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Details

Stereochemistry ACHIRAL
Molecular Formula C13H13N3O3S
Molecular Weight 291.326
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AMIDAPSONE

SMILES

NC(=O)NC1=CC=C(C=C1)S(=O)(=O)C2=CC=C(N)C=C2

InChI

InChIKey=UPWPBIUUSLIWAI-UHFFFAOYSA-N
InChI=1S/C13H13N3O3S/c14-9-1-5-11(6-2-9)20(18,19)12-7-3-10(4-8-12)16-13(15)17/h1-8H,14H2,(H3,15,16,17)

HIDE SMILES / InChI

Description

Amidapsone (aminoureidosulfone) is an urea analog of dapsone used in treatment of herpesvirus caused Marek's diseases.

Approval Year

PubMed

Sample Use Guides

In Vivo Use Guide
Chicks infected with Marek's disease (MD) virus (5000 plaque-forming units) at 1 day of age were given Amidapsone in the feed from 1 day of age until the experiment was terminated. Amidapsone, at all concentrations tested, reduced mortality due to Marek's disease. Chickens receiving Amidapsone at the 0.002% level had a 4% mortality rate, those receiving 0.005% had 9% mortality, and those receiving 0.01% had 2% mortality; mortality rates in the respective controls were 44%, 49%, and 50%.
Route of Administration: Oral