Clibucaine is a piperidine derivative possessing local anesthetic properties and used in the clinic as a local anesthetic in the 1980s.

Sinefungin, a natural nucleoside isolated from cultures of Streptomyces incarnatus and S. griseolus, is structurally related to S-adenosylhomocysteine and S-adenosylmethionine. Sinefungin is a DNA methyltransferase (DNMT) inhibitor (IC₅₀ = 0.1 - 20 uM). Sinefungin has been shown to inhibit the development of various fungi and viruses, but its major attraction to date resides in its potent antiparasitic activity. This compound has been reported to display antiparasitic activity against malarial, trypanosomal, and leishmanial species. Sinefungin inhibits pneumococcal biofilm growth in vitro and colonization in vivo, decreases AI-2 production, and downregulates luxS, pfs, and speE gene expressions. Sinefungin was significantly suppressive against both L. donovani and L. braziliensis panamensis infections in hamsters when compared with meglumine antimonate. An immunosuppressed rat model was used to investigate the anti-Cryptosporidium parvum activity of sinefungin. In infected animals, oral sinefungin therapy resulted in a dose-related suppression of oocyst shedding, which correlated with oocyst disappearance from ileal sections. When administered prior to or on the day of oocyst challenge, sinefungin successfully prevented infection. These data suggest that sinefungin could be considered as a candidate molecule in the treatment of human cryptosporidiosis, considered to be the most significant enteric opportunistic infection in AIDS.

Norvinisterone (Nor-Progestelea) is a progestin and androgen/anabolic steroid (AAS) drug. It appeared to be quite androgenic. It was used in Europe but is no longer marketed.

Domoprednate is a corticosteroid, a glucocorticoid, with anti-inflammatory and anti-allergic properties. Domoprednate is inferior to betamethasone valerate in the same category of dermatoses and equally well tolerated. It can be characterized as a medium-active corticosteroid. Domoprednate can be used topically in the treatment of skin disorders, such as eczema, psoriasis and atopic dermatitis.

Amustaline (S-303) is a quinacrine mustard compound with potential antineoplastic activity. Amustaline binds to, intercalates and crosslinks DNA and RNA. This agent is mainly used for ex vivo purposes, specifically for the inactivation of pathogens such as viruses, protozoa and bacteria in red blood cells (RBCs). When S-303 is added to red blood cells, the compound rapidly passes through membranes, including those of cells and viral envelopes, due to its amphipathic character, and intercalates into helical regions of the nucleic acids of pathogens and white blood cells. TERCEPTTMBlood System usingamustaline (S-303) and glutathione (GSH) was able to inactivate high levels of DENV and ZIKV in RBCs. S-303 system has been shown to effectively inactivate a broad spectrum of pathogens, while maintaining RBC quality.

Lucimycin (lucensomycin or etruscomycin) is a polyene antibiotic with antimycotic activity. Originally it was isolated from Streptomyces lucensis n. sp.

GALARUBICIN (DA-125) is an anthracycline derivative with anticancer activity, containing fluorine. The mechanism of action of this drug lies in inhibition of nucleic acid synthesis through intercalation with DNA. Because the structure and DNA-intercalating properties of DA-125 are similar to adriamycin, the cytotoxic effects of the two anthracyclines probably have similar biochemical mechanisms. Preclinical studies suggest that it may have greater activity and less cardiac toxicity than adriamycin. In a rodent study, administration of D-125 in higher dose levels (25 to 50 mg/kg) has been shown to result in testicular damage.

Cofisatin is a synthetic derivative of a dehydrocholic acid and isatine, invented by French Societe D'etudes et Applications Chimiques in the 1950s. The compound is claimed to promote intestinal peristaltic without causing irritation.

FLUDAZONIUM is a topical antiinfective agent.

Oxpheneridine is a mu opioid receptor agonist that possesses the spasmolytic activity and acts as a narcotic analgesic. However, this compound was not listed as an illegal drug, because of its poor solubility and low doses didn’t produce any addiction. Information about the current use of this drug is not available.