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Details

Stereochemistry ACHIRAL
Molecular Formula C6H18O24P6
Molecular Weight 660.0353
Optical Activity UNSPECIFIED
Defined Stereocenters 6 / 6
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FYTIC ACID

SMILES

OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H]1OP(O)(O)=O

InChI

InChIKey=IMQLKJBTEOYOSI-GPIVLXJGSA-N
InChI=1S/C6H18O24P6/c7-31(8,9)25-1-2(26-32(10,11)12)4(28-34(16,17)18)6(30-36(22,23)24)5(29-35(19,20)21)3(1)27-33(13,14)15/h1-6H,(H2,7,8,9)(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)(H2,19,20,21)(H2,22,23,24)/t1-,2-,3-,4+,5-,6-

HIDE SMILES / InChI

Molecular Formula C6H18O24P6
Molecular Weight 660.0353
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 6 / 6
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/16401188 | https://www.ncbi.nlm.nih.gov/pubmed/28233043 | https://www.ncbi.nlm.nih.gov/pubmed/26859648 | https://www.ncbi.nlm.nih.gov/pubmed/20127021

Phytate Sodium is a complex sodium salt of the corn-derived plant component Phytic Acid , that used as a chelating agent in all types of cosmetic products, including soaps, shampoos, balms and leave-on products for the face or body. Phytate Sodium is a biodegradable product and appears in the form of a dark-coloured liquid, is soluble in water and has a characteristic odour. It can be used in all types of cosmetic products, including soaps, shampoos, balms and leave-on products for the face or body. In vivo and in vitro experiments have demonstrated striking anticancer (preventive as well as therapeutic) effects of phytic acid. Research shows anti-carcinogenic effects, albeit to a lesser extent and it acts in inhibiting cancer. In addition to reduction in cell proliferation, phytic acid increases differentiation of malignant cells often resulting in reversion to the normal phenotype. Phytates participation in important intracellular biochemical pathways, normal physiological presence in human cells, tissues, plasma, urine, etc., the levels of which fluctuate with intake, epidemiological correlates of phytate deficiency with disease and reversal of those conditions by adequate intake, and safety – all strongly suggest for phytates inclusion as an essential nutrient, perhaps a vitamin. Phytic acid, mostly as Phytate Sodium or other phytates, is found within the hulls of nuts, seeds, and grains. No detectable phytate (less than 0.02 % of wet weight) was observed in vegetables such as scallion and cabbage leaves or in fruits such as apples, oranges, bananas, or pears. In-home food preparation techniques can break down the phytic acid in all of these foods. Simply cooking the food will reduce the phytic acid to some degree. More effective methods are soaking in an acid medium, sprouting and lactic acid fermentation such as in sourdough and pickling.

Approval Year

TargetsConditions
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
0.12 μg/mL
1400 mg single, oral
dose: 1400 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
FYTIC ACID plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
0.52 μg × h/mL
1400 mg single, oral
dose: 1400 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
FYTIC ACID plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
4 h
1400 mg single, oral
dose: 1400 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
FYTIC ACID plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer

Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
likely
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Absorption and excretion of orally administered inositol hexaphosphate (IP(6) or phytate) in humans.
2001
Sentinel lymph node biopsy in breast cancer: an overview of the Japanese experience.
2001
An expanded view of inositol signaling.
2001
Novel method using phytase for separating soybean beta-conglycinin and glycinin.
2001 Apr
Calcium-dependent catalytic activity of a novel phytase from Bacillus amyloliquefaciens DS11.
2001 Aug 14
Cigarette smoke and asbestos activate poly-ADP-ribose polymerase in alveolar epithelial cells.
2001 Jan
[Phytin efficacy in correction of the impaired detoxication liver function in the long-term compression syndrome in rats in prepubertal period].
2001 Jan-Feb
Inositol hexaphosphate inhibits ultraviolet B-induced signal transduction.
2001 Jul
Effect of several germination conditions on total P, phytate P, phytase, and acid phosphatase activities and inositol phosphate esters in rye and barley.
2001 Jul
Beneficial effects of Rhizopus oligosporus fermentation on reduction of glucosinolates, fibre and phytic acid in rapeseed (Brassica napus) meal.
2001 Jul
Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cells.
2001 Jul 6
[New strains of soil bacilli which mineralize organic phosphorus compounds].
2001 Jul-Aug
Proposed phytic acid standard including a method for its analysis.
2001 Jul-Aug
Assessing the omnipotence of inositol hexakisphosphate.
2001 Mar
The use of near-infrared reflectance spectroscopy to predict the moisture, nitrogen, calcium, total phosphorus, gross energy, and phytate phosphorus contents of broiler excreta.
2001 Mar
Purification and properties of extracellular phytase from Bacillus sp. KHU-10.
2001 May
Asbestos causes apoptosis in alveolar epithelial cells: role of iron-induced free radicals.
2001 May
Biotechnological development of effective phytases for mineral nutrition and environmental protection.
2001 Nov
Bioavailability of cadmium from infant diets in newborn rats.
2001 Nov
Oxidation of polyphenols in phytate-reduced high-tannin cereals: effect on different phenolic groups and on in vitro accessible iron.
2001 Nov
The use of 99mTc-phytate for sentinel node mapping in melanoma, breast cancer and vulvar cancer: a study of 100 cases.
2001 Nov
High and low oxygen affinity conformations of T state hemoglobin.
2001 Nov
Micronutrient composition and nutritional importance of gathered vegetables in Vietnam.
2001 Nov
Molecular dynamics analysis of a second phosphate site in the hemoglobins of the seabird, south polar skua. Is there a site-site migratory mechanism along the central cavity?
2001 Oct
Organic phosphates as a new class of soluble guanylate cyclase inhibitors.
2001 Oct 19
Enzyme mechanism and catalytic property of beta propeller phytase.
2001 Sep
Calcium-binding capacities of different brans under simulated gastrointestinal pH conditions. In vitro study with (45)Ca.
2001 Sep
[In vitro availability of minerals in infant foods with different protein source].
2001 Sep-Oct
Phytic Acid: From Antinutritional to Multiple Protection Factor of Organic Systems.
2016 Jun
Patents

Sample Use Guides

2,000 - 3,000 mg per day (in two doses)
Route of Administration: Oral
In MC65 cells, 48-72-hour treatment with phytic acid (100 uM) provided complete protection against amyloid precursor protein-C-terminal fragment-induced cytotoxicity by attenuating levels of increased intracellular calcium, hydrogen peroxide, superoxide, Aβ oligomers, and moderately upregulated the expression of autophagy (beclin-1) protein.
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:11:07 GMT 2023
Edited
by admin
on Fri Dec 15 16:11:07 GMT 2023
Record UNII
7IGF0S7R8I
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FYTIC ACID
INN   MART.   WHO-DD  
INN  
Official Name English
PHYTIC ACID SOLUTION [USP-RS]
Common Name English
MYO-INOSITOL HEXAKIS(DIHYDROGEN PHOSPHATE)
Common Name English
DERMOFEEL PA-3
Brand Name English
Fytic acid [WHO-DD]
Common Name English
EXFODERM
Brand Name English
ALKALOVERT
Brand Name English
PHYTIC ACID [INCI]
Common Name English
INOSITOL HEXAPHOSPHATE
Common Name English
PHYTIC ACID [MI]
Common Name English
INOSITOL HEXAPHOSPHORIC ACID
Common Name English
PHYTIC ACID
INCI   MI  
INCI  
Official Name English
IP6
Common Name English
PHYTIC ACID SOLUTION
USP-RS  
Common Name English
IP-6
Common Name English
INOSITOLHEXAPHOSPHORIC ACID
Common Name English
NSC-269896
Code English
fytic acid [INN]
Common Name English
FYTIC ACID [MART.]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C275
Created by admin on Fri Dec 15 16:11:07 GMT 2023 , Edited by admin on Fri Dec 15 16:11:07 GMT 2023
DSLD 478 (Number of products:51)
Created by admin on Fri Dec 15 16:11:07 GMT 2023 , Edited by admin on Fri Dec 15 16:11:07 GMT 2023
EU-Orphan Drug EU/3/12/1008
Created by admin on Fri Dec 15 16:11:07 GMT 2023 , Edited by admin on Fri Dec 15 16:11:07 GMT 2023
Code System Code Type Description
ECHA (EC/EINECS)
201-506-6
Created by admin on Fri Dec 15 16:11:07 GMT 2023 , Edited by admin on Fri Dec 15 16:11:07 GMT 2023
PRIMARY
NCI_THESAURUS
C87652
Created by admin on Fri Dec 15 16:11:07 GMT 2023 , Edited by admin on Fri Dec 15 16:11:07 GMT 2023
PRIMARY
EPA CompTox
DTXSID40889331
Created by admin on Fri Dec 15 16:11:07 GMT 2023 , Edited by admin on Fri Dec 15 16:11:07 GMT 2023
PRIMARY
CAS
83-86-3
Created by admin on Fri Dec 15 16:11:07 GMT 2023 , Edited by admin on Fri Dec 15 16:11:07 GMT 2023
PRIMARY
FDA UNII
7IGF0S7R8I
Created by admin on Fri Dec 15 16:11:07 GMT 2023 , Edited by admin on Fri Dec 15 16:11:07 GMT 2023
PRIMARY
MESH
D010833
Created by admin on Fri Dec 15 16:11:07 GMT 2023 , Edited by admin on Fri Dec 15 16:11:07 GMT 2023
PRIMARY
EVMPD
SUB07856MIG
Created by admin on Fri Dec 15 16:11:07 GMT 2023 , Edited by admin on Fri Dec 15 16:11:07 GMT 2023
PRIMARY
SMS_ID
100000084487
Created by admin on Fri Dec 15 16:11:07 GMT 2023 , Edited by admin on Fri Dec 15 16:11:07 GMT 2023
PRIMARY
NSC
269896
Created by admin on Fri Dec 15 16:11:07 GMT 2023 , Edited by admin on Fri Dec 15 16:11:07 GMT 2023
PRIMARY
INN
1472
Created by admin on Fri Dec 15 16:11:07 GMT 2023 , Edited by admin on Fri Dec 15 16:11:07 GMT 2023
PRIMARY
RXCUI
8302
Created by admin on Fri Dec 15 16:11:07 GMT 2023 , Edited by admin on Fri Dec 15 16:11:07 GMT 2023
PRIMARY RxNorm
CHEBI
17401
Created by admin on Fri Dec 15 16:11:07 GMT 2023 , Edited by admin on Fri Dec 15 16:11:07 GMT 2023
PRIMARY
DRUG BANK
DB14981
Created by admin on Fri Dec 15 16:11:07 GMT 2023 , Edited by admin on Fri Dec 15 16:11:07 GMT 2023
PRIMARY
WIKIPEDIA
PHYTIC ACID
Created by admin on Fri Dec 15 16:11:07 GMT 2023 , Edited by admin on Fri Dec 15 16:11:07 GMT 2023
PRIMARY
DAILYMED
7IGF0S7R8I
Created by admin on Fri Dec 15 16:11:07 GMT 2023 , Edited by admin on Fri Dec 15 16:11:07 GMT 2023
PRIMARY
DRUG CENTRAL
3465
Created by admin on Fri Dec 15 16:11:07 GMT 2023 , Edited by admin on Fri Dec 15 16:11:07 GMT 2023
PRIMARY
GRAS Notification (GRN No.)
381
Created by admin on Fri Dec 15 16:11:07 GMT 2023 , Edited by admin on Fri Dec 15 16:11:07 GMT 2023
PRIMARY
RS_ITEM_NUM
1537910
Created by admin on Fri Dec 15 16:11:07 GMT 2023 , Edited by admin on Fri Dec 15 16:11:07 GMT 2023
PRIMARY
MERCK INDEX
m8769
Created by admin on Fri Dec 15 16:11:07 GMT 2023 , Edited by admin on Fri Dec 15 16:11:07 GMT 2023
PRIMARY Merck Index
ChEMBL
CHEMBL1233511
Created by admin on Fri Dec 15 16:11:07 GMT 2023 , Edited by admin on Fri Dec 15 16:11:07 GMT 2023
PRIMARY
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