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Details

Stereochemistry
Molecular Formula 5CN.Fe.NO
Molecular Weight 215.9384
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge -2

SHOW SMILES / InChI
Structure of NITROPRUSSIDE

SMILES

[C-]#N.[C-]#N.[C-]#N.[C-]#N.[C-]#N.[Fe+2].N#[O+]

InChI

InChIKey=YEESUBCSWGVPCE-UHFFFAOYSA-N
InChI=1S/5CN.Fe.NO/c5*1-2;;1-2/q5*-1;+2;+1

HIDE SMILES / InChI
Nitroprusside is a medication which is used to lower blood pressure. It is comprised of a ferrous ion complexed with five cyanide and one nitrosyl group. Upon intravenous infusion, nitroprusside interacts with oxyhemoglobin and dissociates, releasing cyanide and nitric oxide, which act as a powerful vasodilating agent. Sodium nitroprusside was approved by the FDA in 1974 and is indicated for the immediate reduction of blood pressure of adult and pediatric patients in hypertensive crises. Sodium Nitroprusside injection is also indicated for producing controlled hypotension in order to reduce bleeding during surgery, and for the treatment of acute congestive heart failure.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
NIPRIDE

Approved Use

Sodium Nitroprusside injection is indicated for the immediate reduction of blood pressure of adult and pediatric patients in hypertensive crises. Concomitant longer-acting antihypertensive medication should be administered so that the duration of treatment with Sodium Nitroprusside can be minimized. Sodium Nitroprusside injection is also indicated for producing controlled hypotension in order to reduce bleeding during surgery. Sodium Nitroprusside injection is also indicated for the treatment of acute congestive heart failure.

Launch Date

1.50076801E11
Primary
NIPRIDE

Approved Use

Sodium Nitroprusside injection is indicated for the immediate reduction of blood pressure of adult and pediatric patients in hypertensive crises. Concomitant longer-acting antihypertensive medication should be administered so that the duration of treatment with Sodium Nitroprusside can be minimized. Sodium Nitroprusside injection is also indicated for producing controlled hypotension in order to reduce bleeding during surgery. Sodium Nitroprusside injection is also indicated for the treatment of acute congestive heart failure.

Launch Date

1.50076801E11
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
2 min
single, intravenous
NITROPRUSSIDE plasma
Rattus norvegicus
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer





Drug as perpetrator​
PubMed

PubMed

TitleDatePubMed
[The effects of sodiumnitroprusside and trimethaphan induced hypotension on haemodynamics and myocardial oxygen consumption (author's transl)].
1976 Jan
Venodilator effects of adenosine triphosphate and sodium nitroprusside; comparisons during controlled hypotension.
1987 Sep 1
Positive inotropy contributes to the hemodynamic mechanism of action of flosequinan (BTS 49465) in the intact dog.
1990 Jun
Rat renal papillary release of hypotensive substances in vitro.
1991 Aug
Effects of fenoldopam on renal blood flow and systemic hemodynamics during isoflurane anesthesia.
1991 Feb
ACTH and vasopressin responses to insulin-induced hypoglycemia in intact and neurohypophysectomized conscious dogs.
1991 Jan
Blood pressure, pulse, and neurohumoral responses to nitroprusside-induced hypotension in normotensive aging men.
1991 Jul
Comparative cardiovascular effects of SNP, ATP and phentolamine during norepinephrine-induced hypertension in dogs.
1991 Oct
Baroreflex changes produced by serotonergic or catecholaminergic lesions in the rat nucleus tractus solitarius.
1992 Apr
Esmolol infusion during nitroprusside-induced hypotension: impact on hemodynamics, ventricular performance, and venous admixture.
1992 Apr
Effect of hypotension and hyperosmolality on vasopressin and ACTH responses to hypoglycemia in conscious dogs.
1992 Aug
Bradykinin-induced activation of nociceptors: receptor and mechanistic studies on the neonatal rat spinal cord-tail preparation in vitro.
1992 Dec
Cardiovascular function during induced hypotension by fenoldopam or sodium nitroprusside in anesthetized dogs.
1992 Jan
Temporary blindness due to sodium nitroprusside overdosage in a postoperative patient: an unusual adverse effect.
1992 Jun
The ATP-sensitive K+ channel mediates hypotension in endotoxemia and hypoxic lactic acidosis in dog.
1992 Jun
Effect of N omega-nitro-L-arginine methyl ester on arterial pressure and on vasodilator and vasoconstrictor responses: influence of initial vascular tone.
1992 Mar 3
[Effects of deliberate hypotension on the ischemic heart during isoflurane anesthesia--a comparison of prostaglandin E1 and sodium nitroprusside].
1992 Sep
[The effects of sodium nitroprusside-induced hypotension at different levels on cerebral blood flow and metabolism: a clinical study].
2000 Aug
A-350619: a novel activator of soluble guanylyl cyclase.
2003 Jan 17
Sodium nitroprusside-induced deliberate hypotension to facilitate patent ductus arteriosus ligation in dogs.
2003 Jul-Aug
Cocaine- and amphetamine-regulated transcript is present in hypothalamic neuroendocrine neurones and is released to the hypothalamic-pituitary portal circuit.
2003 Mar
Hypothermia does not alter somatosensory evoked potential amplitude and global cerebral oxygen extraction during marked sodium nitroprusside-induced arterial hypotension.
2003 May
Zinc released from metallothionein-iii may contribute to hippocampal CA1 and thalamic neuronal death following acute brain injury.
2003 Nov
Receptor activity modifying protein 2 distribution in the rat central nervous system and regulation by changes in blood pressure.
2003 Sep
The role of endogenous heme synthesis and degradation domain cysteines in cellular iron-dependent degradation of IRP2.
2003 Sep-Oct
Esmolol attenuates hepatic blood flow responses during sodium nitroprusside-induced hypotension in dogs.
2004 Apr
Nitric oxide donor sodium nitroprusside dilates rat small arteries by activation of inward rectifier potassium channels.
2004 Apr
Additive antinociceptive effect of the combination of diazoxide, an activator of ATP-sensitive K+ channels, and sodium nitroprusside and dibutyryl-cGMP.
2004 Apr 5
Diminished baroreflex control of heart rate responses in otoconia-deficient C57BL/6JEi head tilt mice.
2004 Aug
Ferulic acid inhibits endothelial cell proliferation through NO down-regulating ERK1/2 pathway.
2004 Dec 15
Relationship between carbamoyl-phosphate synthetase genotype and systemic vascular function.
2004 Feb
Intrapericardial delivery enhances cardiac effects of sotalol and atenolol.
2004 Jul
Effects of TNF-alpha and IFN-gamma on nitric oxide-induced neurotoxicity in the mouse brain.
2004 Jun 1
Down-regulation of survivin in nitric oxide-induced cell growth inhibition and apoptosis of the human lung carcinoma cells.
2004 May 7
Regulation of cytoplasmic stress granules by apoptosis-inducing factor.
2004 Sep 1
Intracavernous sodium nitroprusside (SNP) versus papaverine/phentolamine in erectile dysfunction: a comparative study of short-term efficacy and side-effects.
2005 Jan
Dynamic beat-to-beat modeling of the QT-RR interval relationship: analysis of QT prolongation during alterations of autonomic state versus human ether a-go-go-related gene inhibition.
2005 Jan
Effects of sodium nitroprusside, a nitric oxide donor, on gamma-aminobutyric acid concentration in the brain and on picrotoxin-induced convulsions in combination with phenobarbitone in rats.
2005 Mar
Effect of nitric oxide on mitochondrial respiratory activity of human articular chondrocytes.
2005 Mar
Involvement of nitric oxide pathways in short term modulation of tyrosine hydroxylase activity by endothelins 1 and 3 in the rat anterior hypothalamus.
2005 Sep 2
Effect of nitric oxide on mitogen-activated protein kinases in neonatal pulmonary vascular smooth muscle.
2005 Sep-Oct
Hypoxia-mimetic agents desferrioxamine and cobalt chloride induce leukemic cell apoptosis through different hypoxia-inducible factor-1alpha independent mechanisms.
2006 Jan
Labetalol pretreatment reduces blood pressure instability during surgical resection of pheochromocytoma.
2006 Mar
Iron released by sodium nitroprusside contributes to heme oxygenase-1 induction via the cAMP-protein kinase A-mitogen-activated protein kinase pathway in RAW 264.7 cells.
2006 May
The cGMP/protein kinase G pathway contributes to dihydropyridine-sensitive calcium response and cytokine production in TH2 lymphocytes.
2006 May 5
Inhibitors of inducible nitric oxide (NO) synthase are more effective than an NO donor in reducing carbon-tetrachloride induced acute liver injury.
2006 Nov
S-nitrosylation of Bcl-2 inhibits its ubiquitin-proteasomal degradation. A novel antiapoptotic mechanism that suppresses apoptosis.
2006 Nov 10
Acrylamide analog as a novel nitric oxide-independent soluble guanylyl cyclase activator.
2006 Oct
Phenotype-dependent susceptibility of cholinergic neuroblastoma cells to neurotoxic inputs.
2006 Sep
Melittin inhibits inflammatory target gene expression and mediator generation via interaction with IkappaB kinase.
2007 Jan 15
Name Type Language
NITROPRUSSIDE
WHO-DD  
Common Name English
FERRATE(2-), PENTAKIS(CYANO-C)NITROSYL-, (OC-6-22)-
Common Name English
NITROPRUSSIDE [WHO-DD]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29707
Created by admin on Fri Jun 25 20:38:44 UTC 2021 , Edited by admin on Fri Jun 25 20:38:44 UTC 2021
LIVERTOX 692
Created by admin on Fri Jun 25 20:38:44 UTC 2021 , Edited by admin on Fri Jun 25 20:38:44 UTC 2021
NCI_THESAURUS C1937
Created by admin on Fri Jun 25 20:38:44 UTC 2021 , Edited by admin on Fri Jun 25 20:38:44 UTC 2021
FDA ORPHAN DRUG 112498
Created by admin on Fri Jun 25 20:38:44 UTC 2021 , Edited by admin on Fri Jun 25 20:38:44 UTC 2021
WHO-ATC C02DD01
Created by admin on Fri Jun 25 20:38:44 UTC 2021 , Edited by admin on Fri Jun 25 20:38:44 UTC 2021
WHO-VATC QC02DD01
Created by admin on Fri Jun 25 20:38:44 UTC 2021 , Edited by admin on Fri Jun 25 20:38:44 UTC 2021
NDF-RT N0000175940
Created by admin on Fri Jun 25 20:38:44 UTC 2021 , Edited by admin on Fri Jun 25 20:38:44 UTC 2021
Code System Code Type Description
WIKIPEDIA
Nitroprusside
Created by admin on Fri Jun 25 20:38:44 UTC 2021 , Edited by admin on Fri Jun 25 20:38:44 UTC 2021
PRIMARY
DRUG BANK
DB00325
Created by admin on Fri Jun 25 20:38:44 UTC 2021 , Edited by admin on Fri Jun 25 20:38:44 UTC 2021
PRIMARY
DRUG CENTRAL
4631
Created by admin on Fri Jun 25 20:38:44 UTC 2021 , Edited by admin on Fri Jun 25 20:38:44 UTC 2021
PRIMARY
LACTMED
Nitroprusside
Created by admin on Fri Jun 25 20:38:44 UTC 2021 , Edited by admin on Fri Jun 25 20:38:44 UTC 2021
PRIMARY
FDA UNII
169D1260KM
Created by admin on Fri Jun 25 20:38:44 UTC 2021 , Edited by admin on Fri Jun 25 20:38:44 UTC 2021
PRIMARY
PUBCHEM
124081848
Created by admin on Fri Jun 25 20:38:44 UTC 2021 , Edited by admin on Fri Jun 25 20:38:44 UTC 2021
PRIMARY
MESH
D009599
Created by admin on Fri Jun 25 20:38:44 UTC 2021 , Edited by admin on Fri Jun 25 20:38:44 UTC 2021
PRIMARY
EPA CompTox
15078-28-1
Created by admin on Fri Jun 25 20:38:44 UTC 2021 , Edited by admin on Fri Jun 25 20:38:44 UTC 2021
PRIMARY
RXCUI
7476
Created by admin on Fri Jun 25 20:38:44 UTC 2021 , Edited by admin on Fri Jun 25 20:38:44 UTC 2021
PRIMARY RxNorm
EVMPD
SUB14660MIG
Created by admin on Fri Jun 25 20:38:44 UTC 2021 , Edited by admin on Fri Jun 25 20:38:44 UTC 2021
PRIMARY
CAS
15078-28-1
Created by admin on Fri Jun 25 20:38:44 UTC 2021 , Edited by admin on Fri Jun 25 20:38:44 UTC 2021
PRIMARY
NCI_THESAURUS
C77153
Created by admin on Fri Jun 25 20:38:44 UTC 2021 , Edited by admin on Fri Jun 25 20:38:44 UTC 2021
PRIMARY