TYROSINE-PROTEIN KINASE JAK2

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 12:23:09 GMT 2023` Edited by `admin` on `Sat Dec 16 12:23:09 GMT 2023`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	GL209F9TZS
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

TYROSINE-PROTEIN KINASE JAK2

Common Name

English

JAK-2

Common Name

English

JAK2

Common Name

English

RECEPTOR-ASSOCIATED TYROSINE KINASE (HUMAN GENE JAK2)

Common Name

English

JANUS KINASE 2

Common Name

English

Code System Code Type Description

CAS

479842-25-6

Created by admin on Sat Dec 16 12:23:10 GMT 2023 , Edited by admin on Sat Dec 16 12:23:10 GMT 2023

ALTERNATIVE

FDA UNII

GL209F9TZS

Created by admin on Sat Dec 16 12:23:10 GMT 2023 , Edited by admin on Sat Dec 16 12:23:10 GMT 2023

PRIMARY

CAS

391968-59-5

Created by admin on Sat Dec 16 12:23:10 GMT 2023 , Edited by admin on Sat Dec 16 12:23:10 GMT 2023

PRIMARY

WIKIPEDIA

JANUS KINASE 2

Created by admin on Sat Dec 16 12:23:10 GMT 2023 , Edited by admin on Sat Dec 16 12:23:10 GMT 2023

PRIMARY

UNIPROT

O60674

Created by admin on Sat Dec 16 12:23:10 GMT 2023 , Edited by admin on Sat Dec 16 12:23:10 GMT 2023

PRIMARY

PHAROS

O60674

Created by admin on Sat Dec 16 12:23:10 GMT 2023 , Edited by admin on Sat Dec 16 12:23:10 GMT 2023

PRIMARY

EC (ENZYME CLASS)

EC 2.7.10.2

Created by admin on Sat Dec 16 12:23:10 GMT 2023 , Edited by admin on Sat Dec 16 12:23:10 GMT 2023

PRIMARY

Related Record Type Details


					J8AY0Z4CBP

CEP-11981

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					HY5SOV7O0Q

INHIBITOR->OFF-TARGET

Qualification:

Kd

Amount:


					C4UD8F8XJY

AG-490

INHIBITOR -> TARGET

Comments:

Suppressed IL-4- and IL–13- mediated expression and release of monocyte chemoattractant protein-1 (MCP-1) that influences bronchial hyperreactivity and remodeling in asthma.

Qualification:

IC50

Amount:


					2ZT81PV5UM

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					82S8X8XX8H

INHIBITOR -> TARGET


					M63IS9PTJF

AZ-960

INHIBITOR -> TARGET


					KL2Z2TLF01

AZD-1480

INHIBITOR -> TARGET


					S6U3J3UP11

SB-218078

INHIBITOR -> TARGET


					D1LXQ45S1O

INHIBITOR -> TARGET


					40D08182TT

INHIBITOR -> TARGET


					73SM5SF3OR

INHIBITOR -> TARGET

Comments:

At 1 mM ATP.

Qualification:

IC50

Amount:


					19J3781LPM

INHIBITOR -> TARGET


					ISP4442I3Y

INHIBITOR -> TARGET


					478ZV54680

INHIBITOR -> TARGET


					86YZ7HCC8V

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					MZK2GP0RHK

INHIBITOR -> TARGET


					DO989GC5D1

INHIBITOR -> TARGET

Amount:


					7N03P021J8

INHIBITOR -> TARGET


					LDX3F0CCST

INHIBITOR -> TARGET


					HPH1166CKX

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					LFR1253W75

K-00546

INHIBITOR -> TARGET


					56R994WX4L

INHIBITOR -> TARGET


					9M632G86CC

TPCA-1

INHIBITOR -> TARGET


					6O01GMS00P

INHIBITOR -> TARGET


					G22N65IL3O

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					C0WUS7XXE9

INHIBITOR -> TARGET

Amount:


					ZSA4DW7LDJ

INHIBITOR -> TARGET

Amount:


					XAV9KYN9WL

AT-9283

INHIBITOR -> TARGET


					7N5LJ2Z26C

2-N-((1S)-1-(5-FLUOROPYRIMIDIN-2-YL)ETHYL)-4-N-(1-METHYLIMIDAZOL-4-YL)-7H-PYRROLO(2,3-D)PYRIMIDINE-2,4-DIAMINE

INHIBITOR -> TARGET


					87LA6FU830

INHIBITOR -> TARGET


					4L1AM42NVA

XL-019

INHIBITOR -> TARGET


					6L1XP550I6

INHIBITOR -> TARGET


					3XVL385Q0M

INHIBITOR -> TARGET


					DBA7WU5NH4

TUL-01101

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					87LA6FU830

INHIBITOR -> TARGET


					98KDC0ZGX2

N-(CYANOMETHYL)-4-(2-((4-(3-OXO-4-MORPHOLINYL)PHENYL)AMINO)-4-PYRIMIDINYL)BENZAMIDE

INHIBITOR -> TARGET

Qualification:

EC50

Amount:


					74GK72DON8

INHIBITOR -> TARGET


					H88EPA0A3N

INHIBITOR -> TARGET


					6O01GMS00P

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					JAC34RRR7S

WEAK INHIBITOR->TARGET

Qualification:

IC50

Amount:


					TE2YU6E6YP

CEP-33779

INHIBITOR -> TARGET

Comments:

Performed using a modified GeneBLAzer assay for the CellSensor irf1-bla TF-1 cell line.

Interaction Type:

BIOASSAY (CELLULAR)

Qualification:

IC50

Amount:


					ANC71R916O

INHIBITOR -> TARGET


					4801QYW816

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					0CA0VSF91Y

INHIBITOR -> TARGET

Amount:


					82S8X8XX8H

INHIBITOR -> TARGET


					B9IQO7JZ16

GO-6976

INHIBITOR -> TARGET


					IV7H45AM5B

K252A

INHIBITOR -> TARGET


					ID912S5VON

INHIBITOR -> TARGET

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER AVERAGE(CALCULATED)	CHEMICAL