U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C14H14Cl3O6P
Molecular Weight 415.59
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of HALOXON

SMILES

CC1=C(Cl)C(=O)OC2=CC(OP(=O)(OCCCl)OCCCl)=CC=C12

InChI

InChIKey=KULDXINYXFTXMO-UHFFFAOYSA-N
InChI=1S/C14H14Cl3O6P/c1-9-11-3-2-10(8-12(11)22-14(18)13(9)17)23-24(19,20-6-4-15)21-7-5-16/h2-3,8H,4-7H2,1H3

HIDE SMILES / InChI

Molecular Formula C14H14Cl3O6P
Molecular Weight 415.59
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Haloxon is an organophosphorus anthelmintic once used against nematodes of the abomasum and small intestine in ruminants. Haloxon is an organophosphorus cholinesterase antagonist. Laboratory and field trials with 7-day-old, 14-day-old and adult infections of the common gastrointestinal nematodes in 600 sheep showed that Haloxon at a dose rate of 30 to 55 mg. per kg. body-weight was a very highly efficient anthelrnintic. The drug was particularly effective against all stages of Haemonchus contenus, Trichostrongylus spp. and Coopería curticei; it was more active against adult than against larval Ostertagia spp" and Nematodirus spp. High activity was also reported against Strongyloides papillosus, Bunostomum trigono-cephalum and Oesophagostomum venulosumum but not against Trichuris avis nor Chabertia ovina.

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Haloxon drench

PubMed

Sample Use Guides

In Vivo Use Guide
Horses: The recommended dose of the drug is 60 mg/kg. Haloxon is a safe drug producing no ill effects even upto 3 times the therapeutic dose.
Route of Administration: Oral
In Vitro Use Guide
H. gallinae was killed by 10(-4) M haloxon
Substance Class Chemical
Record UNII
T8KXA37068
Record Status Validated (UNII)
Record Version