SILVER DIAMMINE FLUORIDE

US Previously Marketed

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	Ag.F.2H3N
Molecular Weight	160.9276
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

N.N.[F-].[Ag+]

InChI

InChIKey=FJKGRAZQBBWYLG-UHFFFAOYSA-M

InChI=1S/Ag.FH.2H3N/h;1H;2*1H3/q+1;;;/p-1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/19278981https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+2930 | https://www.ncbi.nlm.nih.gov/pubmed/11294738https://www.ncbi.nlm.nih.gov/pubmed/26897901https://www.ncbi.nlm.nih.gov/pubmed/25781988The legal airborne permissible exposure limit (PEL) is 11 mg/m^2 averaged over an 8-hour workshift.https://www.ncbi.nlm.nih.gov/pubmed/20429870https://www.purebio.com/assets/001/5202.pdfhttp://google.com/patents/CN102923966B
Curator's Comment: description was created based on several sources, including https://encrypted.google.com/patents/WO2004093793A2

Silver Lactate Monohydrate is odorurless, gray-to-white, light-sensitive crystals, slightly soluble in water and in alcohol. Silver Lactate Monohydrate possess antimicrobial activity and can be used for the manufacture of substrates with antimicrobial activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
cellular response to silver ion 16 Target ID: GO:0071292 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18245232	Substrate 656
tooth mineralization 16 Target ID: GO:0034505 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26897901	Substrate 656
cellular response to silver ion 16 Target ID: GO:0071292 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18245232	Substrate 656
tooth mineralization 16 Target ID: GO:0034505 Sources: https://www.ncbi.nlm.nih.gov/pubmed/24373700	Substrate 656
cellular response to silver ion 16 Target ID: GO:0071292 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18245232	Substrate 656
cellular response to silver ion 16 Target ID: GO:0071292 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18245232	Substrate 656

Conditions

Condition	Modality	Highest Phase	Product
Unknown 2565
Unknown 2565
Dental caries 45 Sources: https://clinicaltrials.gov/ct2/show/NCT01446107	Primary	Approved 8360	Advantage Arrest Silver Diamine Fluoride Approved Use Unknown
Dentinal hypersensitivity 16 Sources: http://health.mo.gov/living/families/oralhealth/pdf/silver-diamine-fluoride.pdf	Primary	Approved 8360	Advantage Arrest Silver Diamine Fluoride Approved Use Unknown
Dental caries 45 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26687774	Primary	Phase I 424	Unknown Approved Use Unknown
Bacterial Infections 63 Sources: https://www.purebio.com/assets/001/5202.pdf	Curative	Not Provided 503	Unknown Approved Use Unknown
Dermatophyte infection 18 Sources: http://www.prnewswire.com/news-releases/pure-bioscience-and-therapeutics-inc-expand-silver-dihydrogen-citrate-pharmaceutical-product-development-initiative-to-include-athletes-foot-nail-fungus-and-antimicrobial-skin-wash-products-55885657.html	Curative	Not Provided 503	Unknown Approved Use Unknown
Unknown 2565
Infections of the mucous membranes 16 Sources: https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~Hcwr0m:1:ther	Primary	Not Provided 503	Colloidal silver iodide Approved Use Solution containing 5 to 49% of colloidal silver iodide have been employed in the treatment of infections of the mucous membranes. Ointments, usually containing 5%, have been used in inflammatory conditions of the eye, ear, and nose.
Inflammatory conditions of the eye, ear, and nose 16 Sources: https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~Hcwr0m:1:ther	Primary	Not Provided 503	Colloidal silver iodide Approved Use Solution containing 5 to 49% of colloidal silver iodide have been employed in the treatment of infections of the mucous membranes. Ointments, usually containing 5%, have been used in inflammatory conditions of the eye, ear, and nose.
Burn 40 Sources: http://reference.medscape.com/drug/silver-nitrate-343589	Palliative	Approved 8360	Unknown Approved Use Antiseptic Wound Cauterization
Ophthalmia neonatorum 16 Sources: https://www.drugs.com/monograph/silver-nitrate.html	Primary	Approved 8360	Unknown Approved Use Prophylaxis of gonococcal ophthalmia neonatorum. AAP recommends use of topical silver nitrate, povidone-iodine, or possibly erythromycin for prophylaxis of nongonococcal nonchlamydial conjunctivitis in neonates, ideally administered shortly after birth.

PubMed

Title	Date	PubMed
Lack of genotoxicity of silver iodide in the SCE assay in vitro, in vivo, and in the Ames/microsome test.	1998	10052565
A chemically intelligent antimicrobial coating for urologic devices.	2000 Feb	10735572
New disinfection and sterilization methods.	2001 Mar-Apr	11294738
Comparative efficacy of hand hygiene agents in the reduction of bacteria and viruses.	2005 Mar	15761405
An alternate technique of care using silver fluoride followed by stannous fluoride in the management of root caries in aged care.	2016 Mar-Apr	26687774
Directional growth of Ag nanorod from polymeric silver cyanide: A potential substrate for concentration dependent SERS signal enhancement leading to melamine detection.	2017 Aug 5	28472744
The antifungal effects and mechanical properties of silver bromide/cationic polymer nano-composite-modified Poly-methyl methacrylate-based dental resin.	2017 May 8	28484255

Patents

Sample Use Guides

In Vivo Use Guide

Lesions, without an accompanying pulp exposure were treated with a solution of 40% silver fluoride for 60 seconds. This was immediately followed by the application of a 10% stannous fluoride paste. A piece of dissolving adhesive wafer was adapted over each treatment site and then allowed to dissolve in the oral fluids. Clinical examination showed that all treated lesions had an uninterrupted black surface 24 hours after treatment.

Route of Administration: Topical

In Vitro Use Guide

Unknown

Name

Type

Language

SILVER DIAMMINE FLUORIDE

Common Name

English

SILVER DIAMINE FLUORIDE

Common Name

English

SILVER DIAMMINE FLUORIDE [JAN]

Common Name

English

DIAMMINE SILVER FLUORIDE

Common Name

English

Diammine silver fluoride [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C28394