Magnesium oxide

Details

Stereochemistry	ACHIRAL
Molecular Formula	Mg.O
Molecular Weight	40.3044
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

[O--].[Mg++]

InChI

InChIKey=AXZKOIWUVFPNLO-UHFFFAOYSA-N

InChI=1S/Mg.O/q+2;-2

HIDE SMILES / InChI

Description

Struvite, a crystalline substance first identified in the 18th century, is composed of magnesium ammonium phosphate. Struvite urinary stones are also known as ‘infection stones’, and account for 15%-20% of all urinary stones. Bacterial urease, usually from a Proteus species, is responsible for the chemical changes in urine which result in struvite formation.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
action potential 66	Inhibitor 8,297
magnesium ion homeostasis 70	Modulator 828
magnesium ion homeostasis 70	Modulator 828
oxalate metabolic process 66	Modulator 828
magnesium ion homeostasis 70	Modulator 828
magnesium ion homeostasis 70	Interacts 323
Protein S100-A8 66	Binding Agent 1,064

Conditions

Condition	Modality	Highest Phase	Product
Unknown 2,578
Unknown 2,578
Bone disease 70	Primary	Basic research	Unknown
Bacterial infections 234	Primary	Preclinical	Unknown
Bronchial spasm 78	Primary	Preclinical	Unknown
Unknown 2,578
Unknown 2,578
Unknown 2,578
Preeclampsia 85	Preventing	Approved 8,429	MAGNESIUM SULFATE
Eclampsia 69	Primary	Approved 8,429	MAGNESIUM SULFATE
Preparation for colonoscopy 66	Diagnostic	Approved 8,429	ColPrep Kit
Atrial fibrillation 131	Primary	Phase III 656	MAGNESIUM SULFATE
Unknown 2,578
Magnesium deficiency 67	Curative	Approved 8,429	MagMin
Unknown 2,578
Magnesium deficiency 67	Curative	Not Provided 504	DELBIASE
Eclampsia 69	Primary	Not Provided 504	DELBIASE
Convulsions 72	Primary	Not Provided 504	DELBIASE
Magnesium deficiency 67	Curative	Approved 8,429	Magnesium Chloride
Fibromyalgia 89	Palliative	Phase II 1,132	Magnesium Chloride
Stroke 144	Palliative	Phase III 656	Magnesium Chloride
Oxaluria 66	Primary	Approved 8,429	EPIMAG
Constipation 112	Primary	Approved 8,429	EPIMAG
Magnesium deficiency 67	Curative	Approved 8,429	Magnesium Citrate
Unknown 2,578
Magnesium deficiency 67	Curative	Approved 8,429	Unknown

PubMed

Show entries

Title	Date	PubMed
Effects of manganese, calcium, magnesium and lithium on the ouabain-induced seizure.	1977	608666
[Magnesium--an alternative in treatment resistant tachyarrhythmias].	1977 May 30	867390
Metal: ATP characteristics of insulin- and epidermal growth factor-stimulated phosphorylation in detergent extracts of rat liver plasma membranes.	1986 Sep	3527812
Decreased intracellular free magnesium in erythrocytes of spontaneously hypertensive rats.	1987 Mar 30	3566749
Characterization of the ATPase activity of the Mr 170,000 to 180,000 membrane glycoprotein (P-glycoprotein) associated with multidrug resistance in K562/ADM cells.	1988 Sep 1	2900677

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Patents

Sample Use Guides

In Vivo Use Guide

Murine osteomyelitis model: medical pure titanium plates in size of 10 mm × 10 mm × 1 mm were used for the deposition of Magnesium Fluoride (MgF2) film.

Route of Administration: Topical

In Vitro Use Guide

Unknown

Show entries

Name

Type

Language

Magnesium oxide

Official Name

English

MAGNESIUM OXIDE, LIGHT [EP MONOGRAPH]

Common Name