8-oxyberberine (8-Oxoberberine, JKL1073A), an oxoderivative of berberine, is an alkaloid isolated from Argemone mexicana. 8-oxyberberine has been initially reported to exert anti-proliferative effects against a series of cancers. 8-oxyberberine inhibited the cell proliferation in human colon cancer cells. 8-Oxoberberine, a derivative of berberine, has been reported to exert antiarrhythmic activity, much like a class III antiarrhythmic agent. 8-Oxoberberine, like berberine, exerted positive inotropic and negative chronotropic actions. In rat left atria 8-oxoberberine, 10 to 100 uM, increased atrial contractility. In spontaneously beating right atria, 8-oxoberberine increased atrial contractility but slightly decreased the rate of contractions. 8-Oxoberberine inhibited the integral of the transient outward current (Ito) with a KD value of approximately 4 uM in either human or rat atrial myocytes. 8-Oxoberberine inhibited Ito by binding to open-state channels or by shifting the steady state inactivation curve of Ito.

The triterpene chikusetsusaponin IVa, also called, as Chikusetsu saponin Iva and CALENDULOSIDE F, was isolated from the fruit of Ilex paraguariensis. Using animal model it was shown that this compound could be a promising novel therapeutic agent for diabetic cardiomyopathy, due to its cardio protection; this effect can be reached by activation of the SIRT1/ERK1/2/Homer1a pathway. In addition was demonstrated, that chikusetsusaponin IVa exerts antithrombotic effects, including minor hemorrhagic events, by inhibition of thrombin in a competitive manner.

Isocorydine is a member of the class of compounds known as aporphines. Isocorydine is practically insoluble in water and weakly acidic. It is a naturally occurring plant metabolite which can be found in cherimoya and poppy. Isocorydine has generated interest as a potential anti-cancer compound for its ability to induce G2/M cell cycle arrest and apoptosis.