Cliprofen is a non-steroidal anti-inflammatory drug.

Metiprenaline was developed as a bronchodilator. Information about the current use of this compound is not available.

Pirdonium is an antihistamine agent. It is the hydrophilic Histamine H1 receptor antagonist.

GALARUBICIN (DA-125) is an anthracycline derivative with anticancer activity, containing fluorine. The mechanism of action of this drug lies in inhibition of nucleic acid synthesis through intercalation with DNA. Because the structure and DNA-intercalating properties of DA-125 are similar to adriamycin, the cytotoxic effects of the two anthracyclines probably have similar biochemical mechanisms. Preclinical studies suggest that it may have greater activity and less cardiac toxicity than adriamycin. In a rodent study, administration of D-125 in higher dose levels (25 to 50 mg/kg) has been shown to result in testicular damage.

Brovanexine is a derivative of bromhexine used as an adjunct to antibacterials in preparations for the treatment of respiratory-tract infections. Oral administration of brovanexine hydrochloride (BR-222) caused a significant increase in the output volume of respiratory tract fluid. Brovanexine at 10 and 20 mg/kg showed a tendency to reduce the viscosity of respiratory tract fluid in anesthetized dogs. Brovanexine also showed a tendency to reduce the viscosity of sputum obtained from the SO2-exposed rabbits.

Cismadinone is a progestogen steroid.

Cistinexine is an expectorant drug developed by Italian company Recordati S.p.A. Cistinexine as a cystine derivative that has shown an expectorant action similar to bromhexine during preclinical pharmacological trials. In clinical trials in patients with chronic bronchitis, treatment with cistinexine did not lead to a reduction of mucus transport rate (MTR). The only significant effect was observed in patients with severe impairment of MTR.

FEPENTOLIC ACID is a choleretic agent.

FENPIPRAMIDE is a parasympatholytic agent. As a hydrochloride salt, it is an active ingredient of some veterinary medicinal products used as analgesic drugs or antidotes. FENPIPRAMIDE was formerly used in humans as a spasmolytic in obstetrics.

Etanterol (VAL 481), a phenethanolamine derivative, is a β2 adrenoceptor agonist that was undergoing phase II trials in Italy as a bronchodilator with Valeas.