Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C45H76N2O15 |
| Molecular Weight | 885.0893 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 19 / 19 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]1(CC[C@@H]([C@@H](C)O1)N(C)C)O[C@H]2\C=C\C=C\C[C@@H](C)OC(=O)C[C@@H](O)[C@H](OC)[C@@H](O[C@]3([H])O[C@H](C)[C@@H](O[C@@]4([H])C[C@@](C)(O)[C@@H](OC(C)=O)[C@H](C)O4)[C@@H]([C@H]3O)N(C)C)[C@@H](CC=O)C[C@H]2C
InChI
InChIKey=UYYKLUHBJONOFA-RMDIIMEUSA-N
InChI=1S/C45H76N2O15/c1-25-22-31(20-21-48)41(62-44-39(52)38(47(10)11)40(28(4)58-44)61-37-24-45(7,53)43(29(5)57-37)59-30(6)49)42(54-12)33(50)23-35(51)55-26(2)16-14-13-15-17-34(25)60-36-19-18-32(46(8)9)27(3)56-36/h13-15,17,21,25-29,31-34,36-44,50,52-53H,16,18-20,22-24H2,1-12H3/b14-13+,17-15+/t25-,26-,27-,28-,29+,31+,32+,33-,34+,36+,37+,38-,39-,40-,41+,42+,43+,44+,45-/m1/s1
| Molecular Formula | C45H76N2O15 |
| Molecular Weight | 885.0893 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 19 / 19 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Spiramycin 1 Acetate is a member of the Spiramycin macrolide family of bacterio static antibiotic compounds. The family of compounds was originally isolated from cultures of Streptomyces ambofaciens, a soil bacteria native to northern France. The mixture of Spiromycines has been separated into three classes I, II, III, which each have unique structural differences. The namesake compound spiramycin (aka Spiramycin Acetate in Japan) is approved for use as an antibiotic for the treatment of Gram-positive cocci and rods, Gram-negative cocci and Legionellae, mycoplasmas, chlamydiae, spirochetes, Toxoplasma gondii and some species of Cryptosporidium.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Structure activity relationships of spiramycins. | 1985 Jul |
|
| Chemical modification of spiramycins. VI. Synthesis and antibacterial activities of 3,3''-di-O-acyl-4''-O-sulfonyl and 3,3''-di-O-acyl-4''-O-alkyl derivatives of spiramycin I. | 1985 Oct |
|
| [Studies on acetylspiramycin. 1. Separation and chemical structures of acetylspiramycin components]. | 1990 Jun |
|
| Separation of spiramycin components using high-speed counter-current chromatography. | 2000 Dec |
|
| Characterization of impurities in spiramycin by liquid chromatography/ion trap mass spectrometry. | 2007 |
|
| [Deletion of spiramycin 3-O-acyltransferase gene from Streptomyces spiramyceticus F21 resulting in the production of spiramycin I as major component]. | 2007 Jul |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 05:52:51 GMT 2023
by
admin
on
Sat Dec 16 05:52:51 GMT 2023
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| Record UNII |
02245B2190
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| Record Status |
Validated (UNII)
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| Record Version |
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02245B2190
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SUB15354MIG
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