BROVANEXINE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H28Br2N2O4.ClH
Molecular Weight	604.759
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.COC1=CC(=CC=C1OC(C)=O)C(=O)NC2=C(CN(C)C3CCCCC3)C=C(Br)C=C2Br

InChI

InChIKey=GOPILTWRTSSNPV-UHFFFAOYSA-N

InChI=1S/C24H28Br2N2O4.ClH/c1-15(29)32-21-10-9-16(12-22(21)31-3)24(30)27-23-17(11-18(25)13-20(23)26)14-28(2)19-7-5-4-6-8-19;/h9-13,19H,4-8,14H2,1-3H3,(H,27,30);1H

HIDE SMILES / InChI

Molecular Formula	C24H28Br2N2O4
Molecular Weight	568.298
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6489870 | https://www.ncbi.nlm.nih.gov/pubmed/6745807 | https://www.ncbi.nlm.nih.gov/pubmed/2824118

Brovanexine is a derivative of bromhexine used as an adjunct to antibacterials in preparations for the treatment of respiratory-tract infections. Oral administration of brovanexine hydrochloride (BR-222) caused a significant increase in the output volume of respiratory tract fluid. Brovanexine at 10 and 20 mg/kg showed a tendency to reduce the viscosity of respiratory tract fluid in anesthetized dogs. Brovanexine also showed a tendency to reduce the viscosity of sputum obtained from the SO2-exposed rabbits.

Originator

Approval Year

PubMed

Title	Date	PubMed
Molecular nature of three liver alkaline phosphatases detected by drug administration in vivo: differences between soluble and membranous enzymes.	1987	2824118

Patents

Sample Use Guides

In Vivo Use Guide

Brovanexine (50 mg/kg, orally) increased secretion of nasal mucus in rabbits.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:53:18 GMT 2023` Edited by `admin` on `Fri Dec 15 16:53:18 GMT 2023`
Record UNII	51I4IS0SMG
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BROVANEXINE HYDROCHLORIDE

Common Name

English

BR-222

Code

English

4-(ACETYLOXY)-N-(2,4-DIBROMO-6-((CYCLOHEXYLMETHYLAMINO)METHYL)PHENYL)-3-METHOXYBENZAMIDE MONOHYDROCHLORIDE

Systematic Name

English

UR-389

Code

English

BR 222

Code

English

BROVANEXINE HCL

Common Name

English

Brovanexine hydrochloride [WHO-DD]

Common Name

English

BROVANEXINE HYDROCHLORIDE [MART.]

Common Name

English

BENZAMIDE, 4-(ACETYLOXY)-N-(2,4-DIBROMO-6-((CYCLOHEXYLMETHYLAMINO)METHYL)PHENYL)-3-METHOXY-, HYDROCHLORIDE (1:1)

Systematic Name

English

UR 389

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C74536