMT 2023

PRIMARY

WIKIPEDIA

JANUS KINASE 1

Created by admin on Sat Dec 16 12:26:21 GMT 2023 , Edited by admin on Sat Dec 16 12:26:21 GMT 2023

PRIMARY

Related Record Type Details


					98KDC0ZGX2

N-(CYANOMETHYL)-4-(2-((4-(3-OXO-4-MORPHOLINYL)PHENYL)AMINO)-4-PYRIMIDINYL)BENZAMIDE

INHIBITOR -> TARGET

Qualification:

EC50

Amount:


					PG8BT6T9MB

WHI-P 154

INHIBITOR -> TARGET


					M0ZX82000S

ZM-39923

INHIBITOR -> TARGET


					967GZ3CL34

ABROCITINIB METABOLITE M3

INHIBITOR -> TARGET

Amount:


					86YZ7HCC8V

PF-06263276

INHIBITOR -> TARGET

Qualification:

IC50


					9M632G86CC

TPCA-1

INHIBITOR -> TARGET


					74GK72DON8

JNJ-7706621

INHIBITOR -> TARGET


					3V7GQ1260K

SOLCITINIB

INHIBITOR -> TARGET

Amount:


					C238YE66P2

ATINVICITINIB

INHIBITOR -> TARGET

Amount:


					3BY9Z3M34G

Golidocitinib

INHIBITOR -> TARGET

Amount:


					C0WUS7XXE9

Tuspetinib

INHIBITOR -> TARGET

Amount:


					LFR1253W75

K-00546

INHIBITOR -> TARGET


					6O01GMS00P

MOMELOTINIB

INHIBITOR -> TARGET


					ID912S5VON

MIDOSTAURIN

INHIBITOR -> TARGET


					3X8387Q25N

BREPOCITINIB

INHIBITOR -> TARGET


					YA4DQK8CAT

ABROCITINIB METABOLITE M1

INHIBITOR -> TARGET

Amount:


					3XVL385Q0M

FILGOTINIB

INHIBITOR -> TARGET


					DBA7WU5NH4

TUL-01101

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					7N03P021J8

BMS-911543

INHIBITOR -> TARGET


					H88EPA0A3N

STAUROSPORINE

INHIBITOR -> TARGET


					9L0Q8KK220

DELGOCITINIB

INHIBITOR -> TARGET


					19J3781LPM

ITACITINIB

INHIBITOR -> TARGET


					KL2Z2TLF01

AZD-1480

INHIBITOR -> TARGET


					4RA0KN46E0

UPADACITINIB

INHIBITOR -> TARGET


					C2J2F95UM8

GDC-4379

INHIBITOR -> TARGET

Amount:


					F4CFC52G5E

ABROCITINIB METABOLITE M4

INHIBITOR -> TARGET

Amount:


					J2Q5XQZ64C

BMS-986202

INHIBITOR->OFF-TARGET

Qualification:

IC50

Amount:


					TE2YU6E6YP

CEP-33779

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					HY5SOV7O0Q

ROPSACITINIB

INHIBITOR->OFF-TARGET

Qualification:

Amount:


					D1LXQ45S1O

CERDULATINIB

INHIBITOR -> TARGET


					IV7H45AM5B

K252A

INHIBITOR -> TARGET


					73SM5SF3OR

ABROCITINIB

INHIBITOR -> TARGET

Comments:

ATP at the apparent Km.

Qualification:

IC50

Amount:


					JAC34RRR7S

Londamocitinib

INHIBITOR -> TARGET

Comments:

Potent and selective Janus Kinase 1 Inhibitor, an inhaled treatment for respiratory disease.

Qualification:

IC50

Amount:


					DO989GC5D1

LESTAURTINIB

INHIBITOR -> TARGET


					HPH1166CKX

PEFICITINIB

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					MZK2GP0RHK

DECERNOTINIB

INHIBITOR -> TARGET


					40D08182TT

ZOTIRACICLIB

INHIBITOR -> TARGET


					87LA6FU830

TOFACITINIB

INHIBITOR -> TARGET


					4L1AM42NVA

XL-019

INHIBITOR -> TARGET


					56R994WX4L

ILGINATINIB

INHIBITOR -> TARGET


					7N5LJ2Z26C

2-N-((1S)-1-(5-FLUOROPYRIMIDIN-2-YL)ETHYL)-4-N-(1-METHYLIMIDAZOL-4-YL)-7H-PYRROLO(2,3-D)PYRIMIDINE-2,4-DIAMINE

INHIBITOR -> TARGET


					82S8X8XX8H

RUXOLITINIB

INHIBITOR -> TARGET


					S6U3J3UP11

SB-218078

INHIBITOR -> TARGET


					2ZT81PV5UM

IZENCITINIB

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					4801QYW816

GUSACITINIB

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					DQN3V3R84U

Lepzacitinib

INHIBITOR -> TARGET

Interaction Type:

IN-VITRO

Amount:


					B9IQO7JZ16

GO-6976

INHIBITOR -> TARGET


					6L1XP550I6

FEDRATINIB

INHIBITOR -> TARGET


					LDX3F0CCST

PYRIDONE-6

INHIBITOR -> TARGET


					ISP4442I3Y

BARICITINIB

INHIBITOR -> TARGET


					0CA0VSF91Y

DEURUXOLITINIB

INHIBITOR -> TARGET

Amount:


					6O01GMS00P

MOMELOTINIB

INHIBITOR -> TARGET

Interaction Type:

COMPETITIVE INHIBITOR

Qualification:

IC50

Amount:


					MXH6JPD2F8

ABROCITINIB METABOLITE M2

INHIBITOR -> TARGET

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER AVERAGE(CALCULATED)	CHEMICAL