Details
Stereochemistry | ACHIRAL |
Molecular Formula | C12H28N2 |
Molecular Weight | 200.3641 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
NCCCCCCCCCCCCN
InChI
InChIKey=QFTYSVGGYOXFRQ-UHFFFAOYSA-N
InChI=1S/C12H28N2/c13-11-9-7-5-3-1-2-4-6-8-10-12-14/h1-14H2
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/26117647Curator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/26699617 | https://www.ncbi.nlm.nih.gov/pubmed/13035672 | https://www.ncbi.nlm.nih.gov/pubmed/19648006 | https://www.ncbi.nlm.nih.gov/pubmed/26117647
Sources: https://www.ncbi.nlm.nih.gov/pubmed/26117647
Curator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/26699617 | https://www.ncbi.nlm.nih.gov/pubmed/13035672 | https://www.ncbi.nlm.nih.gov/pubmed/19648006 | https://www.ncbi.nlm.nih.gov/pubmed/26117647
1,12-Dodecanediamine (Dytek-12) is a 12 carbon aliphatic diamine. It is a highly versatile polymer monomer and chemical intermediate that is useful in the manufacture of a variety of products.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2094124 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26117647 |
7.05 µM [IC50] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
PubMed
Title | Date | PubMed |
---|---|---|
Structure and optical properties of several organic-inorganic hybrids containing corner-sharing chains of bismuth iodide octahedra. | 2001 Apr 23 |
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Layer-by-layer growth of CdSe-based nanocrystal light-emitting diodes. | 2001 Mar |
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Complexation in pseudorotaxanes based on alpha-cyclodextrin and different alpha,omega-diaminoalkanes by NMR diffusion measurements. | 2002 Apr 19 |
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End-to-end correlation for a C-12 hydrocarbon chain. | 2003 Feb |
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Mechanism of charging and supercharging molecules in electrospray ionization. | 2003 Feb 26 |
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Two-component dendritic gel: effect of stereochemistry on the supramolecular chiral assembly. | 2004 Nov 19 |
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Self-assembly of two-component peptidic dendrimers: dendritic effects on gel-phase materials. | 2004 Oct 21 |
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Inhalation toxicology of fumed dodecanediamine. | 2004 Sep |
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Involvement of polyamine oxidase in abscisic acid-induced cytosolic antioxidant defense in leaves of maize. | 2009 Mar |
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In situ studies of soft- and reactive landing of mass-selected ions using infrared reflection absorption spectroscopy. | 2009 Sep 1 |
|
Polymers for colon targeted drug delivery. | 2010 Nov |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/13035672
LD50 (mouse, i.p.) = 191mg/kg
Route of Administration:
Intraperitoneal
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/19648006
The cellular viability for a macrophage cell line J774 was determined by Mosmans´s MTT microcultured tetrazolium assay. We evaluated non-infected or infected macrophages with Mycobaterium bovis Bacillus Calmette-Guerin (BCG) in the presence and absence of test compounds (1,12-Dodecanediamine). The cells were plated in flat bottom 96 well plates (2.5 10^6 cells/well/100 mkL) cultured for 24 h in a controlled atmosphere (CO2 5% at 37 C), and non-adherent cells were washed by gentle flushing with RPMI 1640 supplemented with fetal bovine serum (10%) and gentamicin (25 lg/mL). Adherent cells were infected or not with BCG (2.5 10^6 UFC/well/100 mkL) cultured in the presence of medium alone, tween 20 (3%) (live and dead controls, respectively) or different concentrations of compounds (1.0, 10.0 and 100 mkg/mL) in a triplicate assay. After 48 h, stock MTT solution (5 mg/mL of saline; 20 mL/well) was added to the culture and 4 h later, the plate was centrifugate for 2 min at 2800 rpm, supernatant was discharged and Dimethyl sulfoxide (DMSO) (100 mkL/well) was added for formazan crystals solubilization and the absorbance was read at 540 nm in a plate reader.
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SUBSTANCE RECORD