BROVANEXINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H28Br2N2O4
Molecular Weight	568.298
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC(=CC=C1OC(C)=O)C(=O)NC2=C(CN(C)C3CCCCC3)C=C(Br)C=C2Br

InChI

InChIKey=DQTRREPKGJIABH-UHFFFAOYSA-N

InChI=1S/C24H28Br2N2O4/c1-15(29)32-21-10-9-16(12-22(21)31-3)24(30)27-23-17(11-18(25)13-20(23)26)14-28(2)19-7-5-4-6-8-19/h9-13,19H,4-8,14H2,1-3H3,(H,27,30)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6489870 | https://www.ncbi.nlm.nih.gov/pubmed/6745807 | https://www.ncbi.nlm.nih.gov/pubmed/2824118

Brovanexine is a derivative of bromhexine used as an adjunct to antibacterials in preparations for the treatment of respiratory-tract infections. Oral administration of brovanexine hydrochloride (BR-222) caused a significant increase in the output volume of respiratory tract fluid. Brovanexine at 10 and 20 mg/kg showed a tendency to reduce the viscosity of respiratory tract fluid in anesthetized dogs. Brovanexine also showed a tendency to reduce the viscosity of sputum obtained from the SO2-exposed rabbits.

Originator

Approval Year

PubMed

Title	Date	PubMed
Molecular nature of three liver alkaline phosphatases detected by drug administration in vivo: differences between soluble and membranous enzymes.	1987	2824118

Patents

Sample Use Guides

In Vivo Use Guide

Brovanexine (50 mg/kg, orally) increased secretion of nasal mucus in rabbits.

Route of Administration: Oral

Name

Type

Language

BROVANEXINE

Official Name

English

BRONQUIMUCIL

Preferred Name

English

brovanexine [INN]

Common Name

English

Brovanexine [WHO-DD]

Common Name

English

2',4'-DIBROMO-.ALPHA.-(CYCLOHEXYLMETHYLAMINO)-O-VANILLOTOLUIDIDE ACETATE (ESTER)

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C74536