Estradiol-glucoside, also known as E2-3beta-glucoside, is a novel conjugated estrogen synthesized by attaching a glucose molecule to the 3beta position of estradiol. This glucoside derivative is a water-soluble estrogen that is easily absorbed from the gastrointestinal tract and achieves favorable systemic estrogen levels. The results of a randomized, double-blinded controlled pilot study have revealed, that estradiol-glucoside reduced serum gonadotropin levels in the premenopausal range and could be effective at reducing postmenopausal symptoms. As a conclusion, was made the assumption, that estradiol-glucoside can serve as a hormone replacement therapy.

Quinine valerate is a salt of anti-malarial alkaloid quinine. Quinine valerate is considered to exert the same anti-malarial activity as the parent compound. Quinine valerate may be mutagenic in E. coli HCR+ strains.

Valeric acid is a colorless, oily liquid with an unpleasant odor. It is highly corrosive and must be handled with care. Valeric acid is mainly used as a chemical intermediate to manufacture flavors and perfumes, synthetic lubricants, agricultural chemicals, and pharmaceuticals. It is also used as a flavoring aid in foods. Valeric acid is considered safe as a food additive by the World Health Organization.