Details
Stereochemistry | ACHIRAL |
Molecular Formula | 2Cl.Mg.6H2O |
Molecular Weight | 203.303 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
O.O.O.O.O.O.[Mg++].[Cl-].[Cl-]
InChI
InChIKey=DHRRIBDTHFBPNG-UHFFFAOYSA-L
InChI=1S/2ClH.Mg.6H2O/h2*1H;;6*1H2/q;;+2;;;;;;/p-2
DescriptionSources: http://www.internationalcrystal.net/optics_11.htm | https://www.ncbi.nlm.nih.gov/pubmed/27792982 | https://www.ncbi.nlm.nih.gov/pubmed/26952467 | https://www.ncbi.nlm.nih.gov/pubmed/27995243https://www.scbt.com/scbt/product/magnesium-nitrate-hexahydrate-13446-18-9 | https://www.ncbi.nlm.nih.gov/pubmed/18964415 | https://www.ncbi.nlm.nih.gov/pubmed/2843308http://www.db-pharma.com/anglais/49.pdfhttp://www.sciencedirect.com/science/article/pii/004484868990080Xhttps://www.accessdata.fda.gov/drugsatfda_docs/label/2013/020309s028lbl.pdfhttps://hazmap.nlm.nih.gov/category-details?table=copytblagents&id=1640DOI: 10.2903/j.efsa.2008.883http://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2013.3444/pdfdoi: 10.1081/SCC-120022479https://www.xymogen.com/assets/imageDisplay.ashx?productID=111&attachmentTypeID=1https://www.drugs.com/ppa/magnesium-chloride.htmlhttps://www.ncbi.nlm.nih.gov/pubmed/15480451 | https://www.scbt.com/scbt/product/magnesium-iodide-10377-58-9https://www.drugs.com/dosage/magnesium-lactate.htmlhttp://dx.doi.org/10.1155/2015/498932 | http://iicbe.org/upload/4152C514072.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/351265Curator's Comment: Description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/9873215 | http://discovery.ucl.ac.uk/1336882/1/1336882.pdf
Sources: http://www.internationalcrystal.net/optics_11.htm | https://www.ncbi.nlm.nih.gov/pubmed/27792982 | https://www.ncbi.nlm.nih.gov/pubmed/26952467 | https://www.ncbi.nlm.nih.gov/pubmed/27995243https://www.scbt.com/scbt/product/magnesium-nitrate-hexahydrate-13446-18-9 | https://www.ncbi.nlm.nih.gov/pubmed/18964415 | https://www.ncbi.nlm.nih.gov/pubmed/2843308http://www.db-pharma.com/anglais/49.pdfhttp://www.sciencedirect.com/science/article/pii/004484868990080Xhttps://www.accessdata.fda.gov/drugsatfda_docs/label/2013/020309s028lbl.pdfhttps://hazmap.nlm.nih.gov/category-details?table=copytblagents&id=1640DOI: 10.2903/j.efsa.2008.883http://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2013.3444/pdfdoi: 10.1081/SCC-120022479https://www.xymogen.com/assets/imageDisplay.ashx?productID=111&attachmentTypeID=1https://www.drugs.com/ppa/magnesium-chloride.htmlhttps://www.ncbi.nlm.nih.gov/pubmed/15480451 | https://www.scbt.com/scbt/product/magnesium-iodide-10377-58-9https://www.drugs.com/dosage/magnesium-lactate.htmlhttp://dx.doi.org/10.1155/2015/498932 | http://iicbe.org/upload/4152C514072.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/351265
Curator's Comment: Description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/9873215 | http://discovery.ucl.ac.uk/1336882/1/1336882.pdf
Struvite, a crystalline substance first identified in the 18th century, is composed of magnesium ammonium
phosphate. Struvite urinary stones are also known as ‘infection stones’, and account for 15%-20% of all urinary stones. Bacterial urease, usually from a Proteus species, is responsible for the chemical changes in urine which result in struvite formation.
CNS Activity
Sources: DOI: 10.1002/0471238961.0218151310010311.a02Vink, R., Mihai Nechifor, M. (2011) 'Magnesium in the Central Nervous System', p.139 Retrieved from https://books.google.ru/books?id=GW0oExaZ7hQChttps://www.drugs.com/mtm/magnesium-lactate.html | https://www.ncbi.nlm.nih.gov/pubmed/27792736 | https://www.ncbi.nlm.nih.gov/pubmed/7669506
Curator's Comment: Magnesium Chloride
Originator
Sources: https://www.ncbi.nlm.nih.gov/pubmed/351265
Curator's Comment: Ulex, a Swedish geologist, is generally credited with introduction of the term struvite in1845
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: GO:0001508 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12225296 |
|||
Target ID: GO:0010960 |
|||
Target ID: GO:0033609 |
|||
Target ID: GO:0010960 |
|||
Target ID: P05109 Gene ID: 6279.0 Gene Symbol: S100A8 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/8061680 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
|||
Primary | Unknown Approved UseUnknown |
|||
Primary | Unknown Approved UseUnknown |
|||
Preventing | MAGNESIUM SULFATE Approved UseINDICATIONS AND USAGE
Magnesium Sulfate in Water for Injection is indicated for the prevention and control of seizures in preeclampsia and eclampsia, respectively. When used judiciously it effectively prevents and controls the convulsions of eclampsia without producing deleterious depression of the central nervous system of the mother or infant. However, other effective drugs are available for this purpose. Launch Date1995 |
|||
Primary | MAGNESIUM SULFATE Approved UseINDICATIONS AND USAGE
Magnesium Sulfate in Water for Injection is indicated for the prevention and control of seizures in preeclampsia and eclampsia, respectively. When used judiciously it effectively prevents and controls the convulsions of eclampsia without producing deleterious depression of the central nervous system of the mother or infant. However, other effective drugs are available for this purpose. Launch Date1995 |
|||
Diagnostic | ColPrep Kit Approved UseINDICATIONS AND USAGE
ColPrep Kit is indicated for cleansing of the colon as a preparation for colonoscopy in adults Launch Date2016 |
|||
Primary | MAGNESIUM SULFATE Approved UseINDICATIONS AND USAGE
Magnesium Sulfate in Water for Injection is indicated for the prevention and control of seizures in preeclampsia and eclampsia, respectively. When used judiciously it effectively prevents and controls the convulsions of eclampsia without producing deleterious depression of the central nervous system of the mother or infant. However, other effective drugs are available for this purpose. Launch Date1995 |
|||
Curative | MagMin Approved UseMagnesium aspartate (MagMin) is indicated for patients with documented hypomagnesaemia. |
|||
Curative | DELBIASE Approved UseUnknown |
|||
Primary | DELBIASE Approved UseUnknown |
|||
Primary | DELBIASE Approved UseUnknown |
|||
Curative | Magnesium Chloride Approved UseMagnesium Chloride injection is indicated as an electrolyte replenisher in magnesium deficiencies |
|||
Palliative | Magnesium Chloride Approved UseUnknown |
|||
Palliative | Magnesium Chloride Approved UseUnknown |
|||
Primary | EPIMAG Approved UseMagnesium citrate is indicated in cases of oxaluria, to prevent recurrence of calcium oxalate kidney stones. |
|||
Primary | EPIMAG Approved UseUsed to relief of occasional constipation (irregularity). |
|||
Curative | Magnesium Citrate Approved UseMagnesium citrate is indicated to supports magnesium nutritional adequacy. |
|||
Curative | Unknown Approved UseMagnesium lactate is a naturally occurring mineral that is needed in the body to support the function of the heart, nervous system, and digestive system. Magnesium lactate is used as a mineral supplement to treat magnesium deficiency. |
PubMed
Title | Date | PubMed |
---|---|---|
Effects of manganese, calcium, magnesium and lithium on the ouabain-induced seizure. | 1977 |
|
Evidence for separate peptide sequences related to the lipolytic and magnesium-accumulating activities of ACTH. Analogy with adrenergic receptors. | 1977 Apr |
|
[Magnesium--an alternative in treatment resistant tachyarrhythmias]. | 1977 May 30 |
|
Serum calcium and magnesium levels in schizophrenia. II. Possible relationship to extrapyramidal symptoms. | 1979 Nov |
|
Characterization of the prolactin receptor in human prostate. | 1983 Nov |
|
Symptomatic hypercalcaemia precipitated by magnesium therapy. | 1985 Jan |
|
Regulation of membrane histamine H1-receptor binding sites by guanine nucleotides, mono- and divalent cations. | 1986 Apr |
|
Metal: ATP characteristics of insulin- and epidermal growth factor-stimulated phosphorylation in detergent extracts of rat liver plasma membranes. | 1986 Sep |
|
Decreased intracellular free magnesium in erythrocytes of spontaneously hypertensive rats. | 1987 Mar 30 |
|
Characterization of the ATPase activity of the Mr 170,000 to 180,000 membrane glycoprotein (P-glycoprotein) associated with multidrug resistance in K562/ADM cells. | 1988 Sep 1 |
|
Effect of magnesium diet in gentamicin-induced acute renal failure in rats. | 1989 |
|
Polylysine specifically activates the insulin-dependent insulin receptor protein kinase. | 1989 Jun 15 |
|
[Arrhythmogenic effect of flecainide--treatment with i.v. magnesium]. | 1989 Sep |
|
Cocaine-induced cerebral vascular damage can be ameliorated by Mg2+ in rat brain. | 1990 Feb 5 |
|
Role of magnesium in cardiac tachyarrhythmias. | 1990 Jun 19 |
|
Modulation of mu, delta and kappa opioid receptors in rat brain by metal ions and histidine. | 1990 May |
|
Magnesium inhibits the hypertensive but not the cardiotonic actions of low-dose epinephrine. | 1991 Jun |
|
['Cardiac ballet' with and without amiodarone]. | 1993 Jan 13 |
|
Overexpressed protein kinase C-delta and -epsilon subtypes in NIH 3T3 cells exhibit differential subcellular localization and differential regulation of sodium-dependent phosphate uptake. | 1994 Feb 18 |
|
Cocaine-induced cerebrovasospasm and its possible mechanism of action. | 1994 Mar |
|
Differential modulation of alpha 3 beta 2 and alpha 3 beta 4 neuronal nicotinic receptors expressed in Xenopus oocytes by flufenamic acid and niflumic acid. | 1995 Mar |
|
Effects of felbamate on muscarinic and metabotropic-glutamate agonist-mediated responses and magnesium-free or 4-aminopyridine-induced epileptiform activity in guinea pig olfactory cortex neurons in vitro. | 1996 Jun |
|
Characterization and distribution of the selected metals in the scalp hair of cancer patients in comparison with normal donors. | 2007 Sep |
|
[The characterization of central neuromediation in rats fed with magnesium-deprived diet before and after magnesium replenishment]. | 2008 Jul |
|
Interactions between magnesium and psychotropic drugs. | 2008 Jun |
|
Treatment of migraine with prophylactic drugs. | 2008 Oct |
|
Cocaine use disorders and serum magnesium profile. | 2009 |
|
Inhibition of specific adenylyl cyclase isoforms by lithium and carbamazepine, but not valproate, may be related to their antidepressant effect. | 2009 Dec |
|
Differential binding of inorganic particles to MARCO. | 2009 Jan |
|
AZT-induced oxidative cardiovascular toxicity: attenuation by Mg-supplementation. | 2009 Jun |
|
The loop connecting metal-binding domains 3 and 4 of ATP7B is a target of a kinase-mediated phosphorylation. | 2009 Jun 23 |
|
Magnesium modifies fentanyl-induced local antinociception and hyperalgesia. | 2009 Nov |
|
Evidence that TRPM7 is required for breast cancer cell proliferation. | 2009 Sep |
|
Hair tissue mineral analysis and metabolic syndrome. | 2009 Sep |
|
Differential effects of divalent manganese and magnesium on the kinase activity of leucine-rich repeat kinase 2 (LRRK2). | 2010 Apr 13 |
|
Involvement of transient receptor potential melastatin-related 7 (TRPM7) channels in cadmium uptake and cytotoxicity in MC3T3-E1 osteoblasts. | 2010 Dec 15 |
|
Carcinogenic heavy metals replace Ca2+ for DNA binding and annealing activities of mono-ubiquitinated annexin A1 homodimer. | 2010 Oct 1 |
|
Metals affect the structure and activity of human plasminogen activator inhibitor-1. II. Binding affinity and conformational changes. | 2011 Feb |
|
Metals affect the structure and activity of human plasminogen activator inhibitor-1. I. Modulation of stability and protease inhibition. | 2011 Feb |
|
Millimolar Mn2+ influences agonist binding to 5-HT1A receptors by inhibiting guanosine nucleotide binding to receptor-coupled G-proteins. | 2011 Jan |
|
Mechanically enforced bond dissociation reports synergistic influence of Mn2+ and Mg2+ on the interaction between integrin α7β1 and invasin. | 2011 Jul-Aug |
|
Hypoxia induces an increase in intracellular magnesium via transient receptor potential melastatin 7 (TRPM7) channels in rat hippocampal neurons in vitro. | 2011 Jun 10 |
|
NADH fluorescence lifetime analysis of the effect of magnesium ions on ALDH2. | 2011 May 30 |
|
Increased zinc and manganese in parallel with neurodegeneration, synaptic protein changes and activation of Akt/GSK3 signaling in ovine CLN6 neuronal ceroid lipofuscinosis. | 2013 |
|
Warfarin accelerates ectopic mineralization in Abcc6(-/-) mice: clinical relevance to pseudoxanthoma elasticum. | 2013 Apr |
|
Ofloxacin induces apoptosis via β1 integrin-EGFR-Rac1-Nox2 pathway in microencapsulated chondrocytes. | 2013 Feb 15 |
|
Fluorescence lifetime analysis and effect of magnesium ions on binding of NADH to human aldehyde dehydrogenase 1. | 2013 Feb 25 |
|
Catalytic contribution of threonine 244 in human ALDH2. | 2013 Feb 25 |
|
Altered biometal homeostasis is associated with CLN6 mRNA loss in mouse neuronal ceroid lipofuscinosis. | 2013 Jun 15 |
|
Assessment of infantile mineral imbalances in autism spectrum disorders (ASDs). | 2013 Nov 11 |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/27995243
Curator's Comment: Rats: MgF2 dissolved in acetic acid (Mg=0.08 mM, F=0.084 mM) was delivered in the aerosol form
https://www.ncbi.nlm.nih.gov/pubmed/20647692
Murine osteomyelitis model: medical pure titanium plates in size of 10 mm × 10 mm × 1 mm
were used for the deposition of Magnesium Fluoride (MgF2) film.
Route of Administration:
Topical
Name | Type | Language | ||
---|---|---|---|---|
|
Official Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
WHO-VATC |
QB05XA11
Created by
admin on Fri Dec 15 15:49:19 GMT 2023 , Edited by admin on Fri Dec 15 15:49:19 GMT 2023
|
||
|
EPA PESTICIDE CODE |
13902
Created by
admin on Fri Dec 15 15:49:19 GMT 2023 , Edited by admin on Fri Dec 15 15:49:19 GMT 2023
|
||
|
WHO-ATC |
B05XA11
Created by
admin on Fri Dec 15 15:49:19 GMT 2023 , Edited by admin on Fri Dec 15 15:49:19 GMT 2023
|
||
|
WHO-ATC |
A12CC01
Created by
admin on Fri Dec 15 15:49:19 GMT 2023 , Edited by admin on Fri Dec 15 15:49:19 GMT 2023
|
||
|
CODEX ALIMENTARIUS (GSFA) |
INS-511
Created by
admin on Fri Dec 15 15:49:19 GMT 2023 , Edited by admin on Fri Dec 15 15:49:19 GMT 2023
|
||
|
JECFA EVALUATION |
INS-511
Created by
admin on Fri Dec 15 15:49:19 GMT 2023 , Edited by admin on Fri Dec 15 15:49:19 GMT 2023
|
||
|
CFR |
21 CFR 184.1426
Created by
admin on Fri Dec 15 15:49:19 GMT 2023 , Edited by admin on Fri Dec 15 15:49:19 GMT 2023
|
||
|
WHO-VATC |
QA12CC01
Created by
admin on Fri Dec 15 15:49:19 GMT 2023 , Edited by admin on Fri Dec 15 15:49:19 GMT 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
DB09407
Created by
admin on Fri Dec 15 15:49:19 GMT 2023 , Edited by admin on Fri Dec 15 15:49:19 GMT 2023
|
PRIMARY | |||
|
SUB12526MIG
Created by
admin on Fri Dec 15 15:49:19 GMT 2023 , Edited by admin on Fri Dec 15 15:49:19 GMT 2023
|
PRIMARY | |||
|
m6996
Created by
admin on Fri Dec 15 15:49:19 GMT 2023 , Edited by admin on Fri Dec 15 15:49:19 GMT 2023
|
PRIMARY | Merck Index | ||
|
6636
Created by
admin on Fri Dec 15 15:49:19 GMT 2023 , Edited by admin on Fri Dec 15 15:49:19 GMT 2023
|
PRIMARY | |||
|
CHEMBL2219642
Created by
admin on Fri Dec 15 15:49:19 GMT 2023 , Edited by admin on Fri Dec 15 15:49:19 GMT 2023
|
PRIMARY | |||
|
7791-18-6
Created by
admin on Fri Dec 15 15:49:19 GMT 2023 , Edited by admin on Fri Dec 15 15:49:19 GMT 2023
|
PRIMARY | |||
|
221118
Created by
admin on Fri Dec 15 15:49:19 GMT 2023 , Edited by admin on Fri Dec 15 15:49:19 GMT 2023
|
PRIMARY | |||
|
13778-96-6
Created by
admin on Fri Dec 15 15:49:19 GMT 2023 , Edited by admin on Fri Dec 15 15:49:19 GMT 2023
|
ALTERNATIVE | |||
|
02F3473H9O
Created by
admin on Fri Dec 15 15:49:19 GMT 2023 , Edited by admin on Fri Dec 15 15:49:19 GMT 2023
|
PRIMARY | |||
|
C29240
Created by
admin on Fri Dec 15 15:49:19 GMT 2023 , Edited by admin on Fri Dec 15 15:49:19 GMT 2023
|
PRIMARY | |||
|
100000091409
Created by
admin on Fri Dec 15 15:49:19 GMT 2023 , Edited by admin on Fri Dec 15 15:49:19 GMT 2023
|
PRIMARY | |||
|
02F3473H9O
Created by
admin on Fri Dec 15 15:49:19 GMT 2023 , Edited by admin on Fri Dec 15 15:49:19 GMT 2023
|
PRIMARY | |||
|
4200
Created by
admin on Fri Dec 15 15:49:19 GMT 2023 , Edited by admin on Fri Dec 15 15:49:19 GMT 2023
|
PRIMARY | |||
|
SUB50141
Created by
admin on Fri Dec 15 15:49:19 GMT 2023 , Edited by admin on Fri Dec 15 15:49:19 GMT 2023
|
PRIMARY | |||
|
24644
Created by
admin on Fri Dec 15 15:49:19 GMT 2023 , Edited by admin on Fri Dec 15 15:49:19 GMT 2023
|
PRIMARY | |||
|
6579
Created by
admin on Fri Dec 15 15:49:19 GMT 2023 , Edited by admin on Fri Dec 15 15:49:19 GMT 2023
|
ALTERNATIVE | |||
|
1374248
Created by
admin on Fri Dec 15 15:49:19 GMT 2023 , Edited by admin on Fri Dec 15 15:49:19 GMT 2023
|
PRIMARY | |||
|
C1505
Created by
admin on Fri Dec 15 15:49:19 GMT 2023 , Edited by admin on Fri Dec 15 15:49:19 GMT 2023
|
CONCEPT | Dietary Supplement | ||
|
D015636
Created by
admin on Fri Dec 15 15:49:19 GMT 2023 , Edited by admin on Fri Dec 15 15:49:19 GMT 2023
|
PRIMARY | |||
|
DTXSID0020789
Created by
admin on Fri Dec 15 15:49:19 GMT 2023 , Edited by admin on Fri Dec 15 15:49:19 GMT 2023
|
PRIMARY | |||
|
86345
Created by
admin on Fri Dec 15 15:49:19 GMT 2023 , Edited by admin on Fri Dec 15 15:49:19 GMT 2023
|
PRIMARY | |||
|
SUB20644
Created by
admin on Fri Dec 15 15:49:19 GMT 2023 , Edited by admin on Fri Dec 15 15:49:19 GMT 2023
|
PRIMARY | |||
|
MAGNESIUM CHLORIDE
Created by
admin on Fri Dec 15 15:49:19 GMT 2023 , Edited by admin on Fri Dec 15 15:49:19 GMT 2023
|
PRIMARY |
ACTIVE MOIETY
SUBSTANCE RECORD