U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula Mg.O
Molecular Weight 40.3044
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Magnesium oxide

SMILES

[O--].[Mg++]

InChI

InChIKey=AXZKOIWUVFPNLO-UHFFFAOYSA-N
InChI=1S/Mg.O/q+2;-2

HIDE SMILES / InChI
Struvite, a crystalline substance first identified in the 18th century, is composed of magnesium ammonium phosphate. Struvite urinary stones are also known as ‘infection stones’, and account for 15%-20% of all urinary stones. Bacterial urease, usually from a Proteus species, is responsible for the chemical changes in urine which result in struvite formation.

Originator

Curator's Comment: Ulex, a Swedish geologist, is generally credited with introduction of the term struvite in1845

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Preventing
MAGNESIUM SULFATE

Approved Use

INDICATIONS AND USAGE Magnesium Sulfate in Water for Injection is indicated for the prevention and control of seizures in preeclampsia and eclampsia, respectively. When used judiciously it effectively prevents and controls the convulsions of eclampsia without producing deleterious depression of the central nervous system of the mother or infant. However, other effective drugs are available for this purpose.

Launch Date

1995
Primary
MAGNESIUM SULFATE

Approved Use

INDICATIONS AND USAGE Magnesium Sulfate in Water for Injection is indicated for the prevention and control of seizures in preeclampsia and eclampsia, respectively. When used judiciously it effectively prevents and controls the convulsions of eclampsia without producing deleterious depression of the central nervous system of the mother or infant. However, other effective drugs are available for this purpose.

Launch Date

1995
Diagnostic
ColPrep Kit

Approved Use

INDICATIONS AND USAGE ColPrep Kit is indicated for cleansing of the colon as a preparation for colonoscopy in adults

Launch Date

2016
Primary
MAGNESIUM SULFATE

Approved Use

INDICATIONS AND USAGE Magnesium Sulfate in Water for Injection is indicated for the prevention and control of seizures in preeclampsia and eclampsia, respectively. When used judiciously it effectively prevents and controls the convulsions of eclampsia without producing deleterious depression of the central nervous system of the mother or infant. However, other effective drugs are available for this purpose.

Launch Date

1995
Curative
MagMin

Approved Use

Magnesium aspartate (MagMin) is indicated for patients with documented hypomagnesaemia.
Curative
DELBIASE

Approved Use

Unknown
Primary
DELBIASE

Approved Use

Unknown
Primary
DELBIASE

Approved Use

Unknown
Curative
Magnesium Chloride

Approved Use

Magnesium Chloride injection is indicated as an electrolyte replenisher in magnesium deficiencies
Palliative
Magnesium Chloride

Approved Use

Unknown
Palliative
Magnesium Chloride

Approved Use

Unknown
Primary
EPIMAG

Approved Use

Magnesium citrate is indicated in cases of oxaluria, to prevent recurrence of calcium oxalate kidney stones.
Primary
EPIMAG

Approved Use

Used to relief of occasional constipation (irregularity).
Curative
Magnesium Citrate

Approved Use

Magnesium citrate is indicated to supports magnesium nutritional adequacy.
Curative
Unknown

Approved Use

Magnesium lactate is a naturally occurring mineral that is needed in the body to support the function of the heart, nervous system, and digestive system. Magnesium lactate is used as a mineral supplement to treat magnesium deficiency.
PubMed

PubMed

TitleDatePubMed
[Magnesium--an alternative in treatment resistant tachyarrhythmias].
1977 May 30
Serum calcium and magnesium levels in schizophrenia. II. Possible relationship to extrapyramidal symptoms.
1979 Nov
Characterization of the prolactin receptor in human prostate.
1983 Nov
Regulation of membrane histamine H1-receptor binding sites by guanine nucleotides, mono- and divalent cations.
1986 Apr
Metal: ATP characteristics of insulin- and epidermal growth factor-stimulated phosphorylation in detergent extracts of rat liver plasma membranes.
1986 Sep
Decreased intracellular free magnesium in erythrocytes of spontaneously hypertensive rats.
1987 Mar 30
Effect of magnesium diet in gentamicin-induced acute renal failure in rats.
1989
Polylysine specifically activates the insulin-dependent insulin receptor protein kinase.
1989 Jun 15
[Arrhythmogenic effect of flecainide--treatment with i.v. magnesium].
1989 Sep
Cocaine-induced cerebral vascular damage can be ameliorated by Mg2+ in rat brain.
1990 Feb 5
Magnesium inhibits the hypertensive but not the cardiotonic actions of low-dose epinephrine.
1991 Jun
Persistent paralysis in critically ill patients after long-term administration of vecuronium.
1992 Aug 20
['Cardiac ballet' with and without amiodarone].
1993 Jan 13
Cocaine-induced cerebrovasospasm and its possible mechanism of action.
1994 Mar
Differential modulation of alpha 3 beta 2 and alpha 3 beta 4 neuronal nicotinic receptors expressed in Xenopus oocytes by flufenamic acid and niflumic acid.
1995 Mar
Effects of felbamate on muscarinic and metabotropic-glutamate agonist-mediated responses and magnesium-free or 4-aminopyridine-induced epileptiform activity in guinea pig olfactory cortex neurons in vitro.
1996 Jun
Tissue and blood levels of zinc, copper, and magnesium in nitric oxide synthase blockade-induced hypertension.
2000 Nov
Evidence supporting a role for KCl cotransporter in the thick ascending limb of Henle's loop.
2001 Nov
Conversion of recent-onset atrial fibrillation or flutter with ibutilide after amiodarone has failed.
2002 Jul
Mechanisms of magnesium-stimulated adhesion of osteoblastic cells to commonly used orthopaedic implants.
2002 Nov
A preliminary, controlled investigation of magnesium L-aspartate hydrochloride for illicit cocaine and opiate use in methadone-maintained patients.
2003
Cell-associated magnesium and QT dispersion in hemodialysis patients.
2003 Jan
Interaction of Tl+ with product complexes of fructose-1,6-bisphosphatase.
2003 May 2
Elevated levels of ferrimagnetic metals in foodchains supporting the Guam cluster of neurodegeneration: do metal nucleated crystal contaminants [corrected] evoke magnetic fields that initiate the progressive pathogenesis of neurodegeneration?
2004
The effect of cations on the amidase activity of human tissue kallikrein: 1-linear competitive inhibition by sodium, potassium, calcium and magnesium. 2-linear mixed inhibition by aluminium.
2004 Aug
Ablation of calcitonin/calcitonin gene-related peptide-alpha impairs fetal magnesium but not calcium homeostasis.
2004 Aug
Use of ibutilide in cardioversion of patients with atrial fibrillation or atrial flutter treated with class IC agents.
2004 Aug 18
Magnesium influence on morphine--induced pharmacodependence in rats.
2004 Mar
A novel cation-sensing mechanism in osteoblasts is a molecular target for strontium.
2004 May
Conformational changes in sarcoplasmic reticulum Ca(2+)-ATPase mutants: effect of mutations either at Ca(2+)-binding site II or at tryptophan 552 in the cytosolic domain.
2006 Apr 25
Structure of pyrimidine 5'-nucleotidase type 1. Insight into mechanism of action and inhibition during lead poisoning.
2006 Jul 21
Activation and enzymatic characterization of recombinant human kallikrein 8.
2006 Jun
The expression of genes for transepithelial calcium-transporting proteins in the bovine duodenum.
2006 Mar
Kinetic properties of chimeric class I aldehyde dehydrogenases for retinal isomers.
2006 Oct
The specific, submicromolar-Km ADP-ribose pyrophosphatase purified from human placenta is enzymically indistinguishable from recombinant NUDT9 protein, including a selectivity for Mn2+ as activating cation and increase in Km for ADP-ribose, both elicited by H2O2.
2006 Oct
Divalent-metal-dependent nucleolytic activity of Cu, Zn superoxide dismutase.
2006 Oct
Cisplatin-induced hypomagnesemia and cardiac dysrhythmia.
2007 Nov
Characterization and distribution of the selected metals in the scalp hair of cancer patients in comparison with normal donors.
2007 Sep
The relation of magnesium and calcium intakes and a genetic polymorphism in the magnesium transporter to colorectal neoplasia risk.
2007 Sep
[The characterization of central neuromediation in rats fed with magnesium-deprived diet before and after magnesium replenishment].
2008 Jul
Inhibition of specific adenylyl cyclase isoforms by lithium and carbamazepine, but not valproate, may be related to their antidepressant effect.
2009 Dec
Magnesium modifies fentanyl-induced local antinociception and hyperalgesia.
2009 Nov
Evidence that TRPM7 is required for breast cancer cell proliferation.
2009 Sep
Hair tissue mineral analysis and metabolic syndrome.
2009 Sep
Differential effects of divalent manganese and magnesium on the kinase activity of leucine-rich repeat kinase 2 (LRRK2).
2010 Apr 13
Metals affect the structure and activity of human plasminogen activator inhibitor-1. II. Binding affinity and conformational changes.
2011 Feb
Millimolar Mn2+ influences agonist binding to 5-HT1A receptors by inhibiting guanosine nucleotide binding to receptor-coupled G-proteins.
2011 Jan
Mechanically enforced bond dissociation reports synergistic influence of Mn2+ and Mg2+ on the interaction between integrin α7β1 and invasin.
2011 Jul-Aug
Increased zinc and manganese in parallel with neurodegeneration, synaptic protein changes and activation of Akt/GSK3 signaling in ovine CLN6 neuronal ceroid lipofuscinosis.
2013
Ofloxacin induces apoptosis via β1 integrin-EGFR-Rac1-Nox2 pathway in microencapsulated chondrocytes.
2013 Feb 15
Patents

Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Rats: MgF2 dissolved in acetic acid (Mg=0.08 mM, F=0.084 mM) was delivered in the aerosol form https://www.ncbi.nlm.nih.gov/pubmed/20647692
Murine osteomyelitis model: medical pure titanium plates in size of 10 mm × 10 mm × 1 mm were used for the deposition of Magnesium Fluoride (MgF2) film.
Route of Administration: Topical
In Vitro Use Guide
Curator's Comment: Magnesium Chloride
Unknown
Name Type Language
Magnesium oxide
FCC   HSDB   II   INCI   MART.   MI   ORANGE BOOK   USP   VANDF   WHO-DD   WHO-IP  
INCI  
Official Name English
MAGNESIUM OXIDE, LIGHT [EP MONOGRAPH]
Common Name English
MAGNESIUM OXIDE, HEAVY [EP MONOGRAPH]
Common Name English
MAGNESIUM OXIDE, LIGHT
EP   II  
Common Name English
MAGNESIUM OXIDE [MI]
Common Name English
MAGNESIUM OXIDE [VANDF]
Common Name English
MAGNESIUM OXIDE [USP-RS]
Common Name English
MAGNESIUM OXIDE HEAVY [WHO-DD]
Common Name English
MAGNESIA [VANDF]
Common Name English
MAGNESIUM OXIDE [FCC]
Common Name English
MAGNESIUM OXIDE [MART.]
Common Name English
MAGNESIUM OXIDE [ORANGE BOOK]
Common Name English
MAGNESIA OXYDATA
HPUS  
Common Name English
MAGNESIUM OXIDE [JAN]
Common Name English
INS-530
Code English
INS NO.530
Code English
CLENPIQ COMPONENT MAGNESIUM OXIDE
Brand Name English
MAGNESIUM OXIDE, LIGHT [II]
Common Name English
MAGNESII OXIDUM [WHO-IP LATIN]
Common Name English
MAGNESIUM OXIDE [WHO-IP]
Common Name English
MAGNESIUM OXIDE, HEAVY
EP  
Common Name English
MAGNESIUM OXIDE [USP MONOGRAPH]
Common Name English
MAGNESIA OXYDATA [HPUS]
Common Name English
MAGNESIUM OXIDE [WHO-DD]
Common Name English
MAGNESIUM OXIDE COMPONENT OF CLENPIQ
Brand Name English
MAGNESIUM OXIDE [II]
Common Name English
LIGHT MAGNESIUM OXIDE [WHO-IP]
Common Name English
E-530
Code English
MAGNESIUM OXIDE, HEAVY [EP IMPURITY]
Common Name English
MAGNESIUM OXIDE [HSDB]
Common Name English
HEAVY MAGNESIUM OXIDE
WHO-IP  
Common Name English
MAGNESIUM OXIDE [INCI]
Common Name English
MAGNESIUM (AS OXIDE) [VANDF]
Common Name English
Classification Tree Code System Code
WHO-VATC QA02AA02
Created by admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
JECFA EVALUATION INS-530
Created by admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
CFR 21 CFR 331.15
Created by admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
WHO-ATC A12CC10
Created by admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
NCI_THESAURUS C29697
Created by admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
CODEX ALIMENTARIUS (GSFA) INS-530
Created by admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
WHO-VATC QA06AD02
Created by admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
CFR 21 CFR 331.11
Created by admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
WHO-ATC A02AA02
Created by admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
CFR 21 CFR 176.170
Created by admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
WHO-ATC A06AD02
Created by admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
CFR 21 CFR 184.1431
Created by admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
WHO-VATC QA12CC10
Created by admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
CFR 21 CFR 178.3297
Created by admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
Code System Code Type Description
EVMPD
SUB12130MIG
Created by admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
PRIMARY
CAS
1309-48-4
Created by admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
PRIMARY
DAILYMED
3A3U0GI71G
Created by admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
PRIMARY
MESH
D008277
Created by admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
PRIMARY
ECHA (EC/EINECS)
215-171-9
Created by admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
PRIMARY
NCI_THESAURUS
C29242
Created by admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
PRIMARY
RXCUI
6582
Created by admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
PRIMARY RxNorm
DRUG CENTRAL
4293
Created by admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
PRIMARY
HSDB
1652
Created by admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
PRIMARY
ChEMBL
CHEMBL1200572
Created by admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
PRIMARY
EVMPD
SUB14436MIG
Created by admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
PRIMARY
NCI_THESAURUS
C1505
Created by admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
CONCEPT Dietary Supplement
EVMPD
SUB12129MIG
Created by admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
PRIMARY
EPA CompTox
DTXSID9049665
Created by admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
PRIMARY
FDA UNII
3A3U0GI71G
Created by admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
PRIMARY
LACTMED
Magnesium Oxide
Created by admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
PRIMARY
SMS_ID
100000087594
Created by admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
MAGNESIUM OXIDE
Created by admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
PRIMARY Description: A white powder; odourless. Light Magnesium oxide is very bulky, whereas heavy Magnesium oxide is a dense powder. Solubility: Practically insoluble in water and ethanol (~750 g/l) TS; soluble in dilute acids. Category: Antacid. Storage: Magnesium oxide should be kept in a tightly closed container.Labelling: The designation on the container should state whether it is light Magnesium oxide or heavy Magnesium oxide.Definition: Magnesium oxide contains not less than 98.0% and not more than 100.5% of MgO, calculated with reference to the ignited substance.
WIKIPEDIA
MAGNESIUM OXIDE
Created by admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
PRIMARY
RS_ITEM_NUM
1374281
Created by admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
PRIMARY
CHEBI
31794
Created by admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
PRIMARY
DRUG BANK
DB01377
Created by admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
PRIMARY
PUBCHEM
6850729
Created by admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
PRIMARY
MERCK INDEX
m7011
Created by admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
PRIMARY Merck Index