DORSOMORPHIN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H25N5O
Molecular Weight	399.4882
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of DORSOMORPHIN

Structure Search

SMILES

C(CN1CCCCC1)OC2=CC=C(C=C2)C3=CN4N=CC(=C4N=C3)C5=CC=NC=C5

InChI

InChIKey=XHBVYDAKJHETMP-UHFFFAOYSA-N

InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2

HIDE SMILES / InChI

Molecular Formula	C24H25N5O
Molecular Weight	399.4882
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
Ephrin type-A receptor 2 8 Target ID: CHEMBL2068 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20932747	Inhibitor 8504		11.0 nM [IC50]
Vascular endothelial growth factor receptor 2 112 Target ID: CHEMBL279 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12443771	Inhibitor 8504		20.0 nM [IC50]
Vascular endothelial growth factor receptor 1 44 Target ID: CHEMBL1868 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20932747	Inhibitor 8504		11.0 nM [IC50]
MAP kinase-interacting serine/threonine-protein kinase MNK1 3 Target ID: CHEMBL4718 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20932747	Inhibitor 8504		11.0 nM [IC50]
Tyrosine-protein kinase LCK 14 Target ID: CHEMBL258 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20932747	Inhibitor 8504		16.0 nM [IC50]

Substance Class	Chemical Created by `admin` on `Tue Apr 01 17:37:21 GMT 2025` Edited by `admin` on `Tue Apr 01 17:37:21 GMT 2025`
Record UNII	10K52CIC1Z
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AMPK INHIBITOR, COMPOUND C

Preferred Name

English

DORSOMORPHIN

Common Name

English

6-(4-(2-(1-PIPERIDINYL)ETHOXY)PHENYL)-3-(4-PYRIDINYL)PYRAZOLO(1,5-A)PYRIMIDINE

Systematic Name

English

PYRAZOLO(1,5-A)PYRIMIDINE, 6-(4-(2-(1-PIPERIDINYL)ETHOXY)PHENYL)-3-(4-PYRIDINYL)-

Systematic Name

English

Code System Code Type Description

CAS

866405-64-3

Created by admin on Tue Apr 01 17:37:21 GMT 2025 , Edited by admin on Tue Apr 01 17:37:21 GMT 2025

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DRUG BANK

DB08597

Created by admin on Tue Apr 01 17:37:21 GMT 2025 , Edited by admin on Tue Apr 01 17:37:21 GMT 2025

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PUBCHEM

11524144

Created by admin on Tue Apr 01 17:37:21 GMT 2025 , Edited by admin on Tue Apr 01 17:37:21 GMT 2025

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FDA UNII

10K52CIC1Z

Created by admin on Tue Apr 01 17:37:21 GMT 2025 , Edited by admin on Tue Apr 01 17:37:21 GMT 2025

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EPA CompTox

DTXSID401006988

Created by admin on Tue Apr 01 17:37:21 GMT 2025 , Edited by admin on Tue Apr 01 17:37:21 GMT 2025

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