Inxight Drugs

Search results for "SUBCHAPTER E--ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS" in comments (approximate match)

Showing 1 - 10 of 291 results

Posaconazole

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6TK1G07BHZ

Status:

US Approved Rx (2023)

First approved in 2006

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Conditions:

Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. It marketed in the United States, the European Union, and in other countries by Sc...

TINIDAZOLE

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033KF7V46H

Status:

US Approved Rx (2004)

First approved in 2004

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Conditions:

Tinidazole is a synthetic antiprotozoal agent, formally known as 1-[2-(ethylsulfonyl)ethyl]-2-methyl-5-nitroimidazole and a second-generation 2-methyl-5-nitroimidazole. Tinidazole is a prodrug and antiprotozoal agent. The nitro group of tinidazole is...

MELOXICAM

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VG2QF83CGL

Status:

US Approved Rx (2006)

First approved in 2000

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Conditions:

Meloxicam (brand name Mobic) is an nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Mobic is indicated for the relief of the signs and symptoms of osteoarthritis and rheumatoid arthritis, and has been available i...

CEFPODOXIME

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7R4F94TVGY

Status:

US Approved Rx (2007)

First approved in 1992

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Conditions:

Cefpodoxime is an orally administered, extended spectrum, semi-synthetic antibiotic of the cephalosporin class. Cefpodoxime is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. Cefpodoxime has activity in the presence of ...

PACLITAXEL

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P88XT4IS4D

Status:

US Approved Rx (2005)

First approved in 1992

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Conditions:

Paclitaxel is a mitotic inhibitor used in cancer chemotherapy. It was discovered in a US National Cancer Institute program at the Research Triangle Institute in 1967 when Monroe E. Wall and Mansukh C. Wani isolated it from the bark of the Pacific yew...

tree, Taxus brevifolia and named it taxol. Later it was discovered that endophytic fungi in the bark synthesize paclitaxel. When it was developed commercially by Bristol-Myers Squibb (BMS), the generic name was changed to paclitaxel and the BMS compound is sold under the trademark Taxol. In this formulation, paclitaxel is dissolved in Kolliphor EL and ethanol, as a delivery agent. Taxol is marketed for the treatment of Breast cancer; Gastric cancer; Kaposi's sarcoma; Non-small cell lung cancer; Ovarian cancer. A newer formulation, in which paclitaxel is bound to albumin, is sold under the trademark Abraxane. Paclitaxel is a taxoid antineoplastic agent indicated as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary, and other various cancers including breast cancer. Paclitaxel is a novel antimicrotubule agent that promotes the assembly of microtubules from tubulin dimers and stabilizes microtubules by preventing depolymerization. This stability results in the inhibition of the normal dynamic reorganization of the microtubule network that is essential for vital interphase and mitotic cellular functions. In addition, paclitaxel induces abnormal arrays or "bundles" of microtubules throughout the cell cycle and multiple asters of microtubules during mitosis. Used in the treatment of Kaposi's sarcoma and cancer of the lung, ovarian, and breast. Abraxane® is specfically indicated for the treatment of metastatic breast cancer and locally advanced or metastatic non-small cell lung cancer. Paclitaxel interferes with the normal function of microtubule growth. Whereas drugs like colchicine cause the depolymerization of microtubules in vivo, paclitaxel arrests their function by having the opposite effect; it hyper-stabilizes their structure. This destroys the cell's ability to use its cytoskeleton in a flexible manner. Specifically, paclitaxel binds to the β subunit of tubulin. Tubulin is the "building block" of mictotubules, and the binding of paclitaxel locks these building blocks in place. The resulting microtubule/paclitaxel complex does not have the ability to disassemble. This adversely affects cell function because the shortening and lengthening of microtubules (termed dynamic instability) is necessary for their function as a transportation highway for the cell. Chromosomes, for example, rely upon this property of microtubules during mitosis. Further research has indicated that paclitaxel induces programmed cell death (apoptosis) in cancer cells by binding to an apoptosis stopping protein called Bcl-2 (B-cell leukemia 2) and thus arresting its function.

TERBINAFINE

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G7RIW8S0XP

Status:

US Approved Rx (2007)

First approved in 1992

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Conditions:

Terbinafine (brand name Lamisil, Terbisil, Terboderm and others) is an antifungal medication used to treat ringworm and fungal nail infections. Terbinafine inhibits ergosterol synthesis by inhibiting squalene epoxidase, an enzyme that is part of the...

ETODOLAC

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2M36281008

Status:

US Approved Rx (2020)

First approved in 1991

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

Conditions:

Etodolac is an anti-inflammatory agent with analgesic and antipyretic properties. It is used to treat osteoarthritis, rheumatoid arthritis and control acute pain. The therapeutic effects of etodolac are achieved via inhibition of the synthesis of pro...

ALBENDAZOLE

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F4216019LN

Status:

US Approved Rx (2019)

First approved in 1989

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Conditions:

ALBENZA (albendazole) is an orally administered anthelmintic drug. Chemically, it is methyl 5¬ (propylthio)-2-benzimidazolecarbamate, is indicated to treatment of parenchymal neurocysticercosis due to active lesions caused by larval forms of the pork...

CLOMIPRAMINE

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NUV44L116D

Status:

US Approved Rx (2020)

First approved in 1989

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Conditions:

Clomipramine is an antidepressant drug which was approved by FDA for the treatment of Obsessive-Compulsive Disorder. The exact mechanism of its action is unknown, however it is supposed that it may exert its effect by inhibiting serotonin reuptake.

DICLOFENAC

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144O8QL0L1

Status:

US Approved Rx (2020)

First approved in 1988

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Conditions:

Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) of the phenylacetic acid class with anti-inflammatory, analgesic, and antipyretic properties. Contrary to the action of many traditional NSAIDs, diclofenac inhibits cyclooxygenase (COX)-2 en...

zyme with greater potency than it does COX-1. In addition diclofenac can inhibit the thromboxane-prostanoid receptor, affect arachidonic acid release and uptake, inhibit lipoxygenase enzymes, and activate the nitric oxide-cGMP antinociceptive pathway. Other novel mechanisms of action may include the inhibition of substrate P, inhibition of peroxisome proliferator activated receptor gamma (PPARgamma), blockage of acid-sensing ion channels, alteration of interleukin-6 production, and inhibition of N-methyl-D-aspartate (NMDA) receptor hyperalgesia. Similar to other NSAIDs, diclofenac is associated with serious dose-dependent gastrointestinal, cardiovascular, and renal adverse effects. Since its introduction in 1973, a number of different diclofenac-containing drug products have been developed with the goal of improving efficacy, tolerability, and patient convenience. Delayed- and extended-release forms of diclofenac sodium were initially developed with the goal of improving the safety profile of diclofenac and providing convenient, once-daily dosing for the treatment of patients with chronic pain. New drug products consisting of diclofenac potassium salt were associated with faster absorption and rapid onset of pain relief. These include diclofenac potassium immediate-release tablets, diclofenac potassium liquid-filled soft gel capsules, and diclofenac potassium powder for oral solution. The advent of topical formulations of diclofenac enabled local treatment of pain and inflammation while minimizing systemic absorption of diclofenac. SoluMatrix diclofenac, consisting of submicron particles of diclofenac free acid and a proprietary combination of excipients, was developed to provide analgesic efficacy at reduced doses associated with lower systemic absorption. The drug's likely impact on the Asian vulture population was widely reported. The dramatic mortality was attributed largely to renal failure caused by exposure to diclofenac in livestock carcasses on which the birds fed. Although not the most endearing species, vultures are important environmental scavengers and, since veterinary use of diclofenac was stopped in the region in 2006, the decline in vulture numbers has slowed.

Development Status

Primary Target

Highest Phase

Approval Year

Condition

Treatment Modality

CNS Activity

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ATC Level 1

ATC Level 2

ATC Level 3

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Substance Form

Search results for "SUBCHAPTER E--ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS" in comments (approximate match)

Posaconazole

6TK1G07BHZ

TINIDAZOLE

033KF7V46H

MELOXICAM

VG2QF83CGL

CEFPODOXIME

7R4F94TVGY

PACLITAXEL

P88XT4IS4D

TERBINAFINE

G7RIW8S0XP

ETODOLAC

2M36281008

ALBENDAZOLE

F4216019LN

CLOMIPRAMINE

NUV44L116D

DICLOFENAC

144O8QL0L1