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Details

Stereochemistry ACHIRAL
Molecular Formula C6H18O24P6
Molecular Weight 660.0353
Optical Activity UNSPECIFIED
Defined Stereocenters 6 / 6
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FYTIC ACID

SMILES

OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H]1OP(O)(O)=O

InChI

InChIKey=IMQLKJBTEOYOSI-GPIVLXJGSA-N
InChI=1S/C6H18O24P6/c7-31(8,9)25-1-2(26-32(10,11)12)4(28-34(16,17)18)6(30-36(22,23)24)5(29-35(19,20)21)3(1)27-33(13,14)15/h1-6H,(H2,7,8,9)(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)(H2,19,20,21)(H2,22,23,24)/t1-,2-,3-,4+,5-,6-

HIDE SMILES / InChI

Description
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/16401188 | https://www.ncbi.nlm.nih.gov/pubmed/28233043 | https://www.ncbi.nlm.nih.gov/pubmed/26859648 | https://www.ncbi.nlm.nih.gov/pubmed/20127021

Phytate Sodium is a complex sodium salt of the corn-derived plant component Phytic Acid , that used as a chelating agent in all types of cosmetic products, including soaps, shampoos, balms and leave-on products for the face or body. Phytate Sodium is a biodegradable product and appears in the form of a dark-coloured liquid, is soluble in water and has a characteristic odour. It can be used in all types of cosmetic products, including soaps, shampoos, balms and leave-on products for the face or body. In vivo and in vitro experiments have demonstrated striking anticancer (preventive as well as therapeutic) effects of phytic acid. Research shows anti-carcinogenic effects, albeit to a lesser extent and it acts in inhibiting cancer. In addition to reduction in cell proliferation, phytic acid increases differentiation of malignant cells often resulting in reversion to the normal phenotype. Phytates participation in important intracellular biochemical pathways, normal physiological presence in human cells, tissues, plasma, urine, etc., the levels of which fluctuate with intake, epidemiological correlates of phytate deficiency with disease and reversal of those conditions by adequate intake, and safety – all strongly suggest for phytates inclusion as an essential nutrient, perhaps a vitamin. Phytic acid, mostly as Phytate Sodium or other phytates, is found within the hulls of nuts, seeds, and grains. No detectable phytate (less than 0.02 % of wet weight) was observed in vegetables such as scallion and cabbage leaves or in fruits such as apples, oranges, bananas, or pears. In-home food preparation techniques can break down the phytic acid in all of these foods. Simply cooking the food will reduce the phytic acid to some degree. More effective methods are soaking in an acid medium, sprouting and lactic acid fermentation such as in sourdough and pickling.

Approval Year

TargetsConditions
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
0.12 μg/mL
1400 mg single, oral
dose: 1400 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
FYTIC ACID plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
0.52 μg × h/mL
1400 mg single, oral
dose: 1400 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
FYTIC ACID plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
4 h
1400 mg single, oral
dose: 1400 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
FYTIC ACID plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer

Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
likely
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
An expanded view of inositol signaling.
2001
Effect of heat processing on in vitro protein digestibility and some chemical properties of African breadfruit (Treculia africana Decne) seeds.
2001
Evaluation of selected food attributes of four advanced lines of ungerminated and germinated Nigerian cowpea (Vigna unguiculata (L.) Walp.).
2001
Signaling in plants.
2001
Increased erythritol production in fed-batch cultures of Torula sp. by controlling glucose concentration.
2001 Apr
Novel method using phytase for separating soybean beta-conglycinin and glycinin.
2001 Apr
Nutritional potential of biochemical components in Galactia longifolia Benth. (Fabaceae).
2001 Apr
Expression of D-myo-inositol-3-phosphate synthase in soybean. Implications for phytic acid biosynthesis.
2001 Apr
Distal ligand reactivity and quaternary structure studies of proximally detached hemoglobins.
2001 Apr 3
Pigs expressing salivary phytase produce low-phosphorus manure.
2001 Aug
GRAB: a physiologic guanine nucleotide exchange factor for Rab3A, which interacts with inositol hexakisphosphate kinase.
2001 Aug 16
Assessment of home-based processing methods to reduce the phytate content and phytate/zinc molar ratio of white maize (Zea mays).
2001 Feb
Iron absorption from experimental infant formulas based on pea (Pisum sativum)-protein isolate: the effect of phytic acid and ascorbic acid.
2001 Jan
Cigarette smoke and asbestos activate poly-ADP-ribose polymerase in alveolar epithelial cells.
2001 Jan
Nutritional composition of uncommon foods and their role in meeting micronutrient needs.
2001 Jul
Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cells.
2001 Jul 6
Determination of phytic acid by gas chromatography-mass spectroscopy: application to biological samples.
2001 Jun 15
ATP production from adenine by a self-coupling enzymatic process: high-level accumulation under ammonium-limited conditions.
2001 Mar
Extracellular secretion of Aspergillus phytase from Arabidopsis roots enables plants to obtain phosphorus from phytate.
2001 Mar
Assessing the omnipotence of inositol hexakisphosphate.
2001 Mar
Direct observation of two distinct affinity conformations in the T state human deoxyhemoglobin.
2001 Mar 9
Purification and properties of extracellular phytase from Bacillus sp. KHU-10.
2001 May
Dietary diversification/modification strategies to enhance micronutrient content and bioavailability of diets in developing countries.
2001 May
A physiological manoeuvre to improve the positivity of the gastro-oesophageal reflux scintigraphic test.
2001 May
Prolonged fermentation of whole wheat sourdough reduces phytate level and increases soluble magnesium.
2001 May
Transgenic mice expressing bacterial phytase as a model for phosphorus pollution control.
2001 May
Phosphorylation of a synaptic vesicle-associated protein by an inositol hexakisphosphate-regulated protein kinase.
2001 May 11
Use of fungal phytase to improve breadmaking performance of whole wheat bread.
2001 Nov
Stereospecificity of myo-inositol hexakisphosphate dephosphorylation by a phytate-degrading enzyme of Escherichia coli.
2001 Nov 17
Effects of wheat maturation stage and cooking method on dietary fiber and phytic acid contents of firik, a wheat-based local food.
2001 Oct
Can dietary treatment of non-anemic iron deficiency improve iron status?
2001 Oct
The response of broilers to the feeding of mash or pelleted diets containing maize of varying particle sizes.
2001 Sep
Processing of newly released ricebean and fababean cultivars: changes in total and available calcium, iron and phosphorus.
2001 Sep
Enzymatic characterization of organic phosphorus in animal manure.
2001 Sep-Oct
Preparation of phytate-removed deamidated soybean globulins by ion exchangers and characterization of their calcium-binding ability.
2002 Jan 2
Phytic Acid: From Antinutritional to Multiple Protection Factor of Organic Systems.
2016 Jun
Patents

Sample Use Guides

2,000 - 3,000 mg per day (in two doses)
Route of Administration: Oral
In MC65 cells, 48-72-hour treatment with phytic acid (100 uM) provided complete protection against amyloid precursor protein-C-terminal fragment-induced cytotoxicity by attenuating levels of increased intracellular calcium, hydrogen peroxide, superoxide, Aβ oligomers, and moderately upregulated the expression of autophagy (beclin-1) protein.
Name Type Language
FYTIC ACID
INN   MART.   WHO-DD  
INN  
Official Name English
PHYTIC ACID SOLUTION [USP-RS]
Common Name English
MYO-INOSITOL HEXAKIS(DIHYDROGEN PHOSPHATE)
Common Name English
DERMOFEEL PA-3
Brand Name English
Fytic acid [WHO-DD]
Common Name English
EXFODERM
Brand Name English
ALKALOVERT
Brand Name English
PHYTIC ACID [INCI]
Common Name English
INOSITOL HEXAPHOSPHATE
Common Name English
PHYTIC ACID [MI]
Common Name English
INOSITOL HEXAPHOSPHORIC ACID
Common Name English
PHYTIC ACID
INCI   MI  
INCI  
Official Name English
IP6
Common Name English
PHYTIC ACID SOLUTION
USP-RS  
Common Name English
IP-6
Common Name English
INOSITOLHEXAPHOSPHORIC ACID
Common Name English
NSC-269896
Code English
fytic acid [INN]
Common Name English
FYTIC ACID [MART.]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C275
Created by admin on Fri Dec 15 16:11:07 UTC 2023 , Edited by admin on Fri Dec 15 16:11:07 UTC 2023
DSLD 478 (Number of products:51)
Created by admin on Fri Dec 15 16:11:07 UTC 2023 , Edited by admin on Fri Dec 15 16:11:07 UTC 2023
EU-Orphan Drug EU/3/12/1008
Created by admin on Fri Dec 15 16:11:07 UTC 2023 , Edited by admin on Fri Dec 15 16:11:07 UTC 2023
Code System Code Type Description
ECHA (EC/EINECS)
201-506-6
Created by admin on Fri Dec 15 16:11:07 UTC 2023 , Edited by admin on Fri Dec 15 16:11:07 UTC 2023
PRIMARY
NCI_THESAURUS
C87652
Created by admin on Fri Dec 15 16:11:07 UTC 2023 , Edited by admin on Fri Dec 15 16:11:07 UTC 2023
PRIMARY
EPA CompTox
DTXSID40889331
Created by admin on Fri Dec 15 16:11:07 UTC 2023 , Edited by admin on Fri Dec 15 16:11:07 UTC 2023
PRIMARY
CAS
83-86-3
Created by admin on Fri Dec 15 16:11:07 UTC 2023 , Edited by admin on Fri Dec 15 16:11:07 UTC 2023
PRIMARY
FDA UNII
7IGF0S7R8I
Created by admin on Fri Dec 15 16:11:07 UTC 2023 , Edited by admin on Fri Dec 15 16:11:07 UTC 2023
PRIMARY
MESH
D010833
Created by admin on Fri Dec 15 16:11:07 UTC 2023 , Edited by admin on Fri Dec 15 16:11:07 UTC 2023
PRIMARY
EVMPD
SUB07856MIG
Created by admin on Fri Dec 15 16:11:07 UTC 2023 , Edited by admin on Fri Dec 15 16:11:07 UTC 2023
PRIMARY
SMS_ID
100000084487
Created by admin on Fri Dec 15 16:11:07 UTC 2023 , Edited by admin on Fri Dec 15 16:11:07 UTC 2023
PRIMARY
NSC
269896
Created by admin on Fri Dec 15 16:11:07 UTC 2023 , Edited by admin on Fri Dec 15 16:11:07 UTC 2023
PRIMARY
INN
1472
Created by admin on Fri Dec 15 16:11:07 UTC 2023 , Edited by admin on Fri Dec 15 16:11:07 UTC 2023
PRIMARY
RXCUI
8302
Created by admin on Fri Dec 15 16:11:07 UTC 2023 , Edited by admin on Fri Dec 15 16:11:07 UTC 2023
PRIMARY RxNorm
CHEBI
17401
Created by admin on Fri Dec 15 16:11:07 UTC 2023 , Edited by admin on Fri Dec 15 16:11:07 UTC 2023
PRIMARY
DRUG BANK
DB14981
Created by admin on Fri Dec 15 16:11:07 UTC 2023 , Edited by admin on Fri Dec 15 16:11:07 UTC 2023
PRIMARY
WIKIPEDIA
PHYTIC ACID
Created by admin on Fri Dec 15 16:11:07 UTC 2023 , Edited by admin on Fri Dec 15 16:11:07 UTC 2023
PRIMARY
DAILYMED
7IGF0S7R8I
Created by admin on Fri Dec 15 16:11:07 UTC 2023 , Edited by admin on Fri Dec 15 16:11:07 UTC 2023
PRIMARY
DRUG CENTRAL
3465
Created by admin on Fri Dec 15 16:11:07 UTC 2023 , Edited by admin on Fri Dec 15 16:11:07 UTC 2023
PRIMARY
GRAS Notification (GRN No.)
381
Created by admin on Fri Dec 15 16:11:07 UTC 2023 , Edited by admin on Fri Dec 15 16:11:07 UTC 2023
PRIMARY
RS_ITEM_NUM
1537910
Created by admin on Fri Dec 15 16:11:07 UTC 2023 , Edited by admin on Fri Dec 15 16:11:07 UTC 2023
PRIMARY
MERCK INDEX
m8769
Created by admin on Fri Dec 15 16:11:07 UTC 2023 , Edited by admin on Fri Dec 15 16:11:07 UTC 2023
PRIMARY Merck Index
ChEMBL
CHEMBL1233511
Created by admin on Fri Dec 15 16:11:07 UTC 2023 , Edited by admin on Fri Dec 15 16:11:07 UTC 2023
PRIMARY