U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
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Approval Year

Substance Class Protein
Created
by admin
on Tue Apr 01 16:29:18 GMT 2025
Edited
by admin
on Tue Apr 01 16:29:18 GMT 2025
Protein Sub Type
Sequence Type COMPLETE
Record UNII
13U1W2G8EZ
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
EPHRIN TYPE-A RECEPTOR 3
Common Name English
EPH-LIKE KINASE 4
Preferred Name English
HUMAN EMBRYO KINASE
Common Name English
EphA3 Kinase
Common Name English
TYRO4
Common Name English
ETK1
Common Name English
HEK
Common Name English
HEK4
Common Name English
TYROSINE-PROTEIN KINASE TYRO4
Common Name English
TYROSINE-PROTEIN KINASE RECEPTOR ETK1
Common Name English
EphA3
Common Name English
EPH-LIKE TYROSINE KINASE 1
Common Name English
Code System Code Type Description
FDA UNII
13U1W2G8EZ
Created by admin on Tue Apr 01 16:29:18 GMT 2025 , Edited by admin on Tue Apr 01 16:29:18 GMT 2025
PRIMARY
PHAROS
P29320
Created by admin on Tue Apr 01 16:29:18 GMT 2025 , Edited by admin on Tue Apr 01 16:29:18 GMT 2025
PRIMARY
EC (ENZYME CLASS)
EC 2.7.10.1
Created by admin on Tue Apr 01 16:29:18 GMT 2025 , Edited by admin on Tue Apr 01 16:29:18 GMT 2025
PRIMARY
WIKIPEDIA
EPH RECEPTOR A3
Created by admin on Tue Apr 01 16:29:18 GMT 2025 , Edited by admin on Tue Apr 01 16:29:18 GMT 2025
PRIMARY
UNIPROT
P29320
Created by admin on Tue Apr 01 16:29:18 GMT 2025 , Edited by admin on Tue Apr 01 16:29:18 GMT 2025
PRIMARY
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_212
N 1_317
N 1_371
N 1_384
N 1_473
Related Record Type Details
INHIBITOR -> TARGET
INHIBITOR -> TARGET
WEAK INHIBITOR->TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
LIGAND->TARGET
EphA3 is an oncofetal antigen with restricted tissue expression, the development of a targeted agent holds promise. Four mechanisms of cell killing have been described: direct induction of apoptosis, activation of antibody-dependent cell-mediated cytotoxicity (ADCC), disruption of tumor vasculature and inhibition of survival signaling from the marrow microenvironment.
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID SUBSTITUTION [1_917] TYROSINE TYROSINE O-PHOSPHATE 2R86C98KDX
AMINO ACID SUBSTITUTION [1_576] [1_582] [1_681] [1_759] TYROSINE TYROSINE O-PHOSPHATE 2R86C98KDX
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER AVERAGE(CALCULATED) CHEMICAL