EPHRIN TYPE-A RECEPTOR 3

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 11:30:09 GMT 2023` Edited by `admin` on `Sat Dec 16 11:30:09 GMT 2023`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	13U1W2G8EZ
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

EPHRIN TYPE-A RECEPTOR 3

Common Name

English

HUMAN EMBRYO KINASE

Common Name

English

EphA3 Kinase

Common Name

English

TYRO4

Common Name

English

ETK1

Common Name

English

HEK

Common Name

English

HEK4

Common Name

English

EPH-LIKE KINASE 4

Common Name

English

TYROSINE-PROTEIN KINASE TYRO4

Common Name

English

TYROSINE-PROTEIN KINASE RECEPTOR ETK1

Common Name

English

EphA3

Common Name

English

EPH-LIKE TYROSINE KINASE 1

Common Name

English

Code System Code Type Description

FDA UNII

13U1W2G8EZ

Created by admin on Sat Dec 16 11:30:09 GMT 2023 , Edited by admin on Sat Dec 16 11:30:09 GMT 2023

PRIMARY

PHAROS

P29320

Created by admin on Sat Dec 16 11:30:09 GMT 2023 , Edited by admin on Sat Dec 16 11:30:09 GMT 2023

PRIMARY

EC (ENZYME CLASS)

EC 2.7.10.1

Created by admin on Sat Dec 16 11:30:09 GMT 2023 , Edited by admin on Sat Dec 16 11:30:09 GMT 2023

PRIMARY

WIKIPEDIA

EPH RECEPTOR A3

Created by admin on Sat Dec 16 11:30:09 GMT 2023 , Edited by admin on Sat Dec 16 11:30:09 GMT 2023

PRIMARY

UNIPROT

P29320

Created by admin on Sat Dec 16 11:30:09 GMT 2023 , Edited by admin on Sat Dec 16 11:30:09 GMT 2023

PRIMARY

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_212
N	1_317
N	1_371
N	1_384
N	1_473

Related Record Type Details


					BYW31FWC1X

INHIBITOR -> TARGET


					8S7CMB69GB

1H-Imidazo[2,1-f]purine-2,4(3H,8H)-dione, 7-(5-hydroxy-2-methylphenyl)-8-(2-methoxyphenyl)-1-methyl-

INHIBITOR -> TARGET

Amount:


					234335M86K

WEAK INHIBITOR->TARGET


					H88EPA0A3N

INHIBITOR -> TARGET

Amount:


					YO460OQ37K

INHIBITOR -> TARGET


					F41401512X

NILOTINIB

INHIBITOR -> TARGET


					2BN89552WP

LIGAND->TARGET

Comments:

EphA3 is an oncofetal antigen with restricted tissue expression, the development of a targeted agent holds promise. Four mechanisms of cell killing have been described: direct induction of apoptosis, activation of antibody-dependent cell-mediated cytotoxicity (ADCC), disruption of tumor vasculature and inhibition of survival signaling from the marrow microenvironment.

Amount:


					RBZ1571X5H

DASATINIB

INHIBITOR -> TARGET

Amount:


					10K52CIC1Z

INHIBITOR -> TARGET


					5018V4AEZ0

BOSUTINIB

INHIBITOR -> TARGET

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER AVERAGE(CALCULATED)	CHEMICAL