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Details

Stereochemistry ABSOLUTE
Molecular Formula C45H76N2O15
Molecular Weight 885.0893
Optical Activity UNSPECIFIED
Defined Stereocenters 19 / 19
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SPIRAMYCIN I ACETATE

SMILES

[H][C@@]1(CC[C@@H]([C@@H](C)O1)N(C)C)O[C@H]2\C=C\C=C\C[C@@H](C)OC(=O)C[C@@H](O)[C@H](OC)[C@@H](O[C@]3([H])O[C@H](C)[C@@H](O[C@@]4([H])C[C@@](C)(O)[C@@H](OC(C)=O)[C@H](C)O4)[C@@H]([C@H]3O)N(C)C)[C@@H](CC=O)C[C@H]2C

InChI

InChIKey=UYYKLUHBJONOFA-RMDIIMEUSA-N
InChI=1S/C45H76N2O15/c1-25-22-31(20-21-48)41(62-44-39(52)38(47(10)11)40(28(4)58-44)61-37-24-45(7,53)43(29(5)57-37)59-30(6)49)42(54-12)33(50)23-35(51)55-26(2)16-14-13-15-17-34(25)60-36-19-18-32(46(8)9)27(3)56-36/h13-15,17,21,25-29,31-34,36-44,50,52-53H,16,18-20,22-24H2,1-12H3/b14-13+,17-15+/t25-,26-,27-,28-,29+,31+,32+,33-,34+,36+,37+,38-,39-,40-,41+,42+,43+,44+,45-/m1/s1

HIDE SMILES / InChI
Spiramycin 1 Acetate is a member of the Spiramycin macrolide family of bacterio static antibiotic compounds. The family of compounds was originally isolated from cultures of Streptomyces ambofaciens, a soil bacteria native to northern France. The mixture of Spiromycines has been separated into three classes I, II, III, which each have unique structural differences. The namesake compound spiramycin (aka Spiramycin Acetate in Japan) is approved for use as an antibiotic for the treatment of Gram-positive cocci and rods, Gram-negative cocci and Legionellae, mycoplasmas, chlamydiae, spirochetes, Toxoplasma gondii and some species of Cryptosporidium.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
Structure activity relationships of spiramycins.
1985 Jul
Separation of spiramycin components using high-speed counter-current chromatography.
2000 Dec
Characterization of impurities in spiramycin by liquid chromatography/ion trap mass spectrometry.
2007
Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Name Type Language
SPIRAMYCIN I ACETATE
Common Name English
LEUCOMYCIN V, 9-O-(5-(DIMETHYLAMINO)TETRAHYDRO-6-METHYL-2H-PYRAN-2-YL)-, 4B-ACETATE, (9(2R,5S,6R))-
Common Name English
4''-ACETYLSPIRAMYCIN I
Common Name English
Code System Code Type Description
PUBCHEM
76956190
Created by admin on Sat Dec 16 05:52:51 GMT 2023 , Edited by admin on Sat Dec 16 05:52:51 GMT 2023
PRIMARY
CAS
130482-07-4
Created by admin on Sat Dec 16 05:52:51 GMT 2023 , Edited by admin on Sat Dec 16 05:52:51 GMT 2023
PRIMARY
FDA UNII
02245B2190
Created by admin on Sat Dec 16 05:52:51 GMT 2023 , Edited by admin on Sat Dec 16 05:52:51 GMT 2023
PRIMARY
EVMPD
SUB15354MIG
Created by admin on Sat Dec 16 05:52:51 GMT 2023 , Edited by admin on Sat Dec 16 05:52:51 GMT 2023
PRIMARY