Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C23H16O6.2C19H17N3 |
| Molecular Weight | 963.0863 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NC1=CC=C(C=C1)C(C2=CC=C(N)C=C2)=C3C=CC(=N)C=C3.NC4=CC=C(C=C4)C(C5=CC=C(N)C=C5)=C6C=CC(=N)C=C6.OC(=O)C7=CC8=C(C=CC=C8)C(CC9=C%10C=CC=CC%10=CC(C(O)=O)=C9O)=C7O
InChI
InChIKey=CEYTZVVSYBTFCX-UHFFFAOYSA-N
InChI=1S/C23H16O6.2C19H17N3/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29;2*20-16-7-1-13(2-8-16)19(14-3-9-17(21)10-4-14)15-5-11-18(22)12-6-15/h1-10,24-25H,11H2,(H,26,27)(H,28,29);2*1-12,20H,21-22H2
Pararosaniline pamoate (CI 403-A) was developed as an orally active drug for the treatment of Schistosoma japonicum infection. The clinical trial has shown that capsules were safe and effective; in addition, this drug was well tolerated with a minimum of side effects, which were mostly mild and transient and did not require interruption of treatment. Besides, pararosaniline pamoate was an inhibitor of E.histolytica Hsp90 (EhHsp90) with promising activity against the parasite Pararosaniline pamoate, that causes amebiasis worldwide. Information about the current use of this drug is not available.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| [CI-403 (PARAROSANILINE PAMOATE) IN THE TREATMENT OF SCHISTOSOMIASIS MANSONI IN BRAZIL]. | 1964 Jul |
|
| Pararosaniline pamoate (CI-403-A) in the treatment of Schistosoma japonicum infection in the Philippines. | 1967 |
|
| Heat shock protein 90 inhibitors repurposed against Entamoeba histolytica. | 2015 |
Sample Use Guides
Given orally in gelatin capsules, the drug was well tolerated even in children, with few side-effects, and was both curative and suppressive when administered in a maximum dosage of 35-40 mg/kg body-weight per day for as many as 52 days spread over a total treatment period of 203 days
Route of Administration:
Oral
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Official Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
|
NCI_THESAURUS |
C461
Created by
admin on Sat Dec 16 17:52:57 GMT 2023 , Edited by admin on Sat Dec 16 17:52:57 GMT 2023
|
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
54689796
Created by
admin on Sat Dec 16 17:52:57 GMT 2023 , Edited by admin on Sat Dec 16 17:52:57 GMT 2023
|
PRIMARY | |||
|
DTXSID50225569
Created by
admin on Sat Dec 16 17:52:57 GMT 2023 , Edited by admin on Sat Dec 16 17:52:57 GMT 2023
|
PRIMARY | |||
|
C87720
Created by
admin on Sat Dec 16 17:52:57 GMT 2023 , Edited by admin on Sat Dec 16 17:52:57 GMT 2023
|
PRIMARY | |||
|
4RJY69ERYU
Created by
admin on Sat Dec 16 17:52:57 GMT 2023 , Edited by admin on Sat Dec 16 17:52:57 GMT 2023
|
PRIMARY | |||
|
100000082792
Created by
admin on Sat Dec 16 17:52:57 GMT 2023 , Edited by admin on Sat Dec 16 17:52:57 GMT 2023
|
PRIMARY | |||
|
SUB09617MIG
Created by
admin on Sat Dec 16 17:52:57 GMT 2023 , Edited by admin on Sat Dec 16 17:52:57 GMT 2023
|
PRIMARY | |||
|
CHEMBL1368322
Created by
admin on Sat Dec 16 17:52:57 GMT 2023 , Edited by admin on Sat Dec 16 17:52:57 GMT 2023
|
PRIMARY | |||
|
1810
Created by
admin on Sat Dec 16 17:52:57 GMT 2023 , Edited by admin on Sat Dec 16 17:52:57 GMT 2023
|
PRIMARY | |||
|
7460-07-3
Created by
admin on Sat Dec 16 17:52:57 GMT 2023 , Edited by admin on Sat Dec 16 17:52:57 GMT 2023
|
PRIMARY |
PARENT (SALT/SOLVATE)
PARENT (SALT/SOLVATE)
SUBSTANCE RECORD
