Haloxon is an organophosphorus anthelmintic once used against nematodes of the abomasum and small intestine in ruminants. Haloxon is an organophosphorus cholinesterase antagonist. Laboratory and field trials with 7-day-old, 14-day-old and adult infections of the common gastrointestinal nematodes in 600 sheep showed that Haloxon at a dose rate of 30 to 55 mg. per kg. body-weight was a very highly efficient anthelrnintic. The drug was particularly effective against all stages of Haemonchus contenus, Trichostrongylus spp. and Coopería curticei; it was more active against adult than against larval Ostertagia spp" and Nematodirus spp. High activity was also reported against Strongyloides papillosus, Bunostomum trigono-cephalum and Oesophagostomum venulosumum but not against Trichuris avis nor Chabertia ovina.

CLOMACRAN, a non-phenothiazine tricyclic compound, is an antipsychotic drug.

Clorfenvinfos (chlorfenvinphos) is an organophosphate insecticide, which is used to control insect pests on livestock, and to control household pests such as flies, fleas, and mites. Clorfenvinfos was sold under trade names including Birlane®, Dermaton®, Sapercon®, Steladone®, and Supona®. In 1991 all products containing clorfenvinfos were banned in the USA. Toxicity of clorfenvinfos is due to inhibition of acetylcholinesterase. Inhibition of cholinesterase activity results in the accumulation of acetylcholine at muscarinic and nicotinic receptors. This leads to continuous or excessive stimulation of cholinergic fibers in the post-ganglionic parasympathetic nerve endings, neuromuscular junctions of the skeletal muscles, resulting in hyperpolarization of nerve or muscle fibers and receptor desensitization until hydrolysis of the phosphorylated cholinesterase occurs. In some cases, a dealkylation and stabilization of the phosphorylated enzyme (“aging”) occur such that hydrolysis can no longer take place and the enzyme is irreversibly inhibited. In such cases, the return of acetylcholinesterase activity parallels the time required to resynthesize this enzyme.