Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C21H29N7O14P2 |
Molecular Weight | 665.441 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 8 / 8 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
NC(=O)C1=CN(C=CC1)[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)N4C=NC5=C4N=CN=C5N)[C@@H](O)[C@H]2O
InChI
InChIKey=BOPGDPNILDQYTO-NNYOXOHSSA-N
InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1
Nicotinamide adenine nucleotide (NAD) is a cofactor found in all living cells. It exists in oxidized form (NAD+) and reduced form (NADH). NADH is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). NADH supplements are used for improving mental clarity, alertness, concentration, and memory; as well as for treating Alzheimer’s disease and dementia. Because of its role in energy production, NADH is also used for improving athletic performance and treating chronic fatigue syndrome (CFS). Some people use NADH for treating high blood pressure, high cholesterol, jet lag, depression, and Parkinson’s disease; opposing alcohol’s effects on the liver; reducing signs of aging; protecting against the side effects of an AIDS drug called zidovudine (AZT).
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL4506 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21528845 |
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Target ID: CHEMBL4835 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8308865 |
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Target ID: CHEMBL1970 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8308865 |
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PubMed
Title | Date | PubMed |
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RNA-stimulated NTPase activity associated with yellow fever virus NS3 protein expressed in bacteria. | 1993 Feb |
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Bcl-xL promotes the open configuration of the voltage-dependent anion channel and metabolite passage through the outer mitochondrial membrane. | 2001 Jun 1 |
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Mitochondrial NADH redox state, monitoring discovery and deployment in tissue. | 2004 |
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New photoproducts from irradiation of NADH with near-UV light. | 2004 Oct |
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Modulation of vascular reactivity in normal, hypertensive and diabetic rat aortae by a non-antioxidant flavonoid. | 2007 May |
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Structural and redox behavior of OxyVita, a zero-linked polymeric hemoglobin: comparison with natural acellular polymeric hemoglobins. | 2010 Apr |
Patents
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DSLD |
2235 (Number of products:5)
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DTXSID30889320
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4J24DQ0916
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16908
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57945
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439153
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NADH
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7222
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200-393-0
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m7699
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SUB33719
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100000127643
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DB00157
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58-68-4
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4J24DQ0916
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)