U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Structurally Diverse
Created
by admin
on Sat Jun 26 22:54:42 UTC 2021
Edited
by admin
on Sat Jun 26 22:54:42 UTC 2021
Source Materials Class ORGANISM
Source Materials Type RECOMBINANT VIRUS
Source Materials State LIVE NON-REPLICATING GENETICALLY MODIFIED
Organism Family PARVOVIRIDAE
Organism Genus DEPENDOVIRUS
Organism Species ADENO-ASSOCIATED VIRUS
Author NONE
Infraspecific Type SUBSTRAIN
Infraspecific Name rAAV8-TBG-hUGT1A1
Part WHOLE
Record UNII
8WI5RJ8D9V
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
VOLRUBIGENE RALAPARVOVEC
INN   USAN  
Official Name English
AT003
Code English
AT-003
Code English
VOLRUBIGENE RALAPARVOVEC [INN]
Common Name English
AT-342
Code English
AT342
Code English
RECOMBINANT NON-REPLICATING ADENO-ASSOCIATED VIRAL SEROTYPE 8 (AAV8) VECTOR ENCODING THE 1A1 ISOFORM OF THE URIDINE-DIPHOSPHATE (UDP) GLUCURONOSYLTRANSFERASE (UGT1A1) GENE UNDER THE CONTROL OF A CHIMERIC THYROXINE BINDING GLOBULIN PROMOTER
Systematic Name English
VOLRUBIGENE RALAPARVOVEC [USAN]
Common Name English
Classification Tree Code System Code
EU-Orphan Drug EU/3/16/1772
Created by admin on Sat Jun 26 22:54:42 UTC 2021 , Edited by admin on Sat Jun 26 22:54:42 UTC 2021
Code System Code Type Description
INN
10921
Created by admin on Sat Jun 26 22:54:42 UTC 2021 , Edited by admin on Sat Jun 26 22:54:42 UTC 2021
PRIMARY
CAS
2092457-20-8
Created by admin on Sat Jun 26 22:54:42 UTC 2021 , Edited by admin on Sat Jun 26 22:54:42 UTC 2021
PRIMARY
FDA UNII
8WI5RJ8D9V
Created by admin on Sat Jun 26 22:54:42 UTC 2021 , Edited by admin on Sat Jun 26 22:54:42 UTC 2021
PRIMARY
NCI_THESAURUS
C171805
Created by admin on Sat Jun 26 22:54:42 UTC 2021 , Edited by admin on Sat Jun 26 22:54:42 UTC 2021
PRIMARY
Related Record Type Details
VECTOR->EXPRESSED PROTEIN
Related Record Type Details
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
VECTOR EXPRESSED PROTEIN URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A1 0RFO7VC96N
GENE_EXPRESSION VECTOR VOLRUBIGENE RALAPARVOVEC TRANSGENE INSERT 7K3J8U4MGL