Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C38H62N4O16 |
| Molecular Weight | 830.9161 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 15 / 15 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]1(O[C@H]([C@H](O)[C@@H]1O)N2C=CC(=O)NC2=O)[C@H](O)C[C@H]3O[C@@H](O[C@@]4([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4NC(C)=O)[C@H](NC(=O)\C=C\CCCCCCCCCC(C)C)[C@@H](O)[C@H]3O
InChI
InChIKey=MEYZYGMYMLNUHJ-DIRMKAHISA-N
InChI=1S/C38H62N4O16/c1-19(2)13-11-9-7-5-4-6-8-10-12-14-24(46)40-27-31(51)28(48)22(55-37(27)58-36-26(39-20(3)44)30(50)29(49)23(18-43)56-36)17-21(45)34-32(52)33(53)35(57-34)42-16-15-25(47)41-38(42)54/h12,14-16,19,21-23,26-37,43,45,48-53H,4-11,13,17-18H2,1-3H3,(H,39,44)(H,40,46)(H,41,47,54)/b14-12+/t21-,22-,23-,26-,27-,28+,29-,30-,31-,32+,33-,34-,35-,36-,37+/m1/s1
DescriptionCurator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/6293705
Curator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/6293705
Tunicamycin V is nucleotide sugar analogs, with a modified fatty acid side-chain, produced by several Streptomyces species. In eukaryotes, Tunicamycin V inhibit transfer of N-acetylglucosamine to a lipid intermediate. A few studies suggest that tunicamycin may work as a therapeutic drug to cancer cells as it has been shown to sensitize human colon and prostate cancer cells to TRAIL-induced apoptosis.
Approval Year
Sample Use Guides
The selective cytotoxicity of tunicamycin homologues against SV40-transformed 3T3 cells (SV40-3T3) was examined. Incubation of 3T3 or virally transformed 3T3 cells with four different homologues (A1, A2, B1, and B2 at 0.1 to 0.25 microgram/ml) caused detachment and death of transformed cells after 1 to 3 days, while the nontransformed cells were almost unaffected.
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66054-36-2
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11104835
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17RV2Q5O9O
Created by
admin on Sat Dec 16 08:33:52 GMT 2023 , Edited by admin on Sat Dec 16 08:33:52 GMT 2023
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64250
Created by
admin on Sat Dec 16 08:33:52 GMT 2023 , Edited by admin on Sat Dec 16 08:33:52 GMT 2023
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ACTIVE MOIETY
