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Restrict the search for
methyl salicylate
to a specific field?
Class (Stereo):
CHEMICAL (RACEMIC)
Tiquinamide (Wy 24081) is a potent inhibitor of gastric secretion and gives good protection in animals against gastric and duodenal erosions induced by stress and chemical stimuli. It reduces basal as well as stimulated acid secretion but has no anticholinergic activity and is only a weak histamine H2 antagonist, since it is substantially more potent in inhibiting basal acid-secretion than the established H2-receptor antagonists, metiamide and burimamide. Since no other pharmacological effect of tiquinamide has been detected in isolated tissues, it seems unlikely that the gastric antisecretory effect of the compound results from a direct action on the peripheral autonomic nervous system. The report from Dr. Szabo on the protective effect of dopamine agonists against duodenal ulceration suggests a possible mechanism of action for tiquinamide.
Status:
Investigational
Class (Stereo):
CHEMICAL (ACHIRAL)
Mecrylate (metyl 2-cyanoacrylate) ) is a clear,
colorless liquid with a strong, acrid odor. In contact with hydroxide ions (liquids like blood or water, air humidity), the cyanoacrylates form long, strong and waterproof chains in an exothermic reaction. The resulting polymer leads to a stable adhesive bond. It may be used as tissue adhesive in surgery. Mecrylate is the first generation short-chain cyanoacrylate, it turned out to be histotoxic and caused distinct foreign-body reactions.
Status:
Investigational
Source:
NCT00742716: Phase 2 Interventional Completed Chronic Kidney Disease
(2008)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Lunacalcipol (CTA-018 or MT-2832) is a vitamin D analog having a dual mechanism of action. It inhibits CYP24A1 and induced VDR expression. It was being developed for the treatment of clinical consequences of vitamin D insufficiency and secondary hyperparathyroidism associated with chronic kidney disease. Lunacalcipol development has been discontinued.
Class (Stereo):
CHEMICAL (RACEMIC)
Moxnidazole is an antiparasitic drug suitable for oral use against parasites in farm animals. administration of Moxnidazole in the drinking water gave good prophylaxis of dysentery in swine, histomoniasis in hens and turkeys, and trichomoniasis in pigeons. Isolated relapses were due to renfections and were successfully treated by another dose of the drug.
Status:
Investigational
Source:
NCT03175497: Phase 1 Interventional Completed Solid Tumor, Adult
(2017)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Telatinib (Bay-579352) developed by Bayer is an orally available and highly potent inhibitor of tyrosine kinases VEGFR2,VEGFR3, PDGFR and c-Kit. Telatinib is a potent inhibitor of angiogenesis. Telatinib caused a significant decrease in endothelium-dependent and endothelium-independent vasodilation. Telatinib demonstrates anti-tumor activity in various cancer models. Telatinib is ready for phase III clinical trials for the treatment of gastric cancer. In 2010, it has been granted orphan drug status by the FDA. Most frequent adverse events were pain, nausea, voice changes and fatigue.
Status:
Investigational
Source:
INN:sulfonterol [INN]
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Sulfonterol is a benzenemethanol derivative patented by Smith Kline and French Laboratories as a bronchodilator. Sulfonterol acts as a β-adrenergic partial agonist.
Status:
Investigational
Source:
INN:pararosaniline embonate [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Pararosaniline pamoate (CI 403-A) was developed as an orally active drug for the treatment of Schistosoma japonicum infection. The clinical trial has shown that capsules were safe and effective; in addition, this drug was well tolerated with a minimum of side effects, which were mostly mild and transient and did not require interruption of treatment. Besides, pararosaniline pamoate was an inhibitor of E.histolytica Hsp90 (EhHsp90) with promising activity against the parasite Pararosaniline pamoate, that causes amebiasis worldwide. Information about the current use of this drug is not available.
Class (Stereo):
CHEMICAL (UNKNOWN)
Furcloprofen was developed as an analgesic agent with anti-inflammatory properties. Information about the current use of this compound is not available.
Status:
Investigational
Class (Stereo):
CHEMICAL (ACHIRAL)
Esculamine is a hemostatic, vasodilator and anti-inflammatory agent.
Status:
Investigational
Source:
INN:balamapimod [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Balamapimod, also known as MKI 833, a mitogen-activated protein kinase (Ras/Raf/MEK) inhibitor with potential anti-tumor activity. This compound can be used for the treatment of diseases that are results of deregulation of Ras/Raf/MEK kinases.
