Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C6H6O24P6.12Na |
| Molecular Weight | 923.8172 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 6 / 6 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)O[C@@H]1[C@H](OP([O-])([O-])=O)[C@H](OP([O-])([O-])=O)[C@@H](OP([O-])([O-])=O)[C@H](OP([O-])([O-])=O)[C@H]1OP([O-])([O-])=O
InChI
InChIKey=KETSPIPODMGOEJ-WTSIVQAUSA-B
InChI=1S/C6H18O24P6.12Na/c7-31(8,9)25-1-2(26-32(10,11)12)4(28-34(16,17)18)6(30-36(22,23)24)5(29-35(19,20)21)3(1)27-33(13,14)15;;;;;;;;;;;;/h1-6H,(H2,7,8,9)(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)(H2,19,20,21)(H2,22,23,24);;;;;;;;;;;;/q;12*+1/p-12/t1-,2-,3-,4+,5-,6-;;;;;;;;;;;;
| Molecular Formula | C6H6O24P6 |
| Molecular Weight | 647.94 |
| Charge | -12 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 6 / 6 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
| Molecular Formula | Na |
| Molecular Weight | 22.9898 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionCurator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/16401188 | https://www.ncbi.nlm.nih.gov/pubmed/28233043 | https://www.ncbi.nlm.nih.gov/pubmed/26859648 | https://www.ncbi.nlm.nih.gov/pubmed/20127021
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/16401188 | https://www.ncbi.nlm.nih.gov/pubmed/28233043 | https://www.ncbi.nlm.nih.gov/pubmed/26859648 | https://www.ncbi.nlm.nih.gov/pubmed/20127021
Phytate Sodium is a complex sodium salt of the corn-derived plant component Phytic Acid , that used as a chelating agent in all types of cosmetic products, including soaps, shampoos, balms and leave-on products for the face or body. Phytate Sodium is a biodegradable product and appears in the form of a dark-coloured liquid, is soluble in water and has a characteristic odour. It can be used in all types of cosmetic products, including soaps, shampoos, balms and leave-on products for the face or body. In vivo and in vitro experiments have demonstrated striking anticancer (preventive as well as therapeutic) effects of phytic acid. Research shows anti-carcinogenic effects, albeit to a lesser extent and it acts in inhibiting cancer. In addition to reduction in cell proliferation, phytic acid increases differentiation of malignant cells often resulting in reversion to the normal phenotype. Phytates participation in important intracellular biochemical pathways, normal physiological presence in human cells, tissues, plasma, urine, etc., the levels of which fluctuate with intake, epidemiological correlates of phytate deficiency with disease and reversal of those conditions by adequate intake, and safety – all strongly suggest for phytates inclusion as an essential nutrient, perhaps a vitamin. Phytic acid, mostly as Phytate Sodium or other phytates, is found within the hulls of nuts, seeds, and grains. No detectable phytate (less than 0.02 % of wet weight) was observed in vegetables such as scallion and cabbage leaves or in fruits such as apples, oranges, bananas, or pears. In-home food preparation techniques can break down the phytic acid in all of these foods. Simply cooking the food will reduce the phytic acid to some degree. More effective methods are soaking in an acid medium, sprouting and lactic acid fermentation such as in sourdough and pickling.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: GO:0034440 |
|||
Target ID: Metals (Iron, Zinc) |
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Target ID: AP2 complex |
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Target ID: CHEMBL2363056 |
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Target ID: CHEMBL2364030 |
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Target ID: GO:0055065 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Palliative | Unknown Approved UseUnknown |
|||
| Preventing | Unknown Approved UseUnknown |
|||
Sources: DOI: 10.1046/j.1365-2621.2002.00620.x |
Preventing | Unknown Approved UseUnknown |
||
| Primary | Unknown Approved UseUnknown |
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| Primary | Unknown Approved UseUnknown |
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| Primary | Unknown Approved UseUnknown |
|||
Sources: http://www.nutrientsreview.com/phytonutrients/phytic-acid-inositol-hexaphosphate.html https://www.accessdata.fda.gov/scripts/fdcc/index.cfm?set=grasnotices&id=381 https://naturellecosmetics.com/iblog/reasons-for-phytic-acid-use-in-natural-cosmetics http://www.biosiltech.com/pdf/Phytic%20Acid%20Extreme%20-%20Data%20Sheet%202017.pdf http://www.biosiltech.com/pdf/new_formula_sheets/Phytic%20Acid%20Resurfacing%20Toner%20PS1-301.pdf |
Primary | Unknown Approved UseUnknown |
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
0.12 μg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11673644/ |
1400 mg single, oral dose: 1400 mg route of administration: Oral experiment type: SINGLE co-administered: |
FYTIC ACID plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
AUC
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
0.52 μg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11673644/ |
1400 mg single, oral dose: 1400 mg route of administration: Oral experiment type: SINGLE co-administered: |
FYTIC ACID plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
T1/2
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
4 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11673644/ |
1400 mg single, oral dose: 1400 mg route of administration: Oral experiment type: SINGLE co-administered: |
FYTIC ACID plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
PubMed
| Title | Date | PubMed |
|---|---|---|
| A case of diaphragm hernia containing accessory spleen and great omentum detected by Tc-99m phytate scintigraphy. | 1999 Oct |
|
| Development, acceptability and nutritional evaluation of 'Doli Ki Roti'--an indigenously fermented bread. | 2001 |
|
| Absorption and excretion of orally administered inositol hexaphosphate (IP(6) or phytate) in humans. | 2001 |
|
| Soybeans and cancer prevention: a complex food and a complex disease. | 2001 |
|
| Rice-bran products: phytonutrients with potential applications in preventive and clinical medicine. | 2001 |
|
| Nutritional potential of biochemical components in Galactia longifolia Benth. (Fabaceae). | 2001 Apr |
|
| Rapid analysis of inositol phosphates. | 2001 Apr |
|
| Distal ligand reactivity and quaternary structure studies of proximally detached hemoglobins. | 2001 Apr 3 |
|
| Effect of soaking, germination, autoclaving and cooking on chemical and biological value of guar compared with faba bean. | 2001 Aug |
|
| A novel phytase with sequence similarity to purple acid phosphatases is expressed in cotyledons of germinating soybean seedlings. | 2001 Aug |
|
| Study on concretions developed around urinary catheters and mechanisms of renal calculi development. | 2001 Aug |
|
| GRAB: a physiologic guanine nucleotide exchange factor for Rab3A, which interacts with inositol hexakisphosphate kinase. | 2001 Aug 16 |
|
| Nutrient distribution and phenolic antioxidants in air-classified fractions of beach pea (Lathyrus maritimus L.). | 2001 Feb |
|
| Assessment of home-based processing methods to reduce the phytate content and phytate/zinc molar ratio of white maize (Zea mays). | 2001 Feb |
|
| Problems associated with measuring phytate in infant cereals. | 2001 Feb |
|
| Nutrient distribution and zinc bioavailability. Estimation in some tropical edible mushrooms. | 2001 Feb |
|
| Chemical composition and nutritional characteristics of some hull less and hulled barley cultivars grown in India. | 2001 Feb |
|
| Effect of myo-inositol(1,4,5)trisphosphate on the hydrolysis of phytic acid by phytase. | 2001 Feb-Apr |
|
| Iron absorption from experimental infant formulas based on pea (Pisum sativum)-protein isolate: the effect of phytic acid and ascorbic acid. | 2001 Jan |
|
| Inositol hexaphosphate inhibits ultraviolet B-induced signal transduction. | 2001 Jul |
|
| Nutritional composition of uncommon foods and their role in meeting micronutrient needs. | 2001 Jul |
|
| Effect of several germination conditions on total P, phytate P, phytase, and acid phosphatase activities and inositol phosphate esters in rye and barley. | 2001 Jul |
|
| G0/G1 arrest and S phase inhibition of human cancer cell lines by inositol hexaphosphate (IP6). | 2001 Jul-Aug |
|
| Proposed phytic acid standard including a method for its analysis. | 2001 Jul-Aug |
|
| Determination of phytic acid by gas chromatography-mass spectroscopy: application to biological samples. | 2001 Jun 15 |
|
| Beta 93 modified hemoglobin: kinetic and conformational consequences. | 2001 Jun 26 |
|
| Development and sensory evaluation of soy milk based yoghurt. | 2001 Mar |
|
| ATP production from adenine by a self-coupling enzymatic process: high-level accumulation under ammonium-limited conditions. | 2001 Mar |
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| Extracellular secretion of Aspergillus phytase from Arabidopsis roots enables plants to obtain phosphorus from phytate. | 2001 Mar |
|
| The use of near-infrared reflectance spectroscopy to predict the moisture, nitrogen, calcium, total phosphorus, gross energy, and phytate phosphorus contents of broiler excreta. | 2001 Mar |
|
| Inositol phosphates from barley low-phytate grain mutants analysed by metal-dye detection HPLC and NMR. | 2001 Mar 1 |
|
| Purification and properties of extracellular phytase from Bacillus sp. KHU-10. | 2001 May |
|
| Reduction by phytate-reduced soybean beta-conglycinin of plasma triglyceride level of young and adult rats. | 2001 May |
|
| Prolonged fermentation of whole wheat sourdough reduces phytate level and increases soluble magnesium. | 2001 May |
|
| Purification and characterization of a phytate-degrading enzyme from germinated faba beans (Vicia faba Var. Alameda). | 2001 May |
|
| Production, purification and properties of microbial phytases. | 2001 May |
|
| Oxidation of polyphenols in phytate-reduced high-tannin cereals: effect on different phenolic groups and on in vitro accessible iron. | 2001 Nov |
|
| Use of fungal phytase to improve breadmaking performance of whole wheat bread. | 2001 Nov |
|
| The use of 99mTc-phytate for sentinel node mapping in melanoma, breast cancer and vulvar cancer: a study of 100 cases. | 2001 Nov |
|
| Stereospecificity of myo-inositol hexakisphosphate dephosphorylation by a phytate-degrading enzyme of Escherichia coli. | 2001 Nov 17 |
|
| Effects of wheat maturation stage and cooking method on dietary fiber and phytic acid contents of firik, a wheat-based local food. | 2001 Oct |
|
| Can dietary treatment of non-anemic iron deficiency improve iron status? | 2001 Oct |
|
| Ingestion of insoluble dietary fibre increased zinc and iron absorption and restored growth rate and zinc absorption suppressed by dietary phytate in rats. | 2001 Oct |
|
| Seeds for a better future: 'low phytate' grains help to overcome malnutrition and reduce pollution. | 2001 Oct |
|
| Organic phosphates as a new class of soluble guanylate cyclase inhibitors. | 2001 Oct 19 |
|
| Enzyme mechanism and catalytic property of beta propeller phytase. | 2001 Sep |
|
| Calcium-binding capacities of different brans under simulated gastrointestinal pH conditions. In vitro study with (45)Ca. | 2001 Sep |
|
| Processing of newly released ricebean and fababean cultivars: changes in total and available calcium, iron and phosphorus. | 2001 Sep |
|
| [In vitro availability of minerals in infant foods with different protein source]. | 2001 Sep-Oct |
|
| Phytic Acid: From Antinutritional to Multiple Protection Factor of Organic Systems. | 2016 Jun |
Patents
Sample Use Guides
In MC65 cells, 48-72-hour treatment with phytic acid (100 uM) provided complete protection against amyloid precursor protein-C-terminal fragment-induced cytotoxicity by attenuating levels of increased intracellular calcium, hydrogen peroxide, superoxide, Aβ oligomers, and moderately upregulated the expression of autophagy (beclin-1) protein.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 17 20:26:39 UTC 2022
by
admin
on
Sat Dec 17 20:26:39 UTC 2022
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| Record UNII |
3F6PM8J684
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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C167212
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3F6PM8J684
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17211-15-3
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66391
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DTXSID00938091
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CHEMBL1233511
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ACTIVE MOIETY |