Details
Stereochemistry | ACHIRAL |
Molecular Formula | C14H14Cl3O6P |
Molecular Weight | 415.59 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=C(Cl)C(=O)OC2=CC(OP(=O)(OCCCl)OCCCl)=CC=C12
InChI
InChIKey=KULDXINYXFTXMO-UHFFFAOYSA-N
InChI=1S/C14H14Cl3O6P/c1-9-11-3-2-10(8-12(11)22-14(18)13(9)17)23-24(19,20-6-4-15)21-7-5-16/h2-3,8H,4-7H2,1H3
Haloxon is an organophosphorus anthelmintic once used against nematodes of the abomasum and small intestine in ruminants. Haloxon is an organophosphorus cholinesterase antagonist. Laboratory and field trials with 7-day-old, 14-day-old and adult infections of the common gastrointestinal nematodes in 600 sheep showed that Haloxon at a dose rate of 30 to 55 mg. per kg. body-weight was a very highly efficient anthelrnintic. The drug was particularly effective against all stages of Haemonchus contenus, Trichostrongylus spp. and Coopería curticei; it was more active against adult than against larval Ostertagia spp" and Nematodirus spp. High activity was also reported against Strongyloides papillosus, Bunostomum trigono-cephalum and Oesophagostomum venulosumum but not against Trichuris avis nor Chabertia ovina.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL220 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Curative | Haloxon drench Approved UseFor control of gastrointestinal roundworms of the genera Haemonchus, Ostertagia,Trichostrongylus, and Cooperia in cattle. |
PubMed
Title | Date | PubMed |
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The influence of peripheral site ligands on the reaction of symmetric and chiral organophosphates with wildtype and mutant acetylcholinesterases. | 1999 May 14 |
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Peripheral site ligands accelerate inhibition of acetylcholinesterase by neutral organophosphates. | 2001 Dec |
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Structure-inhibition relationships in the interaction of butyrylcholinesterase with bambuterol, haloxon and their leaving groups. | 2005 Dec 15 |
Patents
Sample Use Guides
Horses: The recommended dose of the drug is 60 mg/kg. Haloxon is a safe drug producing no ill effects even upto 3 times the therapeutic dose.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3777528
H. gallinae was killed by 10(-4) M haloxon
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Classification Tree | Code System | Code | ||
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CFR |
21 CFR 520.1120
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CFR |
21 CFR 556.310
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CFR |
21 CFR 520.1120A
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WHO-VATC |
QP52AB04
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CFR |
21 CFR 520.1120B
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NCI_THESAURUS |
C250
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321-55-1
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m1185
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206-289-1
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C75220
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DB11419
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CHEMBL1897362
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2041
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Haloxon
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T8KXA37068
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100000083927
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9454
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SUB08011MIG
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C007902
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DTXSID5046221
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ACTIVE MOIETY