EPHRIN TYPE-A RECEPTOR 3

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 16:29:18 GMT 2025` Edited by `admin` on `Tue Apr 01 16:29:18 GMT 2025`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	13U1W2G8EZ
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

EPHRIN TYPE-A RECEPTOR 3

Common Name

English

EPH-LIKE KINASE 4

Preferred Name

English

HUMAN EMBRYO KINASE

Common Name

English

EphA3 Kinase

Common Name

English

TYRO4

Common Name

English

ETK1

Common Name

English

HEK

Common Name

English

HEK4

Common Name

English

TYROSINE-PROTEIN KINASE TYRO4

Common Name

English

TYROSINE-PROTEIN KINASE RECEPTOR ETK1

Common Name

English

EphA3

Common Name

English

EPH-LIKE TYROSINE KINASE 1

Common Name

English

Code System Code Type Description

FDA UNII

13U1W2G8EZ

Created by admin on Tue Apr 01 16:29:18 GMT 2025 , Edited by admin on Tue Apr 01 16:29:18 GMT 2025

PRIMARY

PHAROS

P29320

Created by admin on Tue Apr 01 16:29:18 GMT 2025 , Edited by admin on Tue Apr 01 16:29:18 GMT 2025

PRIMARY

EC (ENZYME CLASS)

EC 2.7.10.1

Created by admin on Tue Apr 01 16:29:18 GMT 2025 , Edited by admin on Tue Apr 01 16:29:18 GMT 2025

PRIMARY

WIKIPEDIA

EPH RECEPTOR A3

Created by admin on Tue Apr 01 16:29:18 GMT 2025 , Edited by admin on Tue Apr 01 16:29:18 GMT 2025

PRIMARY

UNIPROT

P29320

Created by admin on Tue Apr 01 16:29:18 GMT 2025 , Edited by admin on Tue Apr 01 16:29:18 GMT 2025

PRIMARY

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_212
N	1_317
N	1_371
N	1_384
N	1_473

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Comments:

EphA3 is an oncofetal antigen with restricted tissue expression, the development of a targeted agent holds promise. Four mechanisms of cell killing have been described: direct induction of apoptosis, activation of antibody-dependent cell-mediated cytotoxicity (ADCC), disruption of tumor vasculature and inhibition of survival signaling from the marrow microenvironment.

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Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_917]		TYROSINE		TYROSINE O-PHOSPHATE	2R86C98KDX
AMINO ACID SUBSTITUTION	[1_576] [1_582] [1_681] [1_759]		TYROSINE		TYROSINE O-PHOSPHATE	2R86C98KDX

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER AVERAGE(CALCULATED)	CHEMICAL