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Details

Stereochemistry ACHIRAL
Molecular Formula Ag.F.2H3N
Molecular Weight 160.9276
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SILVER DIAMMINE FLUORIDE

SMILES

N.N.[F-].[Ag+]

InChI

InChIKey=FJKGRAZQBBWYLG-UHFFFAOYSA-M
InChI=1S/Ag.FH.2H3N/h;1H;2*1H3/q+1;;;/p-1

HIDE SMILES / InChI

Molecular Formula Ag
Molecular Weight 107.8682
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula FH
Molecular Weight 20.0063
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula H3N
Molecular Weight 17.0305
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Silver Lactate Monohydrate is odorurless, gray-to-white, light-sensitive crystals, slightly soluble in water and in alcohol. Silver Lactate Monohydrate possess antimicrobial activity and can be used for the manufacture of substrates with antimicrobial activity

Originator

Sources: https://www.ncbi.nlm.nih.gov/pubmed/20429870Vestsi Akademii Navuk BSSR, Seryya Khimichnykh Navuk, Issue 2, Pages 69-73, Journal, 1990
Curator's Comment: The medical uses of silver date back to at least the time of Hippocrates

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Advantage Arrest Silver Diamine Fluoride

Approved Use

Unknown
Primary
Advantage Arrest Silver Diamine Fluoride

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Curative
Unknown

Approved Use

Unknown
Curative
Unknown

Approved Use

Unknown
Primary
Colloidal silver iodide

Approved Use

Solution containing 5 to 49% of colloidal silver iodide have been employed in the treatment of infections of the mucous membranes. Ointments, usually containing 5%, have been used in inflammatory conditions of the eye, ear, and nose.
Primary
Colloidal silver iodide

Approved Use

Solution containing 5 to 49% of colloidal silver iodide have been employed in the treatment of infections of the mucous membranes. Ointments, usually containing 5%, have been used in inflammatory conditions of the eye, ear, and nose.
Palliative
Unknown

Approved Use

Antiseptic Wound Cauterization
Primary
Unknown

Approved Use

Prophylaxis of gonococcal ophthalmia neonatorum. AAP recommends use of topical silver nitrate, povidone-iodine, or possibly erythromycin for prophylaxis of nongonococcal nonchlamydial conjunctivitis in neonates, ideally administered shortly after birth.
PubMed

PubMed

TitleDatePubMed
Lack of genotoxicity of silver iodide in the SCE assay in vitro, in vivo, and in the Ames/microsome test.
1998
Comparative efficacy of hand hygiene agents in the reduction of bacteria and viruses.
2005 Mar
Photocatalytic degradation of pathogenic bacteria with AgI/TiO2 under visible light irradiation.
2007 Apr 24
Antibacterial activity and mechanism of action of the silver ion in Staphylococcus aureus and Escherichia coli.
2008 Apr
Topical antimicrobials for burn wound infections.
2010 Jun
Development of silica-coated silver iodide nanoparticles and their biodistribution.
2012 Dec
A novel silver iodide metalo-drug: experimental and computational modelling assessment of its interaction with intracellular DNA, lipoxygenase and glutathione.
2014 Apr 22
An alternate technique of care using silver fluoride followed by stannous fluoride in the management of root caries in aged care.
2016 Mar-Apr
Directional growth of Ag nanorod from polymeric silver cyanide: A potential substrate for concentration dependent SERS signal enhancement leading to melamine detection.
2017 Aug 5
The antifungal effects and mechanical properties of silver bromide/cationic polymer nano-composite-modified Poly-methyl methacrylate-based dental resin.
2017 May 8
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Toxicity data
Lesions, without an accompanying pulp exposure were treated with a solution of 40% silver fluoride for 60 seconds. This was immediately followed by the application of a 10% stannous fluoride paste. A piece of dissolving adhesive wafer was adapted over each treatment site and then allowed to dissolve in the oral fluids. Clinical examination showed that all treated lesions had an uninterrupted black surface 24 hours after treatment.
Route of Administration: Topical
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Wed Jul 05 23:45:38 UTC 2023
Edited
by admin
on Wed Jul 05 23:45:38 UTC 2023
Record UNII
DDU19UEV1Y
Record Status Validated (UNII)
Record Version
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Name Type Language
SILVER DIAMMINE FLUORIDE
JAN  
Common Name English
SILVER DIAMINE FLUORIDE
Common Name English
SILVER DIAMMINE FLUORIDE [JAN]
Common Name English
DIAMMINE SILVER FLUORIDE
WHO-DD  
Common Name English
Diammine silver fluoride [WHO-DD]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C28394
Created by admin on Wed Jul 05 23:45:38 UTC 2023 , Edited by admin on Wed Jul 05 23:45:38 UTC 2023
Code System Code Type Description
NCI_THESAURUS
C90990
Created by admin on Wed Jul 05 23:45:38 UTC 2023 , Edited by admin on Wed Jul 05 23:45:38 UTC 2023
PRIMARY
PUBCHEM
161820
Created by admin on Wed Jul 05 23:45:38 UTC 2023 , Edited by admin on Wed Jul 05 23:45:38 UTC 2023
PRIMARY
EPA CompTox
DTXSID70955992
Created by admin on Wed Jul 05 23:45:38 UTC 2023 , Edited by admin on Wed Jul 05 23:45:38 UTC 2023
PRIMARY
CHEBI
32129
Created by admin on Wed Jul 05 23:45:38 UTC 2023 , Edited by admin on Wed Jul 05 23:45:38 UTC 2023
PRIMARY
EVMPD
SUB13555MIG
Created by admin on Wed Jul 05 23:45:38 UTC 2023 , Edited by admin on Wed Jul 05 23:45:38 UTC 2023
PRIMARY
MESH
C024633
Created by admin on Wed Jul 05 23:45:38 UTC 2023 , Edited by admin on Wed Jul 05 23:45:38 UTC 2023
PRIMARY
FDA UNII
DDU19UEV1Y
Created by admin on Wed Jul 05 23:45:38 UTC 2023 , Edited by admin on Wed Jul 05 23:45:38 UTC 2023
PRIMARY
CAS
34445-07-3
Created by admin on Wed Jul 05 23:45:38 UTC 2023 , Edited by admin on Wed Jul 05 23:45:38 UTC 2023
PRIMARY
WIKIPEDIA
Silver diammine fluoride
Created by admin on Wed Jul 05 23:45:38 UTC 2023 , Edited by admin on Wed Jul 05 23:45:38 UTC 2023
PRIMARY
SMS_ID
100000079527
Created by admin on Wed Jul 05 23:45:38 UTC 2023 , Edited by admin on Wed Jul 05 23:45:38 UTC 2023
PRIMARY
Related Record Type Details
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