Verrucarin A (VC-A) is a Type D macrocyclic mycotoxin which inhibits cell proliferation and induces apoptosis in cancer cells. Strong antiproliferative and apoptosis-inducing activity of verrucarin A for pancreatic ductal adenocarcinoma and prostate cancer cells through cell cycle arrest and inhibition of the prosurvival (antiapoptotic) AKT/NF-κB/mTOR signaling.has being demonstrated. Verrucarin A, a protein synthesis inhibitor, also induces growth inhibition and apoptosis in breast cancer cell lines MDA-MB-231 and T47D.