Ornipressin (ornithine-8-vasopressin, POR-8), is a synthetic vasopressin analogue. Ornipressin produces vasoconstriction via vasopressin V1A receptor-mediated vascular smooth muscle cell contraction. Ornipressin is used to control bleeding in surgical practice. It was introduced in 1971, and approved for use in Germany, Switzerland, New Zealand and Australia.

Atosiban (brand name Tractocile) is a competitive antagonist of human oxytocin at receptor level. In rats and guinea pigs, atosiban was shown to bind to oxytocin receptors, to decrease the frequency of contractions and the tone of the uterine musculature, resulting in a suppression of uterine contractions. Atosiban was also shown to bind to the vasopressin receptor, thus inhibiting the effect of vasopressin. Tractocile is indicated to delay imminent pre-term birth in pregnant adult women with: − regular uterine contractions of at least 30 seconds duration at a rate of ≥ 4 per 30 minutes − a cervical dilation of 1 to 3 cm (0-3 for nulliparas) and effacement of ≥ 50% − a gestational age from 24 until 33 completed weeks − a normal foetal heart rate. Atosiban does not have U.S. Food and Drug Administration (FDA) approval for use in the United States.

Thiamine Disulfide Nitrate is a vitamin B1 derivative. It is used as a component of vitamin complexes for the treatment of neurological and other disorders

Thiamine disulfide is a vitamin B1 derivative. It is used as a component of vitamin complexes for the treatment of neurological and other disorders associated with disturbance of metabolic functions influenced by B-complex vitamins, including diabetic polyneuropathy, alcoholic peripheral neuritis and post-influenzal neuropathies, for the treatment of neuritis and neuralgia of the spinal nerves, especially facial paresis, cervical syndrome, low back pain, and ischialgia. It has being shown to be a potent inhibitor of human immunodeficiency virus (type-1) production, suggesting that thiamine disulfide may be important for AIDS chemotherapy.

Tetraarsenic Tetrasulfide (also known as Realgar, "ruby sulfur" or "ruby of arsenic") is an arsenic compound with antitumor activity, especially in acute promyelocytic leukemia that is resistant to retinoic acid. Tetraarsenic Tetrasulfide is a soft, sectile mineral occurring in monoclinic crystals, or in granular, compact, or powdery form, often in association with the related mineral, orpiment. Tetraarsenic Tetrasulfide is in wide use in traditional Chinese medicine. Early clinical exploration of Tetraarsenic Tetrasulfide for the treatment of AML and CML started in the 1960s and suggested that Tetraarsenic Tetrasulfide was a potent agent for leukemia treatment. Recently, a single-center pilot study demonstrated that Tetraarsenic Tetrasulfide treatment was effective and convenient for treating low-risk acute promyelocytic leukemia patients. Based on these clinical achievements, Tetraarsenic Tetrasulfide has been approved by the China Food and Drug Administration and recommended as a second-line chemotherapeutic agent for the treatment of acute promyelocytic leukemia in China

BISBUTYTIAMINE is a Vitamin B derivative, analgesic. BISBUTYTIAMINE has being shown to be useful for preventing and treating AIDS, because it has the effect of inhibiting the growth of HIV on early infected cells without killing the cells and both of the cytocidal and HIV-killing effects on the cells that have come to produce HIV continuously.

Carbon disulfide (CS2) in its pure form is a colourless, volatile and in-flammable liquid with a sweet aromatic odour. The technical product is a yellowish liquid with a disagreeable odour. It has been an important industrial chemical since the 1800s because of its many useful properties, including its ability to solubilise fats, rubbers, phosphorus, sulfur, and other elements. Its fat-solvent properties also make it indispensable in preparing fats, lacquers, and camphor; in refining petroleum jelly and paraffin; and in extracting oil from bones, palmstones, olives, and rags. It was also used in processing India rubber sap from tropical trees. In all these extraction processes, it has now been replaced by other solvents. Carbon disulfide's most important industrial use has been in the manufacture of regenerated cellulose rayon (by the viscose process) and cellophane. Another principal industrial use for carbon disulfide has been as a feedstock for carbon tetrachloride production. It has also been used to protect fresh fruit from insects and fungus during shipping, in adhesives for food packaging, and in the solvent extraction of growth inhibitors. Carbon disulfide has been highly suitable for other industrial applications including the vulcanisation and manufacture of rubber and rubber accessories; the production of resins, xanthates, thiocyanates, plywood adhesives, and flotation agents; solvent and spinning-solution applications, primarily in the manufacture of rayon and polymerisation inhibition of vinyl chloride; conversion and processing of hydrocarbons; petroleum-well cleaning; brightening of precious metals in electroplating; rust removal from metals; and removal and recovery of metals and other elements from waste water and other media. In agriculture, carbon disulfide has been widely used as a fumigant to control insects in stored grain, and to remove botfly larva infestations from the stomachs of horses and ectoparasites from swine. Use of carbon disulfide as a grain fumigant in the USA was voluntarily cancelled after 1985. The primary source of carbon disulfide in the environment is emission from viscose plants, around which environmental pollution is especially great. Carbon disulfide is irritating to the eyes, mucous membranes, and skin. Acute neurological effects may result from all routes of exposure and may include headache, confusion, psychosis, and coma. Acute exposure to extremely high levels of carbon disulfide may result in death. The neurotoxic effects caused by carbon disulfide may be due, in part, to its metabolic conversion to dithiocarbamates. Individuals especially susceptible to the toxic effects of carbon disulfide include those with existing disorders of the nervous system, respiratory system, cardiovascular system, or eyes.

Sulbutiamine (isobutyryl thiamine disulfide) is a lipophilic derivative of thiamine. It is available over-the-counter in several countries either as a component of nutritional supplements or as a pharmaceutical preparation. Arcalion (Sulbutiamine) is prescribed as a treatment to help patients with a range of conditions such as asthenia, chronic fatigue, diabetes, hypothyroidism, renal disease, fibromyalgia, and depression (post partum). It remedies the symptoms of weakness by increasing focus, strength (both physical and mental), and energy, making you more alert, less lethargic, and more upbeat whilst also helping to stabilize sleeping patterns. In addition, this medication can also help a patient`s memory, and strengthen thinking processes. Some patient`s have even reported slight eyesight improvements. This product is also popular with athletes as a nutritional supplement as it is a vitamin compound which will not show up in competitive sports blood testing. It can help to achieve your maximum potential and replenish energy after strenuous activities, making it possible to maintain your edge. The presence of sulbutiamine in urinary doping control samples was monitored to evaluate the relevance of its use in sports. The motivating, confidence enhancing effects of sulbutiamine are thought to be related to its ability to enhance dopamine sensitivity. In animal models sulbutiamine has been shown to increase the number of dopamine binding sites (specifically D1) in the prefrontal cortex, this effect is achieved through reduction of dopamine release. Sulbutiamine could be best thought of as a dopamine modulator rather than a compound that directly inhibits or enhances the release of dopamine. Additionally sulbutiamine has been found to enhance memory, possibly by cholinergic transmission. Research indicates that high affinity choline uptake (HACU) was moderately increased in rodent brains following sulbutiamine consumption. However it should be noted the doses used were high (300 mg/kg).

Prosultiamine (Alinamin®), a well-known thiamine derivative, was first developed by Takeda Pharmaceutical Company in Japan in the 1950s. The drug is a homolog of allithiamine produced by thiol-type vitamin B1 and allicin. Prosultiamine is converted to vitamin B1 after absorption from the gut. The drug thus enables a long-lasting high blood concentration of vitamin B1, resulting in efficient access of vitamin B1 to nervous tissue. Prosultiamine has cured many patients with vitamin B1 deficiency resulting in beriberi neuropathy and Wernicke’s encephalopathy. Prosultiamine is also a potential treatment for HTLV, since it has been shown to reduce viral load and symptoms.