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Details

Stereochemistry ACHIRAL
Molecular Formula C6H6O24P6.12Na
Molecular Weight 923.8172
Optical Activity UNSPECIFIED
Defined Stereocenters 6 / 6
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PHYTATE PERSODIUM

SMILES

[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)O[C@@H]1[C@H](OP([O-])([O-])=O)[C@H](OP([O-])([O-])=O)[C@@H](OP([O-])([O-])=O)[C@H](OP([O-])([O-])=O)[C@H]1OP([O-])([O-])=O

InChI

InChIKey=KETSPIPODMGOEJ-WTSIVQAUSA-B
InChI=1S/C6H18O24P6.12Na/c7-31(8,9)25-1-2(26-32(10,11)12)4(28-34(16,17)18)6(30-36(22,23)24)5(29-35(19,20)21)3(1)27-33(13,14)15;;;;;;;;;;;;/h1-6H,(H2,7,8,9)(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)(H2,19,20,21)(H2,22,23,24);;;;;;;;;;;;/q;12*+1/p-12/t1-,2-,3-,4+,5-,6-;;;;;;;;;;;;

HIDE SMILES / InChI

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C6H6O24P6
Molecular Weight 647.94
Charge -12
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 6 / 6
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/16401188 | https://www.ncbi.nlm.nih.gov/pubmed/28233043 | https://www.ncbi.nlm.nih.gov/pubmed/26859648 | https://www.ncbi.nlm.nih.gov/pubmed/20127021

Phytate Sodium is a complex sodium salt of the corn-derived plant component Phytic Acid , that used as a chelating agent in all types of cosmetic products, including soaps, shampoos, balms and leave-on products for the face or body. Phytate Sodium is a biodegradable product and appears in the form of a dark-coloured liquid, is soluble in water and has a characteristic odour. It can be used in all types of cosmetic products, including soaps, shampoos, balms and leave-on products for the face or body. In vivo and in vitro experiments have demonstrated striking anticancer (preventive as well as therapeutic) effects of phytic acid. Research shows anti-carcinogenic effects, albeit to a lesser extent and it acts in inhibiting cancer. In addition to reduction in cell proliferation, phytic acid increases differentiation of malignant cells often resulting in reversion to the normal phenotype. Phytates participation in important intracellular biochemical pathways, normal physiological presence in human cells, tissues, plasma, urine, etc., the levels of which fluctuate with intake, epidemiological correlates of phytate deficiency with disease and reversal of those conditions by adequate intake, and safety – all strongly suggest for phytates inclusion as an essential nutrient, perhaps a vitamin. Phytic acid, mostly as Phytate Sodium or other phytates, is found within the hulls of nuts, seeds, and grains. No detectable phytate (less than 0.02 % of wet weight) was observed in vegetables such as scallion and cabbage leaves or in fruits such as apples, oranges, bananas, or pears. In-home food preparation techniques can break down the phytic acid in all of these foods. Simply cooking the food will reduce the phytic acid to some degree. More effective methods are soaking in an acid medium, sprouting and lactic acid fermentation such as in sourdough and pickling.

Approval Year

TargetsConditions
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
0.12 μg/mL
1400 mg single, oral
dose: 1400 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
FYTIC ACID plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
0.52 μg × h/mL
1400 mg single, oral
dose: 1400 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
FYTIC ACID plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
4 h
1400 mg single, oral
dose: 1400 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
FYTIC ACID plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer

Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
likely
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
A case of diaphragm hernia containing accessory spleen and great omentum detected by Tc-99m phytate scintigraphy.
1999 Oct
Development, acceptability and nutritional evaluation of 'Doli Ki Roti'--an indigenously fermented bread.
2001
Absorption and excretion of orally administered inositol hexaphosphate (IP(6) or phytate) in humans.
2001
Sentinel lymph node biopsy in breast cancer: an overview of the Japanese experience.
2001
Soybeans and cancer prevention: a complex food and a complex disease.
2001
Effect of heat processing on in vitro protein digestibility and some chemical properties of African breadfruit (Treculia africana Decne) seeds.
2001
Novel method using phytase for separating soybean beta-conglycinin and glycinin.
2001 Apr
Nutritional potential of biochemical components in Galactia longifolia Benth. (Fabaceae).
2001 Apr
Effect of processing on the nutrients and anti-nutrients of lima bean (Phaseolus lunatus L.) flour.
2001 Apr
Effect of soaking, germination, autoclaving and cooking on chemical and biological value of guar compared with faba bean.
2001 Aug
In vitro availability of zinc from infant foods with increasing phytic acid contents.
2001 Aug
Calcium-dependent catalytic activity of a novel phytase from Bacillus amyloliquefaciens DS11.
2001 Aug 14
GRAB: a physiologic guanine nucleotide exchange factor for Rab3A, which interacts with inositol hexakisphosphate kinase.
2001 Aug 16
Assessment of home-based processing methods to reduce the phytate content and phytate/zinc molar ratio of white maize (Zea mays).
2001 Feb
Problems associated with measuring phytate in infant cereals.
2001 Feb
Inositol hexaphosphate inhibits ultraviolet B-induced signal transduction.
2001 Jul
Nutritional composition of uncommon foods and their role in meeting micronutrient needs.
2001 Jul
G0/G1 arrest and S phase inhibition of human cancer cell lines by inositol hexaphosphate (IP6).
2001 Jul-Aug
[New strains of soil bacilli which mineralize organic phosphorus compounds].
2001 Jul-Aug
Proposed phytic acid standard including a method for its analysis.
2001 Jul-Aug
Accessory spleen in the pelvis diagnosed by Tc-99m phytate scintigraphy.
2001 Jun
Development and sensory evaluation of soy milk based yoghurt.
2001 Mar
Extracellular secretion of Aspergillus phytase from Arabidopsis roots enables plants to obtain phosphorus from phytate.
2001 Mar
Production process for high-quality pea-protein isolate with low content of oligosaccharides and phytate.
2001 Mar
Assessing the omnipotence of inositol hexakisphosphate.
2001 Mar
The use of near-infrared reflectance spectroscopy to predict the moisture, nitrogen, calcium, total phosphorus, gross energy, and phytate phosphorus contents of broiler excreta.
2001 Mar
Inositol phosphates from barley low-phytate grain mutants analysed by metal-dye detection HPLC and NMR.
2001 Mar 1
Reduction by phytate-reduced soybean beta-conglycinin of plasma triglyceride level of young and adult rats.
2001 May
Purification and characterization of a phytate-degrading enzyme from germinated faba beans (Vicia faba Var. Alameda).
2001 May
Transgenic mice expressing bacterial phytase as a model for phosphorus pollution control.
2001 May
Reaction of oxygen with 6-hydroxydopamine catalyzed by Cu, Fe, Mn, and V complexes: identification of a thermodynamic window for effective metal catalysis.
2001 May 1
Utilisation of phytate phosphorus by rumen bacteria in a semi-continuous culture system (Rusitec) in lactating goats fed on different forage to concentrate ratios.
2001 May-Jun
Biotechnological development of effective phytases for mineral nutrition and environmental protection.
2001 Nov
Bioavailability of cadmium from infant diets in newborn rats.
2001 Nov
Oxidation of polyphenols in phytate-reduced high-tannin cereals: effect on different phenolic groups and on in vitro accessible iron.
2001 Nov
Use of fungal phytase to improve breadmaking performance of whole wheat bread.
2001 Nov
The use of 99mTc-phytate for sentinel node mapping in melanoma, breast cancer and vulvar cancer: a study of 100 cases.
2001 Nov
The role of hepatobiliary scintigraphy in the follow-up of benign liver tumors secondary to oral contraceptive use.
2001 Nov
High affinity association of myo-inositol trisphosphates with phytase and its effect upon the catalytic potential of the enzyme.
2001 Nov 23
Effects of wheat maturation stage and cooking method on dietary fiber and phytic acid contents of firik, a wheat-based local food.
2001 Oct
Can dietary treatment of non-anemic iron deficiency improve iron status?
2001 Oct
Enzyme mechanism and catalytic property of beta propeller phytase.
2001 Sep
Effects of phytic acid and xanthotoxin on growth and detoxification in caterpillars.
2001 Sep
Processing of newly released ricebean and fababean cultivars: changes in total and available calcium, iron and phosphorus.
2001 Sep
[In vitro availability of minerals in infant foods with different protein source].
2001 Sep-Oct
Preparation of phytate-removed deamidated soybean globulins by ion exchangers and characterization of their calcium-binding ability.
2002 Jan 2
Patents

Sample Use Guides

2,000 - 3,000 mg per day (in two doses)
Route of Administration: Oral
In MC65 cells, 48-72-hour treatment with phytic acid (100 uM) provided complete protection against amyloid precursor protein-C-terminal fragment-induced cytotoxicity by attenuating levels of increased intracellular calcium, hydrogen peroxide, superoxide, Aβ oligomers, and moderately upregulated the expression of autophagy (beclin-1) protein.
Substance Class Chemical
Created
by admin
on Sat Dec 16 06:58:23 GMT 2023
Edited
by admin
on Sat Dec 16 06:58:23 GMT 2023
Record UNII
3F6PM8J684
Record Status Validated (UNII)
Record Version
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Name Type Language
PHYTATE PERSODIUM
USAN  
USAN  
Official Name English
PHYTATE PERSODIUM [USAN]
Common Name English
DODECASODIUM PHYTATE
Common Name English
MYO-INOSITOL, 1,2,3,4,5,6-HEXAKIS(DIHYDROGEN PHOSPHATE), SODIUM SALT (1:12)
Common Name English
SODIUM FYTATE (12:1)
Common Name English
Code System Code Type Description
NCI_THESAURUS
C167212
Created by admin on Sat Dec 16 06:58:23 GMT 2023 , Edited by admin on Sat Dec 16 06:58:23 GMT 2023
PRIMARY
FDA UNII
3F6PM8J684
Created by admin on Sat Dec 16 06:58:23 GMT 2023 , Edited by admin on Sat Dec 16 06:58:23 GMT 2023
PRIMARY
CAS
17211-15-3
Created by admin on Sat Dec 16 06:58:23 GMT 2023 , Edited by admin on Sat Dec 16 06:58:23 GMT 2023
PRIMARY
PUBCHEM
66391
Created by admin on Sat Dec 16 06:58:23 GMT 2023 , Edited by admin on Sat Dec 16 06:58:23 GMT 2023
PRIMARY
EPA CompTox
DTXSID00938091
Created by admin on Sat Dec 16 06:58:23 GMT 2023 , Edited by admin on Sat Dec 16 06:58:23 GMT 2023
PRIMARY
ChEMBL
CHEMBL1233511
Created by admin on Sat Dec 16 06:58:23 GMT 2023 , Edited by admin on Sat Dec 16 06:58:23 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY