BALAMAPIMOD

Details

Stereochemistry	ACHIRAL
Molecular Formula	C30H32ClN7OS
Molecular Weight	574.139
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC2=C(C=C1N3CCC(CC3)N4CCCC4)N=CC(C#N)=C2NC5=CC(Cl)=C(SC6=NC=CN6C)C=C5

InChI

InChIKey=CVAKNHIXTWLGJO-UHFFFAOYSA-N

InChI=1S/C30H32ClN7OS/c1-36-14-9-33-30(36)40-28-6-5-21(15-24(28)31)35-29-20(18-32)19-34-25-17-26(27(39-2)16-23(25)29)38-12-7-22(8-13-38)37-10-3-4-11-37/h5-6,9,14-17,19,22H,3-4,7-8,10-13H2,1-2H3,(H,34,35)

HIDE SMILES / InChI

Molecular Formula	C30H32ClN7OS
Molecular Weight	574.139
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://patents.google.com/patent/US20170020964A1 | https://adisinsight.springer.com/drugs/800026252

Balamapimod, also known as MKI 833, a mitogen-activated protein kinase (Ras/Raf/MEK) inhibitor with potential anti-tumor activity. This compound can be used for the treatment of diseases that are results of deregulation of Ras/Raf/MEK kinases.

Originator

Approval Year

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:51:58 GMT 2023` Edited by `admin` on `Sat Dec 16 17:51:58 GMT 2023`
Record UNII	7Y0IV7N95Q
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BALAMAPIMOD

Official Name

English

BALAMAPIMOD [USAN]

Common Name

English

3-QUINOLINECARBONITRILE, 4-((3-CHLORO-4-((1-METHYL-1H-IMIDAZOL-2-YL)THIO)PHENYL)AMINO)-6-METHOXY-7-(4-(1-PYRROLIDINYL)-1-PIPERIDINYL)-

Systematic Name

English

4-[[3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)sulfanyl]phenyl]amino]-6-methoxy-7-[4-(pyrrolidin-1-yl)piperidin-1-yl]quinoline-3-carbonitrile

Systematic Name

English

balamapimod [INN]

Common Name

English

MKI-833

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C2149