U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 371 - 380 of 1728 results

Status:
Investigational
Source:
INN:uredofos
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Uredofos is a broad-spectrum anthelmintic. Uredofos is highly effective against canine tapeworms, ascarids, and hookworms when given as a single dose of 50 mg/kg and against whipworm when given at dose level of 50 mg/kg/day for 2 days. In mice complete removal of Hymenolepis nana occurred at 25 mg/kg and Syphacia obvelata was completely eliminated at all levels.
Status:
Investigational
Source:
INN:talmetoprim [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Talmetoprim was studied as an intestinal antibacterial agent. However, information about the further development of the drug is not available.
Status:
Investigational
Source:
INN:cloponone [INN]
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Cloponone is chloramphenicol derivative with antibacterial activity. It was used in combination with chloramphenicol and myralact for the treatment of trichomonal vaginitis.
Status:
Investigational
Source:
INN:chlordimorine [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Chlordimorine is Morpholinoalkyl aryl ether derivative patented by Abbott Laboratories as local anesthetic
Status:
Investigational
Source:
INN:ceftioxide
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Ceftioxide is broad-spectrum , beta-lactam antibiotic patented by German pharmaceutical company Hoechst A.-G.
Status:
Investigational
Source:
USAN:CEFUROXIME PIVOXETIL [USAN]
Source URL:

Class (Stereo):
CHEMICAL (MIXED)

Cefuroxime Pivoxetil is an ester prodrug of cefuroxime, a semisynthetic, broad-spectrum, beta-lactamase-resistant, second-generation cephalosporin with antibacterial activity. Cefuroxime binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
Status:
Investigational
Source:
INN:amitivir
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Amitivir [LY217896], an amino thiadiazole derivative, is an inhibitor of the enzyme inosine monophosphate dehydrogenase. Amitivir has activity against several influenza A and B viruses. Amitivir possesses broad antiviral activity in vitro and in animal models against or thomyxo-and paramyxoviruses. In phase I studies with healthy volunteers, single doses of up to 500 mg were well tolerated and had predictable pharmacokinetics. Oral LY217896 was in trial for prevention of experimental influenza A virus infection and illness in humans. LY217896 was associated with asymptomatic rises in serum uric acid levels and was ineffective in modifying the virologic or clinical course of experimental influenza A (H1N1) virus infection. Amitivir development was discontinued.
Status:
Investigational
Source:
INN:amidapsone
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Amidapsone (aminoureidosulfone) is an urea analog of dapsone used in treatment of herpesvirus caused Marek's diseases.
Status:
Investigational
Source:
INN:geroquinol [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Geroquinol (geranylhydroquinone) is a radioprotective agent. It is also the major contact allergen of Phacelia Crenulate (a flowering plant in the borage family), which causes skin irritation comparable in degree to the skin reaction to urushiol, the sap found in poison oak/ivy. There is no cross-reaction with poison oak or ivy.
Status:
Investigational
Source:
INN:bitipazone [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Bitipazone was developed as an antiprotozoal agent that acts upon Coccidia parasites.