SPIRAMYCIN I ACETATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C45H76N2O15
Molecular Weight	885.0893
Optical Activity	UNSPECIFIED
Defined Stereocenters	19 / 19
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CO[C@H]1[C@H](O)CC(=O)O[C@H](C)C\C=C\C=C\[C@H](O[C@H]2CC[C@@H]([C@@H](C)O2)N(C)C)[C@H](C)C[C@H](CC=O)[C@@H]1O[C@@H]3O[C@H](C)[C@@H](O[C@H]4C[C@@](C)(O)[C@@H](OC(C)=O)[C@H](C)O4)[C@@H]([C@H]3O)N(C)C

InChI

InChIKey=UYYKLUHBJONOFA-RMDIIMEUSA-N

InChI=1S/C45H76N2O15/c1-25-22-31(20-21-48)41(62-44-39(52)38(47(10)11)40(28(4)58-44)61-37-24-45(7,53)43(29(5)57-37)59-30(6)49)42(54-12)33(50)23-35(51)55-26(2)16-14-13-15-17-34(25)60-36-19-18-32(46(8)9)27(3)56-36/h13-15,17,21,25-29,31-34,36-44,50,52-53H,16,18-20,22-24H2,1-12H3/b14-13+,17-15+/t25-,26-,27-,28-,29+,31+,32+,33-,34+,36+,37+,38-,39-,40-,41+,42+,43+,44+,45-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C45H76N2O15
Molecular Weight	885.0893
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	19 / 19
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/17849607 | https://www.ncbi.nlm.nih.gov/pubmed/17262895 | https://www.ncbi.nlm.nih.gov/pubmed/11153959 | https://www.ncbi.nlm.nih.gov/pubmed/2232146 | https://www.drugs.com/international/spiramycin-acetate.html | https://www.drugs.com/mmx/acetylspiramycin.html | https://www.drugbank.ca/drugs/DB06145

Spiramycin 1 Acetate is a member of the Spiramycin macrolide family of bacterio static antibiotic compounds. The family of compounds was originally isolated from cultures of Streptomyces ambofaciens, a soil bacteria native to northern France. The mixture of Spiromycines has been separated into three classes I, II, III, which each have unique structural differences. The namesake compound spiramycin (aka Spiramycin Acetate in Japan) is approved for use as an antibiotic for the treatment of Gram-positive cocci and rods, Gram-negative cocci and Legionellae, mycoplasmas, chlamydiae, spirochetes, Toxoplasma gondii and some species of Cryptosporidium.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2596

PubMed

Title	Date	PubMed
[Deletion of spiramycin 3-O-acyltransferase gene from Streptomyces spiramyceticus F21 resulting in the production of spiramycin I as major component].	2007-07	17849607
Characterization of impurities in spiramycin by liquid chromatography/ion trap mass spectrometry.	2007	17262895
Separation of spiramycin components using high-speed counter-current chromatography.	2000-12	11153959
[Studies on acetylspiramycin. 1. Separation and chemical structures of acetylspiramycin components].	1990-06	2232146
Chemical modification of spiramycins. VI. Synthesis and antibacterial activities of 3,3''-di-O-acyl-4''-O-sulfonyl and 3,3''-di-O-acyl-4''-O-alkyl derivatives of spiramycin I.	1985-10	4066488
Structure activity relationships of spiramycins.	1985-07	3902764

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:34:10 GMT 2025` Edited by `admin` on `Mon Mar 31 21:34:10 GMT 2025`
Record UNII	02245B2190
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SPIRAMYCIN I ACETATE

Common Name

English

4''-ACETYLSPIRAMYCIN I

Preferred Name

English

LEUCOMYCIN V, 9-O-(5-(DIMETHYLAMINO)TETRAHYDRO-6-METHYL-2H-PYRAN-2-YL)-, 4B-ACETATE, (9(2R,5S,6R))-

Common Name

English

Code System Code Type Description

PUBCHEM

76956190

Created by admin on Mon Mar 31 21:34:11 GMT 2025 , Edited by admin on Mon Mar 31 21:34:11 GMT 2025

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CAS

130482-07-4

Created by admin on Mon Mar 31 21:34:11 GMT 2025 , Edited by admin on Mon Mar 31 21:34:11 GMT 2025

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FDA UNII

02245B2190

Created by admin on Mon Mar 31 21:34:11 GMT 2025 , Edited by admin on Mon Mar 31 21:34:11 GMT 2025

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EVMPD

SUB15354MIG

Created by admin on Mon Mar 31 21:34:11 GMT 2025 , Edited by admin on Mon Mar 31 21:34:11 GMT 2025

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