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Restrict the search for
penicillin v
to a specific field?
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Arginyl-Glycyl-Aspartic Acid is a tripeptide composed of L-arginine, glycine, and L-aspartic acid, used as a biochemical tool in the study of cellular recognition. Arginylglycylaspartic acid hows great affinity for the integrin receptors and Arg-Gly-Asp tripeptide motif can be used for Peptide-Based Target Drug Delivery of anticancer agents. The tripeptide Arg-Gly-Asp (RGD) is an important protein sequence in the binding of proteins to cell surfaces. The RGD motif was identified in fibronectin, vitronectin, osteopontin, collagens, thrombospondin, fibrinogen, and von Willebrand factor. Many adhesive extracellular matrix, blood, and cell surface proteins recognize the RGD sequence for cell attachment.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
1,12-Dodecanediamine (Dytek-12) is a 12 carbon aliphatic diamine. It is a highly versatile polymer monomer and chemical intermediate that is useful in the manufacture of a variety of products.
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Tunicamycin V is nucleotide sugar analogs, with a modified fatty acid side-chain, produced by several Streptomyces species. In eukaryotes, Tunicamycin V inhibit transfer of N-acetylglucosamine to a lipid intermediate. A few studies suggest that tunicamycin may work as a therapeutic drug to cancer cells as it has been shown to sensitize human colon and prostate cancer cells to TRAIL-induced apoptosis.
Status:
Other
Class (Stereo):
CHEMICAL (RACEMIC)
Targets:
Conditions:
2-Carboxy-2-Phenylethyl 1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-1h-Indole-3-Acetate (Tropesin, VUFB-12018) is indometacin prodrug with potent anti-inflammatory efficacy and advantageous therapeutic properties. In experiments in vivo in rats, after oral administration of a Tropesin dose of 50 mg/kg, esterolysis was observed between 2-3, with a peak level of liberated indometacin between 10-13 h after ingestion. Tropesin was administered orally to rats and dogs in the daily therapeutic dose, triple the dose and ten times the dose for 3 months. After the highest dosage, in isolated cases, some dogs were found to have superficial erosions of the gastric mucosa and dystrophic lesions of renal tubules without biochemical correlations. Indometacin, administered in parallel doses, caused severe lesions of the gastrointestinal tract with melaena and subsequent anemia, as well as severe degenerative changes in renal tubules, in all dosage groups. From the toxicological aspect, Tropesin is substantially more acceptable than indomethacin. The anti-inflammatory and anti-arthritic activities of Tropesin in comparison with indomethacin, were studied in various models of both acute and chronic inflammatory reactions. Both compounds exhibited significant therapeutic activities without substantial quantitative differences.
