Dorsomorphin dihydrochloride

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H25N5O.2ClH
Molecular Weight	472.41
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of Dorsomorphin dihydrochloride

Structure Search

SMILES

Cl.Cl.C(CN1CCCCC1)OC2=CC=C(C=C2)C3=CN4N=CC(=C4N=C3)C5=CC=NC=C5

InChI

InChIKey=RJDVIJJQKMGPMV-UHFFFAOYSA-N

InChI=1S/C24H25N5O.2ClH/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20;;/h4-11,16-18H,1-3,12-15H2;2*1H

HIDE SMILES / InChI

Molecular Formula	C24H25N5O
Molecular Weight	399.4882
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Potency
Ephrin type-A receptor 2 8 Target ID: CHEMBL2068 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20932747	Inhibitor 8504	11.0 nM [IC50]
Vascular endothelial growth factor receptor 2 112 Target ID: CHEMBL279 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12443771	Inhibitor 8504	20.0 nM [IC50]
Vascular endothelial growth factor receptor 1 44 Target ID: CHEMBL1868 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20932747	Inhibitor 8504	11.0 nM [IC50]
MAP kinase-interacting serine/threonine-protein kinase MNK1 3 Target ID: CHEMBL4718 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20932747	Inhibitor 8504	11.0 nM [IC50]
Tyrosine-protein kinase LCK 14 Target ID: CHEMBL258 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20932747	Inhibitor 8504	16.0 nM [IC50]

Substance Class	Chemical Created by `admin` on `Wed Apr 02 19:24:15 GMT 2025` Edited by `admin` on `Wed Apr 02 19:24:15 GMT 2025`
Record UNII	TD4NBA239W
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BML-275

Preferred Name

English

Dorsomorphin dihydrochloride

Common Name

English

Pyrazolo[1,5-a]pyrimidine, 6-[4-[2-(1-piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-, hydrochloride (1:2)

Systematic Name

English

BML275

Code

English

Code System Code Type Description

CAS

1219168-18-9

Created by admin on Wed Apr 02 19:24:15 GMT 2025 , Edited by admin on Wed Apr 02 19:24:15 GMT 2025

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PUBCHEM

49761481

Created by admin on Wed Apr 02 19:24:15 GMT 2025 , Edited by admin on Wed Apr 02 19:24:15 GMT 2025

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FDA UNII

TD4NBA239W

Created by admin on Wed Apr 02 19:24:15 GMT 2025 , Edited by admin on Wed Apr 02 19:24:15 GMT 2025

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