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Restrict the search for
uridine
to a specific field?
Status:
Possibly Marketed Outside US
Source:
SPIKEVAX by Catalent Indiana, LLC
(2023)
Source URL:
First approved in 2022
Source:
BLA125752
Source URL:
Class:
NUCLEIC ACID
Status:
Possibly Marketed Outside US
Source:
BLA125742
(2021)
Source URL:
First approved in 2021
Source:
BLA125742
Source URL:
Class:
NUCLEIC ACID
Status:
Possibly Marketed Outside US
Source:
BLA125742
(2021)
Source URL:
First approved in 2021
Source:
BLA125742
Source URL:
Class:
NUCLEIC ACID
Status:
Investigational
Source:
Ann Oncol. Mar 2008;19(3):520-6.: Phase 3 Human clinical trial Completed Stomach Neoplasms/mortality/surgery
Source URL:
Class:
POLYMER
Status:
Other
Class:
POLYMER
Status:
Investigational
Source:
INN:volrubigene ralaparvovec [INN]
Source URL:
Class:
STRUCTURALLY DIVERSE
Status:
Other
Class:
CONCEPT
Status:
US Approved Rx
(2015)
Source:
NDA208169
(2015)
Source URL:
First approved in 2015
Source:
NDA208169
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Uridine triacetate is used to treat an overdose of capecitabine or fluorouracil. In addition, it is used as a pyrimidine analog for uridine replacement indicated for the treatment of hereditary orotic aciduria. Following oral administration, uridine triacetate is deacetylated by nonspecific esterases present throughout the body, yielding uridine in the circulation. Uridine competitively inhibits cell damage and cell death caused by fluorouracil. Uridine can be used by essentially all cells to make uridine nucleotides, compensating for the genetic deficiency in synthesis in patients with hereditary orotic aciduria. When intracellular uridine nucleotides are restored into the normal range, overproduction of orotic acid is reduced by feedback inhibition, so that urinary excretion of orotic acid is also reduced. Adverse reactions occurring in >2% of patients receiving uridine triacetate included vomiting, nausea, and diarrhea. In vitro data showed that uridine triacetate was a weak substrate for P-glycoprotein. Due to the potential for high local (gut) concentrations of the drug after dosing, the interaction of uridine triacetate with orally administered P-gp substrate drugs cannot be ruled out.
Status:
US Approved Rx
(2018)
Source:
ANDA205067
(2018)
Source URL:
First approved in 1989
Source:
NDA019627
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Propofol (2,6-diisopropylphenol) is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. It is extensively metabolized, with most of the administered dose appearing in the urine as glucuronide conjugates. Favorable operating conditions and rapid recovery are claimed as the main advantages in using propofol, whereas disadvantages include a relatively high incidence of apnea, and blood pressure reductions. The action of propofol involves a positive modulation of the inhibitory function of the neurotransmitter gama-aminobutyric acid (GABA) through GABA-A receptors. Due to its high lipid-solubility, propofol was initially formulated as a solution with the surfactant Cremophor EL, but the occurrence of pain on injection and anaphylactoid reactions prompted to search for alternative formulations. Results from using cyclodextrins, water-soluble prodrugs, and adopting Bodor's approach to the site-specific chemical delivery system (CDS), as well as the advantages provided by computer-controlled infusion systems, are examined in some detail.
