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Restrict the search for
m nalidixic acid
to a specific field?
Status:
Investigational
Source:
INN:imisopasem manganese [INN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Imisopasem Manganese is a manganese-based non-peptidyl mimetic of the human mitochondrial manganese superoxide dismutase (MnSOD), with potential antioxidant and radioprotective activities. Metaphore Pharmaceuticals Inc. is developing Imisopasem Manganese for the potential treatment of pain, dermatological disease and inflammation. Upon administration, imisopasem manganese mimics the activity of MnSOD and scavenges reactive oxygen species (ROS), such as superoxide anion, which prevents oxygen free radical damage to macromolecules such as DNA. This reduces ROS-mediated lipid peroxidation, prevents apoptosis and protects against oxygen free radical-induced toxicity in normal tissues.
Status:
Investigational
Source:
JAN:ACORAMIDIS HYDROCHLORIDE [JAN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Class (Stereo):
CHEMICAL (RACEMIC)
Fenamifuril is an antiinflammatory and antirheumatic agent.
Status:
Investigational
Class (Stereo):
CHEMICAL (ACHIRAL)
Girisopam (GYKI 51189), a 2,3-benzodiazepine, is a compound with anxiolytic and antipsychotic action. It has shown these effects in several animal models. Girisopam differs from the traditional 1,4-benzodiazepines because of its selective anxiolytic action without muscle relaxant and anticonvulsive activity, and because it does not have affinity for 1,4-benzodiazepine receptors. Antidepressant activity of girisopam was also reported. The binding site of girisopam in neuronal cells in the central nervous system is located exclusively to the basal ganglia. Because the danger of tolerance and dependence is lower for 2,3-benzodiazepine than 1,4-benzodiazepines, girisopam may potentially be used in treatment of addiction and affective disorders. No clinical trials were conducted in the US.
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Nifursol is an antibiotic of the nitrofuran class which inhibits the growth of the protozoa Histomonas meleagridis but is non-lethal. Although previously approved as a prophylactic feed additive for turkeys, the European Union has since banned Nifursol use in agricultural operations.
Class (Stereo):
CHEMICAL (RACEMIC)
Biclofibrate was investigated as an antilipidemic agent.
Status:
Investigational
Source:
NCT03022799: Phase 1 Interventional Completed Parkinson's Disease
(2016)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Class (Stereo):
CHEMICAL (ACHIRAL)
Clamidoxic acid is a derivative of phenoxyacetic acid developed in the late 1950s by Smith and Nephew Research Ltd. Clamidoxic acid has been shown to have anti-inflammatory activity and low toxicity in animal tests. The compound was investigated in the clinical trials in patients suffering from rheumatoid arthritis and painful uncomplicated osteoarthritis of the hip, however, no further clinical development was reported.
Class (Stereo):
CHEMICAL (EPIMERIC)
Vinpoline was studied as a central stimulant. Information about the further development of this agent is not available.
Status:
Investigational
Class (Stereo):
CHEMICAL (ACHIRAL)
Melizame is a sugar substitute for sweetening caloric or noncaloric materials.
