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Details

Stereochemistry ACHIRAL
Molecular Formula C23H16O6.2C19H17N3
Molecular Weight 963.0863
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PARAROSANILINE PAMOATE ANHYDROUS

SMILES

NC1=CC=C(C=C1)C(C2=CC=C(N)C=C2)=C3C=CC(=N)C=C3.NC4=CC=C(C=C4)C(C5=CC=C(N)C=C5)=C6C=CC(=N)C=C6.OC(=O)C7=CC8=C(C=CC=C8)C(CC9=C%10C=CC=CC%10=CC(C(O)=O)=C9O)=C7O

InChI

InChIKey=CEYTZVVSYBTFCX-UHFFFAOYSA-N
InChI=1S/C23H16O6.2C19H17N3/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29;2*20-16-7-1-13(2-8-16)19(14-3-9-17(21)10-4-14)15-5-11-18(22)12-6-15/h1-10,24-25H,11H2,(H,26,27)(H,28,29);2*1-12,20H,21-22H2

HIDE SMILES / InChI

Molecular Formula C19H17N3
Molecular Weight 287.3584
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C23H16O6
Molecular Weight 388.3695
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Pararosaniline pamoate (CI 403-A) was developed as an orally active drug for the treatment of Schistosoma japonicum infection. The clinical trial has shown that capsules were safe and effective; in addition, this drug was well tolerated with a minimum of side effects, which were mostly mild and transient and did not require interruption of treatment. Besides, pararosaniline pamoate was an inhibitor of E.histolytica Hsp90 (EhHsp90) with promising activity against the parasite Pararosaniline pamoate, that causes amebiasis worldwide. Information about the current use of this drug is not available.

Approval Year

PubMed

PubMed

TitleDatePubMed
[CI-403 (PARAROSANILINE PAMOATE) IN THE TREATMENT OF SCHISTOSOMIASIS MANSONI IN BRAZIL].
1964 Jul
Pararosaniline pamoate (CI-403-A) in the treatment of Schistosoma japonicum infection in the Philippines.
1967
Heat shock protein 90 inhibitors repurposed against Entamoeba histolytica.
2015

Sample Use Guides

Given orally in gelatin capsules, the drug was well tolerated even in children, with few side-effects, and was both curative and suppressive when administered in a maximum dosage of 35-40 mg/kg body-weight per day for as many as 52 days spread over a total treatment period of 203 days
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Sat Dec 16 17:52:57 UTC 2023
Edited
by admin
on Sat Dec 16 17:52:57 UTC 2023
Record UNII
4RJY69ERYU
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PARAROSANILINE PAMOATE ANHYDROUS
Common Name English
.ALPHA.-(P-AMINOPHENYL)-.ALPHA.-(4-IMINO-2,5-CYCLOHEXADIEN-1-YLIDENE)-P-TOLUIDINE 4,4'-METHYLENEBIS(3-HYDROXY-2-NAPHTHOATE)
Common Name English
PARAROSANILINE EMBONATE ANHYDROUS
Common Name English
2-NAPHTHALENECARBOXYLIC ACID, 4,4'-METHYLENEBIS(3-HYDROXY-, COMPD. WITH 4-((4-AMINOPHENYL)(4-IMINO-2,5-CYCLOHEXADIEN-1-YLIDENE)METHYL)BENZENAMINE
Common Name English
PARAROSANILINE EMBONATE
INN  
INN  
Official Name English
pararosaniline embonate [INN]
Common Name English
BIS(P-ROSANILINE) PAMOATE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C461
Created by admin on Sat Dec 16 17:52:57 UTC 2023 , Edited by admin on Sat Dec 16 17:52:57 UTC 2023
Code System Code Type Description
PUBCHEM
54689796
Created by admin on Sat Dec 16 17:52:57 UTC 2023 , Edited by admin on Sat Dec 16 17:52:57 UTC 2023
PRIMARY
EPA CompTox
DTXSID50225569
Created by admin on Sat Dec 16 17:52:57 UTC 2023 , Edited by admin on Sat Dec 16 17:52:57 UTC 2023
PRIMARY
NCI_THESAURUS
C87720
Created by admin on Sat Dec 16 17:52:57 UTC 2023 , Edited by admin on Sat Dec 16 17:52:57 UTC 2023
PRIMARY
FDA UNII
4RJY69ERYU
Created by admin on Sat Dec 16 17:52:57 UTC 2023 , Edited by admin on Sat Dec 16 17:52:57 UTC 2023
PRIMARY
SMS_ID
100000082792
Created by admin on Sat Dec 16 17:52:57 UTC 2023 , Edited by admin on Sat Dec 16 17:52:57 UTC 2023
PRIMARY
EVMPD
SUB09617MIG
Created by admin on Sat Dec 16 17:52:57 UTC 2023 , Edited by admin on Sat Dec 16 17:52:57 UTC 2023
PRIMARY
ChEMBL
CHEMBL1368322
Created by admin on Sat Dec 16 17:52:57 UTC 2023 , Edited by admin on Sat Dec 16 17:52:57 UTC 2023
PRIMARY
INN
1810
Created by admin on Sat Dec 16 17:52:57 UTC 2023 , Edited by admin on Sat Dec 16 17:52:57 UTC 2023
PRIMARY
CAS
7460-07-3
Created by admin on Sat Dec 16 17:52:57 UTC 2023 , Edited by admin on Sat Dec 16 17:52:57 UTC 2023
PRIMARY
Related Record Type Details
SOLVATE->ANHYDROUS
PARENT -> SALT/SOLVATE
PARENT -> SALT/SOLVATE