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Restrict the search for
trolamine
to a specific field?
Status:
Possibly Marketed Outside US
Source:
21 CFR 333D
(2006)
Source URL:
First approved in 2006
Source:
21 CFR 333D
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
First approved in 2002
Source:
21 CFR 333D
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Zinc Pidolate (Zinc PCA) is a topical skin product with purifying, astingent, anti-inflammatory, antiseptic activity. It has long been used as a cosmetic ingredient, because of its astringent and anti-microbial properties. Zinc Pidolate has also being shown to be effective against halitosis. Zinc PCA prevents the UV-induced MMP-1 production in vitro by suppressing the activation of AP-1. Zinc PCA was also able to enhance type I collagen synthesis in NHDFs, by increasing the expression of the mRNA encoding the ascorbic acid transporter SVCT2 in non-UV irradiated
NHDFs, which suggests its promising effect against not only photoaged skin but also for the simple atrophic change of intrinsic skin ageing. Zinc PCA is able to suppress sebum secretion by inhibiting 5-α reductase in hyperseborrhea, to suppress body odor by forming zinc salts with short-chain fatty acids, to suppress wrinkles by inhibiting AP-1 to and inhibit bacterial growth including acne related Propionibacterium acnes.
Status:
Possibly Marketed Outside US
Source:
NDA022032
(2008)
Source URL:
First approved in 1980
Source:
NADA113232
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Monoethanolamine is both a primary amine and a primary alcohol. It is an olamine derivative. Monoethanolamine occurs in every cell in the human body as the head group of Phosphatidylethanolamine. Monoethanolamine is a component of glycosylphosphatidylinositol-anchored proteins, which are essential for viability. Other sources of monoethanolamine or phosphoethanolamine in the human body are the degradation of sphingosine phosphate by sphingosine phosphate lyase and the degradation of the endocannabinoid anandamide by the fatty acid amine hydrolase. Monoethanolamine stimulates the rapid growth of mammalian cells in culture. Monoethanolamine has a cardioprotective role against ischemia/reperfusion injury via activation of the transcription factor STAT-3. Monoethanolamine is a chemical intermediate in the manufacture of cosmetics, surface-active agents, emulsifiers, pharmaceuticals, and plasticizing agents.
Status:
Other
Class:
MIXTURE
Status:
Possibly Marketed Outside US
Source:
21 CFR 333C
(2008)
Source URL:
First approved in 2008
Source:
21 CFR 333C
Source URL:
Class:
MIXTURE
Status:
Possibly Marketed Outside US
Source:
21 CFR 348
(2005)
Source URL:
First approved in 2005
Source:
21 CFR 348
Source URL:
Class:
MIXTURE
Status:
Other
Class:
POLYMER
Status:
Possibly Marketed Outside US
First approved in 2003
Source:
21 CFR 349
Source URL:
Class:
POLYMER
Polidronium Chloride is a biocide agent which can be used as a preservative, unique in its high safety profile. Polidronium Chloride is a polycationic preservative that, unlike benzalkonium chloride, does not have detergent properties. This agent complies with both the US and European Pharmacopeia guidelines for preservative efficacy. Polidronium Chloride is a large molecule that preferentially targets microorganisms and produces minimal toxicity towards mammalian cells. Polidronium Chloride compares favorably to other preservatives in terms of efficacy. Published studies demonstrate that this preservative, added to contact lens solutions, artificial tears, and ocular hypotensive drops may offer benefits in terms of ocular tolerability compared to benzalkonium chloride. Polidronium Chloride is comparable in tolerability to other alternative preservatives such as sodium perborate, Purite. Therefore, Polidronium Chloride may be considered as a viable alternative to benzalkonium chloride for many topical ophthalmic formulations.Polidronium Chloride prepared by the controlled polymerization of dimethylamine and bis-dichlorobutene, end capped with tris-beta-hydroxyethylamine.
Status:
US Approved OTC
Source:
21 CFR 358.110(b) wart remover:collodoin-like vehicle salicylic acid
Source URL:
First marketed in 1860
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Methyl salicylate (or methyl 2-hydroxybenzoate), also known as wintergreen oil, is a natural product and is present in white wine, tea, porcini mushroom Boletus edulis, Bourbon vanilla, clary sage, red sage and fruits including cherry, apple, raspberry, papaya and plum. Methyl salicylate is topically used in combination with methanol and under brand name SALONPAS to temporarily relieves mild to moderate aches and pains of muscles and joints associated with: strains, sprains, simple backache, arthritis, bruises. The precise mechanism of action of methyl salicylate is not known, but there is suggested, that it cause dilation of the capillaries thereby increasing blood flow to the area.
Status:
Investigational
Class (Stereo):
CHEMICAL (RACEMIC)
Prinomide is a carbamoylpyrrolepropionitrile derivative patented by Ciba-Geigy A.-G. as a nonsteroidal anti-inflammatory drug that has disease-modifying activity in rheumatoid arthritis. In clinical trials, Prinomide demonstrate significant improvement in symptom score and laboratory variables.
