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Restrict the search for
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Spiramycin 1 Acetate is a member of the Spiramycin macrolide family of bacterio static antibiotic compounds. The family of compounds was originally isolated from cultures of Streptomyces ambofaciens, a soil bacteria native to northern France. The mixture of Spiromycines has been separated into three classes I, II, III, which each have unique structural differences. The namesake compound spiramycin (aka Spiramycin Acetate in Japan) is approved for use as an antibiotic for the treatment of Gram-positive cocci and rods, Gram-negative cocci and Legionellae, mycoplasmas, chlamydiae, spirochetes, Toxoplasma gondii and some species of Cryptosporidium.
Gardenin B is naturally occurring flavonoid isolated from Baccharis scandens, that shows potent anti-proliferative activity against human cancer cell lines. Although the exact target and binding sites of gardenin B have not yet been determined, the introduction of additional methyl groups could facilitate penetration through the cell membrane and increase the cytotoxicity in vitro. Cell cycle analysis performed in HL-60 cells showed that inhibition of cell viability by gardenin B was caused by a significant cell cycle arrest at the S and G2-M phases and accompanied by an increase in sub-G1 fraction and phosphatidylserine externalization, indicating apoptotic cell death. This methoxyflavonoid promotes the formation of apoptotic bodies and the internucleosomal degradation of DNA, resulting in the formation and eventual release of oligonucleosomal DNA fragments. Apoptosis induced by gardenin B is associated with activation of both the extrinsic and the intrinsic apoptotic pathways of cell death and occurs through a mechanism that is independent of the generation of reactive oxygen species.
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Withanoside V is a glycowithanolide of W.somnifera. Ashwagandha (Withania somnifera) contains a myriad of constituents, including withanolides named withanolide A, withanolide B, withaferin A, and withanone, along with 12-deoxy withastramonolide, withanoside V, withanoside IV. Withanoside V has shown high antioxidant potential.
