Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C6H6O24P6.9Na.3H |
| Molecular Weight | 857.8718 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 6 / 6 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H+].[H+].[H+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)O[C@@H]1[C@H](OP([O-])([O-])=O)[C@H](OP([O-])([O-])=O)[C@@H](OP([O-])([O-])=O)[C@H](OP([O-])([O-])=O)[C@H]1OP([O-])([O-])=O
InChI
InChIKey=FENRSEGZMITUEF-ATTCVCFYSA-E
InChI=1S/C6H18O24P6.9Na/c7-31(8,9)25-1-2(26-32(10,11)12)4(28-34(16,17)18)6(30-36(22,23)24)5(29-35(19,20)21)3(1)27-33(13,14)15;;;;;;;;;/h1-6H,(H2,7,8,9)(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)(H2,19,20,21)(H2,22,23,24);;;;;;;;;/q;9*+1/p-9/t1-,2-,3-,4+,5-,6-;;;;;;;;;
| Molecular Formula | H |
| Molecular Weight | 1.0079 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | Na |
| Molecular Weight | 22.9898 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C6H6O24P6 |
| Molecular Weight | 647.94 |
| Charge | -12 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 6 / 6 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
DescriptionCurator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/16401188 | https://www.ncbi.nlm.nih.gov/pubmed/28233043 | https://www.ncbi.nlm.nih.gov/pubmed/26859648 | https://www.ncbi.nlm.nih.gov/pubmed/20127021
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/16401188 | https://www.ncbi.nlm.nih.gov/pubmed/28233043 | https://www.ncbi.nlm.nih.gov/pubmed/26859648 | https://www.ncbi.nlm.nih.gov/pubmed/20127021
Phytate Sodium is a complex sodium salt of the corn-derived plant component Phytic Acid , that used as a chelating agent in all types of cosmetic products, including soaps, shampoos, balms and leave-on products for the face or body. Phytate Sodium is a biodegradable product and appears in the form of a dark-coloured liquid, is soluble in water and has a characteristic odour. It can be used in all types of cosmetic products, including soaps, shampoos, balms and leave-on products for the face or body. In vivo and in vitro experiments have demonstrated striking anticancer (preventive as well as therapeutic) effects of phytic acid. Research shows anti-carcinogenic effects, albeit to a lesser extent and it acts in inhibiting cancer. In addition to reduction in cell proliferation, phytic acid increases differentiation of malignant cells often resulting in reversion to the normal phenotype. Phytates participation in important intracellular biochemical pathways, normal physiological presence in human cells, tissues, plasma, urine, etc., the levels of which fluctuate with intake, epidemiological correlates of phytate deficiency with disease and reversal of those conditions by adequate intake, and safety – all strongly suggest for phytates inclusion as an essential nutrient, perhaps a vitamin. Phytic acid, mostly as Phytate Sodium or other phytates, is found within the hulls of nuts, seeds, and grains. No detectable phytate (less than 0.02 % of wet weight) was observed in vegetables such as scallion and cabbage leaves or in fruits such as apples, oranges, bananas, or pears. In-home food preparation techniques can break down the phytic acid in all of these foods. Simply cooking the food will reduce the phytic acid to some degree. More effective methods are soaking in an acid medium, sprouting and lactic acid fermentation such as in sourdough and pickling.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: GO:0034440 |
|||
Target ID: Metals (Iron, Zinc) |
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Target ID: AP2 complex |
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Target ID: CHEMBL2363056 |
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Target ID: CHEMBL2364030 |
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Target ID: GO:0055065 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Palliative | Unknown Approved UseUnknown |
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| Preventing | Unknown Approved UseUnknown |
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Sources: DOI: 10.1046/j.1365-2621.2002.00620.x |
Preventing | Unknown Approved UseUnknown |
||
| Primary | Unknown Approved UseUnknown |
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| Primary | Unknown Approved UseUnknown |
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| Primary | Unknown Approved UseUnknown |
|||
Sources: http://www.nutrientsreview.com/phytonutrients/phytic-acid-inositol-hexaphosphate.html https://www.accessdata.fda.gov/scripts/fdcc/index.cfm?set=grasnotices&id=381 https://naturellecosmetics.com/iblog/reasons-for-phytic-acid-use-in-natural-cosmetics http://www.biosiltech.com/pdf/Phytic%20Acid%20Extreme%20-%20Data%20Sheet%202017.pdf http://www.biosiltech.com/pdf/new_formula_sheets/Phytic%20Acid%20Resurfacing%20Toner%20PS1-301.pdf |
Primary | Unknown Approved UseUnknown |
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
0.12 μg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11673644/ |
1400 mg single, oral dose: 1400 mg route of administration: Oral experiment type: SINGLE co-administered: |
FYTIC ACID plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
AUC
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
0.52 μg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11673644/ |
1400 mg single, oral dose: 1400 mg route of administration: Oral experiment type: SINGLE co-administered: |
FYTIC ACID plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
T1/2
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
4 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11673644/ |
1400 mg single, oral dose: 1400 mg route of administration: Oral experiment type: SINGLE co-administered: |
FYTIC ACID plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Development, acceptability and nutritional evaluation of 'Doli Ki Roti'--an indigenously fermented bread. | 2001 |
|
| Soybeans and cancer prevention: a complex food and a complex disease. | 2001 |
|
| Effect of heat processing on in vitro protein digestibility and some chemical properties of African breadfruit (Treculia africana Decne) seeds. | 2001 |
|
| Rice-bran products: phytonutrients with potential applications in preventive and clinical medicine. | 2001 |
|
| Influence of inositolhexaphosphori acid (phytic acid) on the copper distribution in tissues and the excretion of copper in rats. | 2001 Apr |
|
| In vitro availability of zinc from infant foods with increasing phytic acid contents. | 2001 Aug |
|
| Pigs expressing salivary phytase produce low-phosphorus manure. | 2001 Aug |
|
| Study on concretions developed around urinary catheters and mechanisms of renal calculi development. | 2001 Aug |
|
| GRAB: a physiologic guanine nucleotide exchange factor for Rab3A, which interacts with inositol hexakisphosphate kinase. | 2001 Aug 16 |
|
| Assessment of home-based processing methods to reduce the phytate content and phytate/zinc molar ratio of white maize (Zea mays). | 2001 Feb |
|
| Problems associated with measuring phytate in infant cereals. | 2001 Feb |
|
| Nutrient distribution and zinc bioavailability. Estimation in some tropical edible mushrooms. | 2001 Feb |
|
| Chemical composition and nutritional characteristics of some hull less and hulled barley cultivars grown in India. | 2001 Feb |
|
| Nutritional composition of uncommon foods and their role in meeting micronutrient needs. | 2001 Jul |
|
| Effect of several germination conditions on total P, phytate P, phytase, and acid phosphatase activities and inositol phosphate esters in rye and barley. | 2001 Jul |
|
| G0/G1 arrest and S phase inhibition of human cancer cell lines by inositol hexaphosphate (IP6). | 2001 Jul-Aug |
|
| Accessory spleen in the pelvis diagnosed by Tc-99m phytate scintigraphy. | 2001 Jun |
|
| Beta 93 modified hemoglobin: kinetic and conformational consequences. | 2001 Jun 26 |
|
| The use of near-infrared reflectance spectroscopy to predict the moisture, nitrogen, calcium, total phosphorus, gross energy, and phytate phosphorus contents of broiler excreta. | 2001 Mar |
|
| Inositol phosphates from barley low-phytate grain mutants analysed by metal-dye detection HPLC and NMR. | 2001 Mar 1 |
|
| Direct observation of two distinct affinity conformations in the T state human deoxyhemoglobin. | 2001 Mar 9 |
|
| Purification and properties of extracellular phytase from Bacillus sp. KHU-10. | 2001 May |
|
| Reduction by phytate-reduced soybean beta-conglycinin of plasma triglyceride level of young and adult rats. | 2001 May |
|
| A physiological manoeuvre to improve the positivity of the gastro-oesophageal reflux scintigraphic test. | 2001 May |
|
| Purification and characterization of a phytate-degrading enzyme from germinated faba beans (Vicia faba Var. Alameda). | 2001 May |
|
| Transgenic mice expressing bacterial phytase as a model for phosphorus pollution control. | 2001 May |
|
| Oxidation of polyphenols in phytate-reduced high-tannin cereals: effect on different phenolic groups and on in vitro accessible iron. | 2001 Nov |
|
| Use of fungal phytase to improve breadmaking performance of whole wheat bread. | 2001 Nov |
|
| Stereospecificity of myo-inositol hexakisphosphate dephosphorylation by a phytate-degrading enzyme of Escherichia coli. | 2001 Nov 17 |
|
| High affinity association of myo-inositol trisphosphates with phytase and its effect upon the catalytic potential of the enzyme. | 2001 Nov 23 |
|
| Effects of wheat maturation stage and cooking method on dietary fiber and phytic acid contents of firik, a wheat-based local food. | 2001 Oct |
|
| Organic phosphates as a new class of soluble guanylate cyclase inhibitors. | 2001 Oct 19 |
|
| Probing the importance of the amino-terminal sequence of the beta- and gamma-chains to the properties of normal adult and fetal hemoglobins. | 2001 Oct 9 |
|
| Enzyme mechanism and catalytic property of beta propeller phytase. | 2001 Sep |
|
| Calcium-binding capacities of different brans under simulated gastrointestinal pH conditions. In vitro study with (45)Ca. | 2001 Sep |
|
| Effects of phytic acid and xanthotoxin on growth and detoxification in caterpillars. | 2001 Sep |
|
| [In vitro availability of minerals in infant foods with different protein source]. | 2001 Sep-Oct |
|
| Preparation of phytate-removed deamidated soybean globulins by ion exchangers and characterization of their calcium-binding ability. | 2002 Jan 2 |
|
| Phytic Acid: From Antinutritional to Multiple Protection Factor of Organic Systems. | 2016 Jun |
Patents
Sample Use Guides
In MC65 cells, 48-72-hour treatment with phytic acid (100 uM) provided complete protection against amyloid precursor protein-C-terminal fragment-induced cytotoxicity by attenuating levels of increased intracellular calcium, hydrogen peroxide, superoxide, Aβ oligomers, and moderately upregulated the expression of autophagy (beclin-1) protein.
| Substance Class |
Chemical
Created
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admin
on
Edited
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by
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on
Fri Dec 16 15:45:45 UTC 2022
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| Record UNII |
88496G1ERL
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| Record Status |
Validated (UNII)
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| Record Version |
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NCI_THESAURUS |
C360
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DTXSID60992770
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SUB15319MIG
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9903
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C87690
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88496G1ERL
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M8769
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7205-52-9
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88496G1ERL
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CHEMBL2005481
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| Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE |
