Ethyl orsellinate, a secondary metabolite, extracted from Himalayan lichen Parmelia reticulata Tayl, possesses antimicrobial activity and shows good inhibition of protein glycation, and urease activities. Urease produced by Helicobacter pylori is one of the major causes of the pathogenesis of peptic, and gastric ulcers, as well as related cancers. The discovery and development of new enzymes inhibitors are important for the treatment of the related diseases.