Details
Stereochemistry | ACHIRAL |
Molecular Formula | C24H34N8O4S2 |
Molecular Weight | 562.708 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 2 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
C\C(N(CC1=C(N)N=C(C)N=C1)C=O)=C(/CCO)SS\C(CCO)=C(\C)N(CC2=C(N)N=C(C)N=C2)C=O
InChI
InChIKey=GFEGEDUIIYDMOX-BMJUYKDLSA-N
InChI=1S/C24H34N8O4S2/c1-15(31(13-35)11-19-9-27-17(3)29-23(19)25)21(5-7-33)37-38-22(6-8-34)16(2)32(14-36)12-20-10-28-18(4)30-24(20)26/h9-10,13-14,33-34H,5-8,11-12H2,1-4H3,(H2,25,27,29)(H2,26,28,30)/b21-15-,22-16-
Molecular Formula | C24H34N8O4S2 |
Molecular Weight | 562.708 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 2 |
Optical Activity | NONE |
DescriptionCurator's Comment: Description was created based on several sources, including http://www.mims.com/malaysia/drug/info/neurobion/?type=full
Curator's Comment: Description was created based on several sources, including http://www.mims.com/malaysia/drug/info/neurobion/?type=full
Thiamine disulfide is a vitamin B1 derivative. It is used as a component of vitamin complexes for the treatment of neurological and other disorders associated with disturbance of metabolic functions influenced by B-complex vitamins, including diabetic polyneuropathy, alcoholic peripheral neuritis and post-influenzal neuropathies, for the treatment of neuritis and neuralgia of the spinal nerves, especially facial paresis, cervical syndrome, low back pain, and ischialgia. It has being shown to be a potent inhibitor of human immunodeficiency virus (type-1) production, suggesting that thiamine disulfide may be important for AIDS chemotherapy.
CNS Activity
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4093890
Curator's Comment: shown in rats
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: WP3493 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7999140 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | Unknown Approved UseUnknown |
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Primary | Unknown Approved UseUnknown |
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Primary | Unknown Approved UseUnknown |
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Primary | Neurobion Approved UseIndications / Uses
Film-Coated Tablet: Neurological and other disorders associated with disturbance of metabolic functions influenced by B-complex vitamins, including diabetic polyneuropathy, alcoholic peripheral neuritis and post-influenzal neuropathies.
Treatment of neuritis and neuralgia of the spinal nerves, especially facial paresis, cervical syndrome, low back pain, and ischialgia.
Injection: Treatment of disorders of the peripheral nervous system: Polyneuritis, neuralgia, sciatica and shoulder-arm syndrome, lumbago-lumbalgia, intercostals neuralgia, trigeminal neuralgia, facial palsy, herpes zoster, diabetic neuropathy, optic neuritis, numbness of the extremities; as a supplement to the therapy with isoniazid, reserpine and the phenothiazines; hyperemesis gravidarum, vitamin B deficiency, cerebrovascular accidents.
Supplement therapy with isoniazid, resperpine and phenothiazines. |
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Primary | Neurobion Approved UseIndications / Uses
Film-Coated Tablet: Neurological and other disorders associated with disturbance of metabolic functions influenced by B-complex vitamins, including diabetic polyneuropathy, alcoholic peripheral neuritis and post-influenzal neuropathies.
Treatment of neuritis and neuralgia of the spinal nerves, especially facial paresis, cervical syndrome, low back pain, and ischialgia.
Injection: Treatment of disorders of the peripheral nervous system: Polyneuritis, neuralgia, sciatica and shoulder-arm syndrome, lumbago-lumbalgia, intercostals neuralgia, trigeminal neuralgia, facial palsy, herpes zoster, diabetic neuropathy, optic neuritis, numbness of the extremities; as a supplement to the therapy with isoniazid, reserpine and the phenothiazines; hyperemesis gravidarum, vitamin B deficiency, cerebrovascular accidents.
Supplement therapy with isoniazid, resperpine and phenothiazines. |
Sample Use Guides
In Vivo Use Guide
Curator's Comment: In severe cases maybe injected: 1 amp daily by deep IM (intragluteal). Milder Cases/Follow-Up Therapy: 1 amp IM 2-3 times weekly. Each 3-mL ampoule contains the following 3 essential neurotropic vitamins of the B group: Vitamin B1 (thiamine hydrochloride) 100 mg, vitamin B6 (pyridoxol hydrochloride) 100 mg, vitamin B12 5000 mcg.
1 tab of Neurobion 3 times daily to treat moderate cases
Each film-coated Neurobion tablet contains vitamins B1 (thiamine disulfide) 100 mg, vitamin B6 (pyridoxine hydrochloride) 200 mg and vitamin B12 (cyanocobalamin) 200 mcg.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7999140
Thiamine disulfide (500 uM) blocked 99.7% of HIV-1 production after 96 hr culture in acute HIV-1 (LAV-1) infection
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 01:49:07 GMT 2023
by
admin
on
Sat Dec 16 01:49:07 GMT 2023
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Record UNII |
UJV8K21YKL
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Record Status |
Validated (UNII)
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Record Version |
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1648 (Number of products:1)
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4017 (Number of products:1)
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100000088589
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SUB04797MIG
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