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Restrict the search for
icosapent ethyl
to a specific field?
Status:
Investigational
Source:
INN:naftypramide [INN]
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Naftypramide is a nonsteroidal anti-inflammatory drug. It was used in the treatment of gynecological inflammatory diseases.
Class (Stereo):
CHEMICAL (ACHIRAL)
Mitonafide is a nitro-containing antitumor drug. Mitonafide participated in clinical trials phase II in colorectal cancer patients, however, the results have shown that the drug was not active and induced severe myelotoxicity. Besides, the drug was involved in phase II for the patients with non-small cell lung cancer (NSCLC), where it was not active in spite of the safe administration. Information about the current development of this drug is not available.
Status:
Investigational
Source:
NCT02795832: Phase 1/Phase 2 Interventional Completed Atopic Dermatitis
(2016)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Investigational
Source:
INN:fenalcomine [INN]
Source URL:
Class (Stereo):
CHEMICAL (MIXED)
Fenalcomine is a coronary vasodilator, cardiotonic and local anesthetic agent. It was studied in the treatment of angina pectoris.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Gliflumide is a compound with a long-lasting hypoglycemic effect. This blood glucose lowering sulfonamide has shown a large decrease of blood glucose levels in healthy volunteers who where administered the drug orally or intravenously. A very similar reaction but delayed and prolonged response was observed for this drug compared to other insulin secretion-stimulating compounds (such as glibenclamide). High affinity of gliflumide to plasma proteins has been suggested to contribute to this delayed activity.
Status:
Investigational
Source:
INN:lersivirine [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Lersivirine (UK-453,061) is a novel second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI). It binds reverse transcriptase in a distinct way leading to a unique resistance profile. Lersivirine is a second-line NNRTI, which was investigated in a Phase IIb clinical trial. Lersivirine has shown encouraging virologic efficacy in a Phase IIa monotherapy study in NNRTI-naive patients. In a Phase IIb clinical trial in ART naive patients, clinical efficacy of lersivirine was compared with efavirenz, each administered together with tenofovir disoproxil fumarate/emtricitabine. After 48 weeks, lersivirine exhibited a slightly lower virologic response but similar immunologic efficacy. However, the trial was not powered for formal hypothesis testing of noninferiority of lersivirine. The development of lersivirine was recently stopped because the developing company determined that the compound would not provide an improvement over existing NNRTIs.
Status:
Investigational
Source:
INN:cyclexanone [INN]
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Cyclexanone is an antitussive drug developed by the Swiss pharmaceutical company Ciba. The compound is claimed to have an analgesic action and an action on central respiratory control.
Status:
Investigational
Source:
INN:dexsecoverine [INN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Dexsecoverine ia an antimuscarinic drug.
Status:
Investigational
Source:
INN:gallium (68Ga) rofapitide tetraxetan [INN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Status:
Investigational
Source:
INN:furethidine [INN]
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Furethidine, a pethidine analog was studied as an analgesic agent. This compound is not currently used in medicine and is listed in schedules of the single convention on narcotic drugs of 1961 as amended by the 1972 protocol.
