Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C5H7NO3 |
Molecular Weight | 129.1142 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
C1CC(=N[C@]1([H])C(=O)O)O
InChI
InChIKey=ODHCTXKNWHHXJC-VKHMYHEASA-N
InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/t3-/m0/s1
Molecular Formula | C5H7NO3 |
Molecular Weight | 129.1142 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
DescriptionSources: https://www.drugs.com/otc/121041/cleansing-foaming-gel-acne-pro-skin.html | https://www.ncbi.nlm.nih.gov/pubmed/25727335 | https://www.ncbi.nlm.nih.gov/pubmed/21834944 | https://www.ulprospector.com/en/na/PersonalCare/Detail/6637/223524/EcoCare-Zinclean | http://www.scalp-health.com/zinc-pca.htmhttp://www.currentscience.ac.in/Volumes/102/02/0288.pdfCurator's Comment:: description was created based on several sources, including
http://www.cir-safety.org/sites/default/files/pca.pdf
Sources: https://www.drugs.com/otc/121041/cleansing-foaming-gel-acne-pro-skin.html | https://www.ncbi.nlm.nih.gov/pubmed/25727335 | https://www.ncbi.nlm.nih.gov/pubmed/21834944 | https://www.ulprospector.com/en/na/PersonalCare/Detail/6637/223524/EcoCare-Zinclean | http://www.scalp-health.com/zinc-pca.htmhttp://www.currentscience.ac.in/Volumes/102/02/0288.pdf
Curator's Comment:: description was created based on several sources, including
http://www.cir-safety.org/sites/default/files/pca.pdf
Pidolic acid (pyroglutamic acid) is natural amino acid derivative in which the the free amino group of glutamic acid cyclizes to form a lactam. Sodium salt of pyroglutamic acid is used in cosmetics as a moisturizer for dry skin.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL3271 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21834944 |
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Target ID: P02452|||Q15176|||Q9UML6 Gene ID: 1277.0 Gene Symbol: COL1A1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/21834944 |
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Target ID: CHEMBL2111421 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21834944 |
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Target ID: CHEMBL612639 |
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Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Preventing | CLEANSING FOAMING GEL ACNE PRO SKIN- zinc pidolate gel Approved UseLange Gel will turn into foam, during application. It will cleanse skin thoroughly without any dryness effect, in order to avoid hyperseboohea phenomenon, a main cause of acne. Launch Date1.34256958E12 |
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Primary | Unknown Approved UseUnknown |
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Primary | EcoCare™ Zinclean Approved UseUse in anti-dandruff shampoos |
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Primary | Unknown Approved UseUnknown |
PubMed
Title | Date | PubMed |
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Human seminal relaxin is a product of the same gene as human luteal relaxin. | 1992 May |
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Fast analysis of water samples for detection of anions by capillary zone electrophoresis. | 2001 |
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Chromosome 13 dementia syndromes as models of neurodegeneration. | 2001 Dec |
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Recombinant wheat antifungal PR4 proteins expressed in Escherichia coli. | 2001 Dec |
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Electrophilic fluorination of pyroglutamic acid derivatives: application of substrate-dependent reactivity and diastereoselectivity to the synthesis of optically active 4-fluoroglutamic acids. | 2001 Dec 28 |
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A simultaneous assay method for L-glutamate and L-pyroglutamate contents in soy sauce using a 5-oxoprolinase (without ATP hydrolyzing activity). | 2001 Feb |
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Inhibition of a model protease--pyroglutamate aminopeptidase by a natural oligosaccharide gum from Hakea gibbosa. | 2001 Jan 16 |
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Stability and CTL activity of N-terminal glutamic acid containing peptides. | 2001 Jun |
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Characterization of cigar tobaccos by gas chromatographic/mass spectrometric analysis of nonvolatile organic acids: application to the authentication of Cuban cigars. | 2001 Mar |
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In vivo confocal Raman microspectroscopy of the skin: noninvasive determination of molecular concentration profiles. | 2001 Mar |
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The mechanism of aubstrate eecognition of pyroglutamyl-peptidase I from Bacillus amyloliquefaciens as determined by X-ray crystallography and site-directed mutagenesis. | 2001 May 25 |
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Stability and CTL-activity of P40/ELA melanoma vaccine candidate. | 2001 Sep-Dec |
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Expression and prognostic significance of lysozyme in male breast cancer. | 2002 |
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Comparison of the positive and negative ion electrospray mass spectra of some small peptides containing pyroglutamate. | 2002 |
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Spectrophotometric assays for L-lysine alpha-oxidase and gamma-glutamylamine cyclotransferase. | 2002 Apr 15 |
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CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV. | 2002 Apr 2 |
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Conformationally restricted TRH analogues: constraining the pyroglutamate region. | 2002 Feb |
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Production of pyroglutamic acid by thermophilic lactic acid bacteria in hard-cooked mini-cheeses. | 2002 Oct |
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Refolding of amphioxus insulin-like peptide: implications of a bifurcating evolution of the different folding behavior of insulin and insulin-like growth factor 1. | 2003 Aug 19 |
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Pressure/temperature combined treatments of precursors yield hormone-like peptides with pyroglutamate at the N terminus. | 2003 Dec 31 |
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Isolation and identification of indigestible pyroglutamyl peptides in an enzymatic hydrolysate of wheat gluten prepared on an industrial scale. | 2003 Jan 1 |
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[Neuroprotective properties of pyroglutamic acid in combination with pyrrolidone]. | 2003 Jan-Feb |
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Characterization of a new bradykinin-potentiating peptide (TmF) from Trimeresurus mucrosquamatus. | 2003 Jul |
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Reinvestigation of the proposed folding and self-association of the Neuropeptide Head Activator. | 2003 Mar |
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[Oleyl pyroglutamate for use as transdermal enhancer and its enhancing mechanism]. | 2003 May |
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Proinsulin C-peptide and its C-terminal pentapeptide: degradation in human serum and Schiff base formation with subsequent CO2 incorporation. | 2003 May |
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Origin of diastereoselection in the hydrosilylation of chiral N-acyliminium intermediates derived from pyroglutamic acid. | 2004 Apr 26 |
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Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions. | 2004 Apr 9 |
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Glutamine in commercial liquid nutritional products. | 2004 Aug 11 |
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Toward the synthesis of pyroglutamate lauroyl ester: biocatalysis versus chemical catalysis. | 2004 Feb |
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Human glutaminyl cyclase and bacterial zinc aminopeptidase share a common fold and active site. | 2004 Feb 10 |
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Mass spectrometric analysis of posttranslational modifications of a carrot extracellular glycoprotein. | 2004 May 25 |
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Alpha-tocopherol pro-vitamins: synthesis, hydrolysis and accumulation in rabbit ear skin. | 2004 Oct 19 |
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The development of a higher throughput reactive intermediate screening assay incorporating micro-bore liquid chromatography-micro-electrospray ionization-tandem mass spectrometry and glutathione ethyl ester as an in vitro conjugating agent. | 2004 Sep 21 |
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Mass spectrometry analysis of recombinant human ZP3 expressed in glycosylation-deficient CHO cells. | 2004 Sep 28 |
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Emerging roles of apelin in biology and medicine. | 2005 Aug |
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Formation of extracellular glutamate from glutamine: exclusion of pyroglutamate as an intermediate. | 2005 Aug 2 |
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Nanoparticles on the basis of highly functionalized dextrans. | 2005 Aug 3 |
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Stereoselective synthesis of conformationally constrained omega-amino acid analogues from pyroglutamic acid. | 2005 Aug 7 |
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Acetaminophen-induced anion gap metabolic acidosis and 5-oxoprolinuria (pyroglutamic aciduria) acquired in hospital. | 2005 Jul |
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Identification of novel bradykinin-potentiating peptides and C-type natriuretic peptide from Lachesis muta venom. | 2005 Jul |
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Bromophenols coupled with derivatives of amino acids and nucleosides from the red alga Rhodomela confervoides. | 2005 May |
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Biomarker metabolites capturing the metabolite variance present in a rice plant developmental period. | 2005 May 31 |
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Familial Danish dementia: co-existence of Danish and Alzheimer amyloid subunits (ADan AND A{beta}) in the absence of compact plaques. | 2005 Nov 4 |
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Synthesis of 1,3-dioxo-hexahydropyrido[1,2-c][1,3]diazepine carboxylates, a new bicyclic skeleton formed by ring expansion-RCM methodology. | 2005 Sep 21 |
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Thermostability and in vitro digestibility of a purified major allergen 2S albumin (Ses i 1) from white sesame seeds (Sesamum indicum L.). | 2005 Sep 25 |
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CFSUM1 and CFSUM2 in urine from patients with chronic fatigue syndrome are methodological artefacts. | 2006 Feb |
Sample Use Guides
Lange Gel will turn into foam, during application. It will cleanse skin thoroughly without any dryness effect, in order to avoid hyperseboohea phenomenon, a main cause of acne.
Route of Administration:
Topical
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/21834944
When normal human dermal fibroblasts were irradiated with UVA
after a pre-treatment with 10 uM of Zinc Pidolate (Zinc PCA) for 16 h, this pretreatment suppressed the UVA-induced c-Fos expression to 110%,
in comparison with the value of 200% obtained without such Zinc PCA pre-treatment. Zinc PCA induced SVCT2 mRNA expression in
NHDFs in a dose-dependent manner, i.e., 115% at 25 uM and
125% at 50 uM, in comparison with the control.
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Jun 25 21:56:40 UTC 2021
by
admin
on
Fri Jun 25 21:56:40 UTC 2021
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Record UNII |
SZB83O1W42
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Record Status |
Validated (UNII)
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Record Version |
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LOINC |
75089-3
Created by
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LOINC |
13700-0
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DSLD |
2731 (Number of products:44)
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NCI_THESAURUS |
C29703
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LOINC |
29872-9
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LOINC |
29522-0
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LOINC |
53394-3
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LOINC |
53232-5
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LOINC |
43633-7
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EU-Orphan Drug |
EU/3/16/1673
Created by
admin on Fri Jun 25 21:56:40 UTC 2021 , Edited by admin on Fri Jun 25 21:56:40 UTC 2021
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Code System | Code | Type | Description | ||
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98-79-3
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1589029
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155060
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PRIMARY | RxNorm | ||
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PYROGLUTAMIC ACID
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M9383
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PRIMARY | Merck Index | ||
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4079
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98-79-3
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7405
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DB03088
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202-700-3
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SUB09825MIG
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C82933
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SZB83O1W42
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CHEMBL284718
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