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Details

Stereochemistry ACHIRAL
Molecular Formula C6H18O24P6
Molecular Weight 660.0356
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FYTIC ACID

SMILES

[C@]1([H])([C@@]([H])([C@]([H])([C@@]([H])([C@]([H])([C@@]1([H])OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O

InChI

InChIKey=IMQLKJBTEOYOSI-GPIVLXJGSA-N
InChI=1S/C6H18O24P6/c7-31(8,9)25-1-2(26-32(10,11)12)4(28-34(16,17)18)6(30-36(22,23)24)5(29-35(19,20)21)3(1)27-33(13,14)15/h1-6H,(H2,7,8,9)(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)(H2,19,20,21)(H2,22,23,24)/t1-,2-,3-,4+,5-,6-

HIDE SMILES / InChI

Description
Curator's Comment:: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/16401188 | https://www.ncbi.nlm.nih.gov/pubmed/28233043 | https://www.ncbi.nlm.nih.gov/pubmed/26859648 | https://www.ncbi.nlm.nih.gov/pubmed/20127021

Phytate Sodium is a complex sodium salt of the corn-derived plant component Phytic Acid , that used as a chelating agent in all types of cosmetic products, including soaps, shampoos, balms and leave-on products for the face or body. Phytate Sodium is a biodegradable product and appears in the form of a dark-coloured liquid, is soluble in water and has a characteristic odour. It can be used in all types of cosmetic products, including soaps, shampoos, balms and leave-on products for the face or body. In vivo and in vitro experiments have demonstrated striking anticancer (preventive as well as therapeutic) effects of phytic acid. Research shows anti-carcinogenic effects, albeit to a lesser extent and it acts in inhibiting cancer. In addition to reduction in cell proliferation, phytic acid increases differentiation of malignant cells often resulting in reversion to the normal phenotype. Phytates participation in important intracellular biochemical pathways, normal physiological presence in human cells, tissues, plasma, urine, etc., the levels of which fluctuate with intake, epidemiological correlates of phytate deficiency with disease and reversal of those conditions by adequate intake, and safety – all strongly suggest for phytates inclusion as an essential nutrient, perhaps a vitamin. Phytic acid, mostly as Phytate Sodium or other phytates, is found within the hulls of nuts, seeds, and grains. No detectable phytate (less than 0.02 % of wet weight) was observed in vegetables such as scallion and cabbage leaves or in fruits such as apples, oranges, bananas, or pears. In-home food preparation techniques can break down the phytic acid in all of these foods. Simply cooking the food will reduce the phytic acid to some degree. More effective methods are soaking in an acid medium, sprouting and lactic acid fermentation such as in sourdough and pickling.

Approval Year

TargetsConditions
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
0.12 μg/mL
1400 mg single, oral
dose: 1400 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
FYTIC ACID plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
0.52 μg × h/mL
1400 mg single, oral
dose: 1400 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
FYTIC ACID plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
4 h
1400 mg single, oral
dose: 1400 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
FYTIC ACID plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer

Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
likely
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Development, acceptability and nutritional evaluation of 'Doli Ki Roti'--an indigenously fermented bread.
2001
An expanded view of inositol signaling.
2001
Influence of inositolhexaphosphori acid (phytic acid) on the copper distribution in tissues and the excretion of copper in rats.
2001 Apr
Novel method using phytase for separating soybean beta-conglycinin and glycinin.
2001 Apr
Effect of processing on the nutrients and anti-nutrients of lima bean (Phaseolus lunatus L.) flour.
2001 Apr
Effect of soaking, germination, autoclaving and cooking on chemical and biological value of guar compared with faba bean.
2001 Aug
Inositol hexakisphosphate increases L-type Ca2+ channel activity by stimulation of adenylyl cyclase.
2001 Aug
Study on concretions developed around urinary catheters and mechanisms of renal calculi development.
2001 Aug
Calcium-dependent catalytic activity of a novel phytase from Bacillus amyloliquefaciens DS11.
2001 Aug 14
Nutrient distribution and phenolic antioxidants in air-classified fractions of beach pea (Lathyrus maritimus L.).
2001 Feb
Iron absorption from experimental infant formulas based on pea (Pisum sativum)-protein isolate: the effect of phytic acid and ascorbic acid.
2001 Jan
Nutritional composition of uncommon foods and their role in meeting micronutrient needs.
2001 Jul
Beneficial effects of Rhizopus oligosporus fermentation on reduction of glucosinolates, fibre and phytic acid in rapeseed (Brassica napus) meal.
2001 Jul
Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cells.
2001 Jul 6
G0/G1 arrest and S phase inhibition of human cancer cell lines by inositol hexaphosphate (IP6).
2001 Jul-Aug
Proposed phytic acid standard including a method for its analysis.
2001 Jul-Aug
Accessory spleen in the pelvis diagnosed by Tc-99m phytate scintigraphy.
2001 Jun
Effect of various domestic processing methods on antinutrients and in vitro protein and starch digestibility of two indigenous varieties of Indian tribal pulse, Mucuna pruriens Var. utilis.
2001 Jun
Determination of phytic acid by gas chromatography-mass spectroscopy: application to biological samples.
2001 Jun 15
ATP production from adenine by a self-coupling enzymatic process: high-level accumulation under ammonium-limited conditions.
2001 Mar
Extracellular secretion of Aspergillus phytase from Arabidopsis roots enables plants to obtain phosphorus from phytate.
2001 Mar
A home-based method to reduce phytate content and increase zinc bioavailability in maize-based complementary diets.
2001 Mar
Direct observation of two distinct affinity conformations in the T state human deoxyhemoglobin.
2001 Mar 9
Purification and properties of extracellular phytase from Bacillus sp. KHU-10.
2001 May
Dietary diversification/modification strategies to enhance micronutrient content and bioavailability of diets in developing countries.
2001 May
A physiological manoeuvre to improve the positivity of the gastro-oesophageal reflux scintigraphic test.
2001 May
Prolonged fermentation of whole wheat sourdough reduces phytate level and increases soluble magnesium.
2001 May
Purification and characterization of a phytate-degrading enzyme from germinated faba beans (Vicia faba Var. Alameda).
2001 May
Asbestos causes apoptosis in alveolar epithelial cells: role of iron-induced free radicals.
2001 May
Reaction of oxygen with 6-hydroxydopamine catalyzed by Cu, Fe, Mn, and V complexes: identification of a thermodynamic window for effective metal catalysis.
2001 May 1
Utilisation of phytate phosphorus by rumen bacteria in a semi-continuous culture system (Rusitec) in lactating goats fed on different forage to concentrate ratios.
2001 May-Jun
Biotechnological development of effective phytases for mineral nutrition and environmental protection.
2001 Nov
Bioavailability of cadmium from infant diets in newborn rats.
2001 Nov
Oxidation of polyphenols in phytate-reduced high-tannin cereals: effect on different phenolic groups and on in vitro accessible iron.
2001 Nov
Use of fungal phytase to improve breadmaking performance of whole wheat bread.
2001 Nov
The use of 99mTc-phytate for sentinel node mapping in melanoma, breast cancer and vulvar cancer: a study of 100 cases.
2001 Nov
High and low oxygen affinity conformations of T state hemoglobin.
2001 Nov
Stereospecificity of myo-inositol hexakisphosphate dephosphorylation by a phytate-degrading enzyme of Escherichia coli.
2001 Nov 17
Effects of wheat maturation stage and cooking method on dietary fiber and phytic acid contents of firik, a wheat-based local food.
2001 Oct
Can dietary treatment of non-anemic iron deficiency improve iron status?
2001 Oct
Ingestion of insoluble dietary fibre increased zinc and iron absorption and restored growth rate and zinc absorption suppressed by dietary phytate in rats.
2001 Oct
Seeds for a better future: 'low phytate' grains help to overcome malnutrition and reduce pollution.
2001 Oct
Calcium-binding capacities of different brans under simulated gastrointestinal pH conditions. In vitro study with (45)Ca.
2001 Sep
Effects of phytic acid and xanthotoxin on growth and detoxification in caterpillars.
2001 Sep
Processing of newly released ricebean and fababean cultivars: changes in total and available calcium, iron and phosphorus.
2001 Sep
[In vitro availability of minerals in infant foods with different protein source].
2001 Sep-Oct
Enzymatic characterization of organic phosphorus in animal manure.
2001 Sep-Oct
Preparation of phytate-removed deamidated soybean globulins by ion exchangers and characterization of their calcium-binding ability.
2002 Jan 2
Patents

Sample Use Guides

2,000 - 3,000 mg per day (in two doses)
Route of Administration: Oral
In MC65 cells, 48-72-hour treatment with phytic acid (100 uM) provided complete protection against amyloid precursor protein-C-terminal fragment-induced cytotoxicity by attenuating levels of increased intracellular calcium, hydrogen peroxide, superoxide, Aβ oligomers, and moderately upregulated the expression of autophagy (beclin-1) protein.
Name Type Language
FYTIC ACID
INN   MART.   WHO-DD  
INN  
Official Name English
PHYTIC ACID SOLUTION [USP-RS]
Common Name English
MYO-INOSITOL HEXAKIS(DIHYDROGEN PHOSPHATE)
Common Name English
DERMOFEEL PA-3
Brand Name English
EXFODERM
Brand Name English
ALKALOVERT
Brand Name English
PHYTIC ACID [INCI]
Common Name English
INOSITOL HEXAPHOSPHATE
Common Name English
PHYTIC ACID [MI]
Common Name English
INOSITOL HEXAPHOSPHORIC ACID
Common Name English
PHYTIC ACID
INCI   MI  
INCI  
Official Name English
IP6
Common Name English
PHYTIC ACID SOLUTION
USP-RS  
Common Name English
IP-6
Common Name English
INOSITOLHEXAPHOSPHORIC ACID
Common Name English
NSC-269896
Code English
FYTIC ACID [WHO-DD]
Common Name English
FYTIC ACID [INN]
Common Name English
FYTIC ACID [MART.]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C275
Created by admin on Sat Jun 26 11:04:00 UTC 2021 , Edited by admin on Sat Jun 26 11:04:00 UTC 2021
DSLD 478 (Number of products:51)
Created by admin on Sat Jun 26 11:04:00 UTC 2021 , Edited by admin on Sat Jun 26 11:04:00 UTC 2021
EU-Orphan Drug EU/3/12/1008
Created by admin on Sat Jun 26 11:04:00 UTC 2021 , Edited by admin on Sat Jun 26 11:04:00 UTC 2021
Code System Code Type Description
USP_CATALOG
1537910
Created by admin on Sat Jun 26 11:04:00 UTC 2021 , Edited by admin on Sat Jun 26 11:04:00 UTC 2021
PRIMARY USP-RS
ECHA (EC/EINECS)
201-506-6
Created by admin on Sat Jun 26 11:04:00 UTC 2021 , Edited by admin on Sat Jun 26 11:04:00 UTC 2021
PRIMARY
NCI_THESAURUS
C87652
Created by admin on Sat Jun 26 11:04:00 UTC 2021 , Edited by admin on Sat Jun 26 11:04:00 UTC 2021
PRIMARY
CAS
83-86-3
Created by admin on Sat Jun 26 11:04:00 UTC 2021 , Edited by admin on Sat Jun 26 11:04:00 UTC 2021
PRIMARY
FDA UNII
7IGF0S7R8I
Created by admin on Sat Jun 26 11:04:00 UTC 2021 , Edited by admin on Sat Jun 26 11:04:00 UTC 2021
PRIMARY
MESH
D010833
Created by admin on Sat Jun 26 11:04:00 UTC 2021 , Edited by admin on Sat Jun 26 11:04:00 UTC 2021
PRIMARY
EVMPD
SUB07856MIG
Created by admin on Sat Jun 26 11:04:00 UTC 2021 , Edited by admin on Sat Jun 26 11:04:00 UTC 2021
PRIMARY
INN
1472
Created by admin on Sat Jun 26 11:04:00 UTC 2021 , Edited by admin on Sat Jun 26 11:04:00 UTC 2021
PRIMARY
RXCUI
8302
Created by admin on Sat Jun 26 11:04:00 UTC 2021 , Edited by admin on Sat Jun 26 11:04:00 UTC 2021
PRIMARY RxNorm
DRUG BANK
DB14981
Created by admin on Sat Jun 26 11:04:00 UTC 2021 , Edited by admin on Sat Jun 26 11:04:00 UTC 2021
PRIMARY
WIKIPEDIA
PHYTIC ACID
Created by admin on Sat Jun 26 11:04:00 UTC 2021 , Edited by admin on Sat Jun 26 11:04:00 UTC 2021
PRIMARY
DRUG CENTRAL
3465
Created by admin on Sat Jun 26 11:04:00 UTC 2021 , Edited by admin on Sat Jun 26 11:04:00 UTC 2021
PRIMARY
MERCK INDEX
M8769
Created by admin on Sat Jun 26 11:04:00 UTC 2021 , Edited by admin on Sat Jun 26 11:04:00 UTC 2021
PRIMARY Merck Index
ChEMBL
CHEMBL1233511
Created by admin on Sat Jun 26 11:04:00 UTC 2021 , Edited by admin on Sat Jun 26 11:04:00 UTC 2021
PRIMARY