Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C30H32FNO13 |
| Molecular Weight | 633.5724 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 7 / 7 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]5(O[C@H]1C[C@@](O)(CC2=C(O)C3=C(C(=O)C4=C(OC)C=CC=C4C3=O)C(O)=C12)C(=O)COC(=O)CCN)O[C@@H](C)[C@@H](O)[C@@H](O)[C@H]5F
InChI
InChIKey=CKXIPXAIFMTQCS-LRDUUELOSA-N
InChI=1S/C30H32FNO13/c1-11-23(35)28(40)22(31)29(44-11)45-15-9-30(41,16(33)10-43-17(34)6-7-32)8-13-19(15)27(39)21-20(25(13)37)24(36)12-4-3-5-14(42-2)18(12)26(21)38/h3-5,11,15,22-23,28-29,35,37,39-41H,6-10,32H2,1-2H3/t11-,15-,22+,23+,28-,29-,30-/m0/s1
GALARUBICIN (DA-125) is an anthracycline derivative with anticancer activity, containing fluorine. The mechanism of action of this drug lies in inhibition of nucleic acid synthesis through intercalation with DNA. Because the structure and DNA-intercalating properties of DA-125 are similar to adriamycin, the cytotoxic effects of the two anthracyclines probably have similar biochemical mechanisms. Preclinical studies suggest that it may have greater activity and less cardiac toxicity than adriamycin. In a rodent study, administration of D-125 in higher dose levels (25 to 50 mg/kg) has been shown to result in testicular damage.
Approval Year
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NCI_THESAURUS |
C1594
Created by
admin on Fri Dec 15 16:02:34 GMT 2023 , Edited by admin on Fri Dec 15 16:02:34 GMT 2023
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| Code System | Code | Type | Description | ||
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C81422
Created by
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6F39648E92
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100000087256
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CHEMBL2106451
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7826
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SUB02302MIG
Created by
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195612-80-7
Created by
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114759
Created by
admin on Fri Dec 15 16:02:34 GMT 2023 , Edited by admin on Fri Dec 15 16:02:34 GMT 2023
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PRIMARY |
ACTIVE MOIETY
SALT/SOLVATE (PARENT)
